Burden of stillbirths among women vaccinated with COVID-19 vaccines: A systematic review and meta-analysis
Objective: To estimate the global burden of stillbirths among pregnant women with the COVID-19 vaccination. Data source: In this systematic review and meta-analysis, a literature search was carried out in PubMed, Cochrane and Scopus until February 4, 2023, with language restriction (English). Study...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
|
| Series: | Travel Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1477893923000935 |
| _version_ | 1797660523214405632 |
|---|---|
| author | Shashi B. Singh Bijaya K. Padhi Aravind P. Gandhi Pallavi Lohani Nisha Kumari Geetu Singh Prakasini Satapathy Keerti Bhusan Pradhan Sarvesh Rustagi Alaa Hamza Hermis Arkadiusz Dziedzic Ranjit Sah |
| author_facet | Shashi B. Singh Bijaya K. Padhi Aravind P. Gandhi Pallavi Lohani Nisha Kumari Geetu Singh Prakasini Satapathy Keerti Bhusan Pradhan Sarvesh Rustagi Alaa Hamza Hermis Arkadiusz Dziedzic Ranjit Sah |
| author_sort | Shashi B. Singh |
| collection | DOAJ |
| description | Objective: To estimate the global burden of stillbirths among pregnant women with the COVID-19 vaccination. Data source: In this systematic review and meta-analysis, a literature search was carried out in PubMed, Cochrane and Scopus until February 4, 2023, with language restriction (English). Study selection: Title-abstract screening followed by full text review was done independently by two authors, based on the research question, “What is the prevalence of stillbirths among the pregnant women vaccinated with COVID-19 vaccines?” Data extraction: Two authors independently extracted the relevant data from every study. The third author resolved the conflicts. This study was registered in PROSPERO and followed the PRISMA guidelines. Data analysis: A Random effects model was applied to assess the pooled estimate of stillbirths. The I2 test was used to assess the heterogeneity of the articles included in the study. For checking the publication bias, the Doi plot and the contour-enhanced funnel plot were utilized. Results: The database systematic search yielded 168 articles; 11 of them were determined to be eligible for systematic review and 8 of them ended up being included for meta-analysis. The pooled prevalence of stillbirth in pregnant women vaccinated against COVID-19 infection was 0.00509 (5 per 1000 live births delivered by pregnant women vaccinated against COVID-19 (95% CI: 0.00003–0.01676). Statistically significant heterogeneity was reported across studies (I2 = 98%; p < 0.01). Conclusions: The study concluded that vaccination against COVID-19 among pregnant women had a low stillbirth rate. It adds to the existing evidence that the COVID-19 vaccine is safe and can be taken during pregnancy. |
| first_indexed | 2024-03-11T18:31:08Z |
| format | Article |
| id | doaj.art-98f815cf4dfa487ca52243af573cad97 |
| institution | Directory Open Access Journal |
| issn | 1873-0442 |
| language | English |
| last_indexed | 2024-03-11T18:31:08Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Travel Medicine and Infectious Disease |
| spelling | doaj.art-98f815cf4dfa487ca52243af573cad972023-10-13T11:03:54ZengElsevierTravel Medicine and Infectious Disease1873-04422023-09-0155102633Burden of stillbirths among women vaccinated with COVID-19 vaccines: A systematic review and meta-analysisShashi B. Singh0Bijaya K. Padhi1Aravind P. Gandhi2Pallavi Lohani3Nisha Kumari4Geetu Singh5Prakasini Satapathy6Keerti Bhusan Pradhan7Sarvesh Rustagi8Alaa Hamza Hermis9Arkadiusz Dziedzic10Ranjit Sah11Department of Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, 834009, IndiaDepartment of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India; Corresponding author.Department of Community Medicine, ESIC Medical College & Hospital, Sanathnagar, Hyderabad, 500038, IndiaDepartment of Community Medicine, Madhubani Medical College, Madhubani, 847212, IndiaRajendra Institute of Medical Sciences, Ranchi, 834009, IndiaDepartment of Community Medicine, Sarojini Naidu Medical College, Agra, 282002, India; Corresponding author.Department of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, IndiaDepartment of Healthcare Management, Chitkara University Punjab, Patiala, 140401, IndiaSchool of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, IndiaNursing Department, Al-Mustaqbal University College, 51001, Hillah, Babylon, IraqDepartment of Conservative Dentistry with Endodontics, Medical University of Silesia, Katowice, Poland; Corresponding author.Tribhuvan University Teaching Hospital, Kathmandu, 46000, Nepal; Department of Microbiology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India; Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, 442001, India; Corresponding author. Tribhuvan University Teaching Hospital, Kathmandu, 46000, Nepal.Objective: To estimate the global burden of stillbirths among pregnant women with the COVID-19 vaccination. Data source: In this systematic review and meta-analysis, a literature search was carried out in PubMed, Cochrane and Scopus until February 4, 2023, with language restriction (English). Study selection: Title-abstract screening followed by full text review was done independently by two authors, based on the research question, “What is the prevalence of stillbirths among the pregnant women vaccinated with COVID-19 vaccines?” Data extraction: Two authors independently extracted the relevant data from every study. The third author resolved the conflicts. This study was registered in PROSPERO and followed the PRISMA guidelines. Data analysis: A Random effects model was applied to assess the pooled estimate of stillbirths. The I2 test was used to assess the heterogeneity of the articles included in the study. For checking the publication bias, the Doi plot and the contour-enhanced funnel plot were utilized. Results: The database systematic search yielded 168 articles; 11 of them were determined to be eligible for systematic review and 8 of them ended up being included for meta-analysis. The pooled prevalence of stillbirth in pregnant women vaccinated against COVID-19 infection was 0.00509 (5 per 1000 live births delivered by pregnant women vaccinated against COVID-19 (95% CI: 0.00003–0.01676). Statistically significant heterogeneity was reported across studies (I2 = 98%; p < 0.01). Conclusions: The study concluded that vaccination against COVID-19 among pregnant women had a low stillbirth rate. It adds to the existing evidence that the COVID-19 vaccine is safe and can be taken during pregnancy.http://www.sciencedirect.com/science/article/pii/S1477893923000935COVID-19 vaccineStillbirthPregnancyComplications |
| spellingShingle | Shashi B. Singh Bijaya K. Padhi Aravind P. Gandhi Pallavi Lohani Nisha Kumari Geetu Singh Prakasini Satapathy Keerti Bhusan Pradhan Sarvesh Rustagi Alaa Hamza Hermis Arkadiusz Dziedzic Ranjit Sah Burden of stillbirths among women vaccinated with COVID-19 vaccines: A systematic review and meta-analysis Travel Medicine and Infectious Disease COVID-19 vaccine Stillbirth Pregnancy Complications |
| title | Burden of stillbirths among women vaccinated with COVID-19 vaccines: A systematic review and meta-analysis |
| title_full | Burden of stillbirths among women vaccinated with COVID-19 vaccines: A systematic review and meta-analysis |
| title_fullStr | Burden of stillbirths among women vaccinated with COVID-19 vaccines: A systematic review and meta-analysis |
| title_full_unstemmed | Burden of stillbirths among women vaccinated with COVID-19 vaccines: A systematic review and meta-analysis |
| title_short | Burden of stillbirths among women vaccinated with COVID-19 vaccines: A systematic review and meta-analysis |
| title_sort | burden of stillbirths among women vaccinated with covid 19 vaccines a systematic review and meta analysis |
| topic | COVID-19 vaccine Stillbirth Pregnancy Complications |
| url | http://www.sciencedirect.com/science/article/pii/S1477893923000935 |
| work_keys_str_mv | AT shashibsingh burdenofstillbirthsamongwomenvaccinatedwithcovid19vaccinesasystematicreviewandmetaanalysis AT bijayakpadhi burdenofstillbirthsamongwomenvaccinatedwithcovid19vaccinesasystematicreviewandmetaanalysis AT aravindpgandhi burdenofstillbirthsamongwomenvaccinatedwithcovid19vaccinesasystematicreviewandmetaanalysis AT pallavilohani burdenofstillbirthsamongwomenvaccinatedwithcovid19vaccinesasystematicreviewandmetaanalysis AT nishakumari burdenofstillbirthsamongwomenvaccinatedwithcovid19vaccinesasystematicreviewandmetaanalysis AT geetusingh burdenofstillbirthsamongwomenvaccinatedwithcovid19vaccinesasystematicreviewandmetaanalysis AT prakasinisatapathy burdenofstillbirthsamongwomenvaccinatedwithcovid19vaccinesasystematicreviewandmetaanalysis AT keertibhusanpradhan burdenofstillbirthsamongwomenvaccinatedwithcovid19vaccinesasystematicreviewandmetaanalysis AT sarveshrustagi burdenofstillbirthsamongwomenvaccinatedwithcovid19vaccinesasystematicreviewandmetaanalysis AT alaahamzahermis burdenofstillbirthsamongwomenvaccinatedwithcovid19vaccinesasystematicreviewandmetaanalysis AT arkadiuszdziedzic burdenofstillbirthsamongwomenvaccinatedwithcovid19vaccinesasystematicreviewandmetaanalysis AT ranjitsah burdenofstillbirthsamongwomenvaccinatedwithcovid19vaccinesasystematicreviewandmetaanalysis |