Haplotype of the Lipoprotein(a) Gene Variants rs10455872 and rs3798220 Is Associated with Parameters of Coagulation, Fibrinolysis, and Inflammation in Patients after Myocardial Infarction and Highly Elevated Lipoprotein(a) Values
Lipoprotein(a) (Lp(a)) is an independent risk factor for future coronary events. Variants rs10455872 and rs3798220 in the gene encoding Lp(a) are associated with an increased Lp(a) concentration and risk of coronary artery disease. We aimed to determine whether in high-risk coronary artery disease p...
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| author | Sabina Ugovšek Andreja Rehberger Likozar Tina Levstek Katarina Trebušak Podkrajšek Janja Zupan Miran Šebeštjen |
| author_facet | Sabina Ugovšek Andreja Rehberger Likozar Tina Levstek Katarina Trebušak Podkrajšek Janja Zupan Miran Šebeštjen |
| author_sort | Sabina Ugovšek |
| collection | DOAJ |
| description | Lipoprotein(a) (Lp(a)) is an independent risk factor for future coronary events. Variants rs10455872 and rs3798220 in the gene encoding Lp(a) are associated with an increased Lp(a) concentration and risk of coronary artery disease. We aimed to determine whether in high-risk coronary artery disease patients these two genetic variants and the kringle IV type 2 (KIV-2) repeats are associated with impairment of inflammatory and hemostatic parameters. Patients after myocardial infarction with elevated Lp(a) levels were included. Blood samples underwent biochemical and genetic analyses. In carriers of the AC haplotype, the concentrations of tumor necrosis factor (TNF)-α (4.46 vs. 3.91 ng/L, <i>p</i> = 0.046) and plasminogen activator inhibitor-1 (PAI-1) (<i>p</i> = 0.026) were significantly higher compared to non-carriers. The number of KIV-2 repeats was significantly associated with the concentration of high-sensitivity C-reactive protein (ρ = 0.251, <i>p</i> = 0.038) and overall fibrinolytic potential (r = −0.253, <i>p</i> = 0.038). In our patients, a direct association between the AC haplotype and both TNF-α and PAI-1 levels was observed. Our study shows that the number of KIV-2 repeats not only affects proatherosclerotic and proinflammatory effects of Lp(a) but is also associated with its antifibrinolytic properties. |
| first_indexed | 2024-03-08T09:54:01Z |
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| language | English |
| last_indexed | 2024-03-08T09:54:01Z |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-98f6ea37f0e94a7fba5d001feae97c1e2024-01-29T13:53:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-0125273610.3390/ijms25020736Haplotype of the Lipoprotein(a) Gene Variants rs10455872 and rs3798220 Is Associated with Parameters of Coagulation, Fibrinolysis, and Inflammation in Patients after Myocardial Infarction and Highly Elevated Lipoprotein(a) ValuesSabina Ugovšek0Andreja Rehberger Likozar1Tina Levstek2Katarina Trebušak Podkrajšek3Janja Zupan4Miran Šebeštjen5Division of Internal Medicine, University Medical Centre Ljubljana, Zaloška cesta 7, 1000 Ljubljana, SloveniaDepartment of Vascular Diseases, University Medical Centre Ljubljana, Zaloška cesta 7, 1000 Ljubljana, SloveniaLaboratory for Translational Medical Biochemistry, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, SloveniaLaboratory for Translational Medical Biochemistry, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, SloveniaFaculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, SloveniaLipoprotein(a) (Lp(a)) is an independent risk factor for future coronary events. Variants rs10455872 and rs3798220 in the gene encoding Lp(a) are associated with an increased Lp(a) concentration and risk of coronary artery disease. We aimed to determine whether in high-risk coronary artery disease patients these two genetic variants and the kringle IV type 2 (KIV-2) repeats are associated with impairment of inflammatory and hemostatic parameters. Patients after myocardial infarction with elevated Lp(a) levels were included. Blood samples underwent biochemical and genetic analyses. In carriers of the AC haplotype, the concentrations of tumor necrosis factor (TNF)-α (4.46 vs. 3.91 ng/L, <i>p</i> = 0.046) and plasminogen activator inhibitor-1 (PAI-1) (<i>p</i> = 0.026) were significantly higher compared to non-carriers. The number of KIV-2 repeats was significantly associated with the concentration of high-sensitivity C-reactive protein (ρ = 0.251, <i>p</i> = 0.038) and overall fibrinolytic potential (r = −0.253, <i>p</i> = 0.038). In our patients, a direct association between the AC haplotype and both TNF-α and PAI-1 levels was observed. Our study shows that the number of KIV-2 repeats not only affects proatherosclerotic and proinflammatory effects of Lp(a) but is also associated with its antifibrinolytic properties.https://www.mdpi.com/1422-0067/25/2/736inflammationhemostasislipoprotein(a)rs10455872rs3798220KIV-2 repeats |
| spellingShingle | Sabina Ugovšek Andreja Rehberger Likozar Tina Levstek Katarina Trebušak Podkrajšek Janja Zupan Miran Šebeštjen Haplotype of the Lipoprotein(a) Gene Variants rs10455872 and rs3798220 Is Associated with Parameters of Coagulation, Fibrinolysis, and Inflammation in Patients after Myocardial Infarction and Highly Elevated Lipoprotein(a) Values International Journal of Molecular Sciences inflammation hemostasis lipoprotein(a) rs10455872 rs3798220 KIV-2 repeats |
| title | Haplotype of the Lipoprotein(a) Gene Variants rs10455872 and rs3798220 Is Associated with Parameters of Coagulation, Fibrinolysis, and Inflammation in Patients after Myocardial Infarction and Highly Elevated Lipoprotein(a) Values |
| title_full | Haplotype of the Lipoprotein(a) Gene Variants rs10455872 and rs3798220 Is Associated with Parameters of Coagulation, Fibrinolysis, and Inflammation in Patients after Myocardial Infarction and Highly Elevated Lipoprotein(a) Values |
| title_fullStr | Haplotype of the Lipoprotein(a) Gene Variants rs10455872 and rs3798220 Is Associated with Parameters of Coagulation, Fibrinolysis, and Inflammation in Patients after Myocardial Infarction and Highly Elevated Lipoprotein(a) Values |
| title_full_unstemmed | Haplotype of the Lipoprotein(a) Gene Variants rs10455872 and rs3798220 Is Associated with Parameters of Coagulation, Fibrinolysis, and Inflammation in Patients after Myocardial Infarction and Highly Elevated Lipoprotein(a) Values |
| title_short | Haplotype of the Lipoprotein(a) Gene Variants rs10455872 and rs3798220 Is Associated with Parameters of Coagulation, Fibrinolysis, and Inflammation in Patients after Myocardial Infarction and Highly Elevated Lipoprotein(a) Values |
| title_sort | haplotype of the lipoprotein a gene variants rs10455872 and rs3798220 is associated with parameters of coagulation fibrinolysis and inflammation in patients after myocardial infarction and highly elevated lipoprotein a values |
| topic | inflammation hemostasis lipoprotein(a) rs10455872 rs3798220 KIV-2 repeats |
| url | https://www.mdpi.com/1422-0067/25/2/736 |
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