Avian Leukosis Virus Subgroup J Attenuates Type I Interferon Production Through Blocking IκB Phosphorylation

Avian Leukosis Virus Subgroup J Attenuates Type I Interferon Production Through Blocking IκB Phosphorylation

Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus that causes immunosuppression and enhances susceptibility to secondary infection, resulting in great economic losses. Although ALV-J-induced immunosuppression has been well established, the underlying molecular mechanism for such ind...

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Bibliographic Details
Main Authors: Wencheng Lin, Zhouyi Xu, Yiming Yan, Huanmin Zhang, Hongxin Li, Weiguo Chen, Feng Chen, Qingmei Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Microbiology
Subjects:
ALV-J
immunosuppression
macrophage
type I interferon
NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01089/full

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