Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer

Extrahepatic bile duct carcinoma is a potentially malignant gastrointestinal lesion. Cancer cells spread via the lymphatic system to regional lymph nodes and help in tumor progression. However, there are no reports on the prognostic impact of extracapsular lymph node invasion and myofibroblastic act...

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Main Authors: Tadashi Yoshizawa, Keinosuke Ishido, Kensuke Saito, Toshihiro Haga, Hiroko Seino, Yunyan Wu, Satoko Morohashi, Kenichi Hakamada, Hiroshi Kijima
Format: Article
Language:English
Published: SAGE Publishing 2017-09-01
Series:Clinical Medicine Insights: Pathology
Online Access:https://doi.org/10.1177/1179555717729652
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author Tadashi Yoshizawa
Keinosuke Ishido
Kensuke Saito
Toshihiro Haga
Hiroko Seino
Yunyan Wu
Satoko Morohashi
Kenichi Hakamada
Hiroshi Kijima
author_facet Tadashi Yoshizawa
Keinosuke Ishido
Kensuke Saito
Toshihiro Haga
Hiroko Seino
Yunyan Wu
Satoko Morohashi
Kenichi Hakamada
Hiroshi Kijima
author_sort Tadashi Yoshizawa
collection DOAJ
description Extrahepatic bile duct carcinoma is a potentially malignant gastrointestinal lesion. Cancer cells spread via the lymphatic system to regional lymph nodes and help in tumor progression. However, there are no reports on the prognostic impact of extracapsular lymph node invasion and myofibroblastic activity in this cancer. Hence, we classified the histopathologic patterns of lymph nodes into 2 patterns: extracapsular lymph node invasion or not. Based on this, we investigated 32 cases of extrahepatic bile duct cancer with lymph node metastasis and classified 21 cases as positive and 11 cases as negative. The extracapsular lymph node invasion cases were associated with poor disease-free survival and overall survival. The myofibroblast density of the metastatic foci was significantly higher in the extracapsular lymph node invasion cases. This is the first study to demonstrate that extracapsular lymph node invasion cases were associated with poor prognosis and that the myofibroblast distribution contributed to malignancy.
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spelling doaj.art-98f8d7c1c95e4b8ebff2a257de071fd02022-12-22T01:18:09ZengSAGE PublishingClinical Medicine Insights: Pathology1179-55572017-09-011010.1177/1179555717729652Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct CancerTadashi Yoshizawa0Keinosuke Ishido1Kensuke Saito2Toshihiro Haga3Hiroko Seino4Yunyan Wu5Satoko Morohashi6Kenichi Hakamada7Hiroshi Kijima8Department of Pathology and Bioscience, Graduate School of Medicine, Hirosaki University, Hirosaki, JapanDepartment of Gastroenterological Surgery, Graduate School of Medicine, Hirosaki University, Hirosaki, JapanDepartment of Pathology and Bioscience, Graduate School of Medicine, Hirosaki University, Hirosaki, JapanDepartment of Pathology and Bioscience, Graduate School of Medicine, Hirosaki University, Hirosaki, JapanDepartment of Pathology and Bioscience, Graduate School of Medicine, Hirosaki University, Hirosaki, JapanDepartment of Pathology and Bioscience, Graduate School of Medicine, Hirosaki University, Hirosaki, JapanDepartment of Pathology and Bioscience, Graduate School of Medicine, Hirosaki University, Hirosaki, JapanDepartment of Gastroenterological Surgery, Graduate School of Medicine, Hirosaki University, Hirosaki, JapanDepartment of Pathology and Bioscience, Graduate School of Medicine, Hirosaki University, Hirosaki, JapanExtrahepatic bile duct carcinoma is a potentially malignant gastrointestinal lesion. Cancer cells spread via the lymphatic system to regional lymph nodes and help in tumor progression. However, there are no reports on the prognostic impact of extracapsular lymph node invasion and myofibroblastic activity in this cancer. Hence, we classified the histopathologic patterns of lymph nodes into 2 patterns: extracapsular lymph node invasion or not. Based on this, we investigated 32 cases of extrahepatic bile duct cancer with lymph node metastasis and classified 21 cases as positive and 11 cases as negative. The extracapsular lymph node invasion cases were associated with poor disease-free survival and overall survival. The myofibroblast density of the metastatic foci was significantly higher in the extracapsular lymph node invasion cases. This is the first study to demonstrate that extracapsular lymph node invasion cases were associated with poor prognosis and that the myofibroblast distribution contributed to malignancy.https://doi.org/10.1177/1179555717729652
spellingShingle Tadashi Yoshizawa
Keinosuke Ishido
Kensuke Saito
Toshihiro Haga
Hiroko Seino
Yunyan Wu
Satoko Morohashi
Kenichi Hakamada
Hiroshi Kijima
Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer
Clinical Medicine Insights: Pathology
title Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer
title_full Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer
title_fullStr Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer
title_full_unstemmed Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer
title_short Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer
title_sort prognostic impact of extracapsular lymph node invasion and myofibroblastic activity in extrahepatic bile duct cancer
url https://doi.org/10.1177/1179555717729652
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