Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge
Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at support...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396421000840 |
| _version_ | 1818596549447385088 |
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| author | Martin S. Winkler Tomasz Skirecki Frank M. Brunkhorst Sara Cajander Jean-Marc Cavaillon Ricard Ferrer Stefanie B. Flohé Alberto García-Salido Evangelos J. Giamarellos-Bourboulis Massimo Girardis Matthijs Kox Gunnar Lachmann Ignacio Martin-Loeches Mihai G. Netea Thibaud Spinetti Joerg C. Schefold Antoni Torres Florian Uhle Fabienne Venet Sebastian Weis André Scherag Ignacio Rubio Marcin F. Osuchowski |
| author_facet | Martin S. Winkler Tomasz Skirecki Frank M. Brunkhorst Sara Cajander Jean-Marc Cavaillon Ricard Ferrer Stefanie B. Flohé Alberto García-Salido Evangelos J. Giamarellos-Bourboulis Massimo Girardis Matthijs Kox Gunnar Lachmann Ignacio Martin-Loeches Mihai G. Netea Thibaud Spinetti Joerg C. Schefold Antoni Torres Florian Uhle Fabienne Venet Sebastian Weis André Scherag Ignacio Rubio Marcin F. Osuchowski |
| author_sort | Martin S. Winkler |
| collection | DOAJ |
| description | Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at supporting clinical evidence rapidly emerge. In this review, we characterize the existing animal models exposing their relevance and limitations as well as outline their utility in COVID-19 drug and vaccine development. Concurrently, we summarize the status of clinical trial research and discuss the novel tactics utilized in the largest multi-center trials aiming to accelerate generation of reliable results that may subsequently shape COVID-19 clinical treatment practices. We also highlight areas of improvement for animal studies in order to elevate their translational utility. In pandemics, to optimize the use of strained resources in a short time-frame, optimizing and strengthening the synergy between the preclinical and clinical domains is pivotal. |
| first_indexed | 2024-12-16T11:33:41Z |
| format | Article |
| id | doaj.art-98f8d9930d774bf882699ae84368420a |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-16T11:33:41Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-98f8d9930d774bf882699ae84368420a2022-12-21T22:33:10ZengElsevierEBioMedicine2352-39642021-04-0166103291Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challengeMartin S. Winkler0Tomasz Skirecki1Frank M. Brunkhorst2Sara Cajander3Jean-Marc Cavaillon4Ricard Ferrer5Stefanie B. Flohé6Alberto García-Salido7Evangelos J. Giamarellos-Bourboulis8Massimo Girardis9Matthijs Kox10Gunnar Lachmann11Ignacio Martin-Loeches12Mihai G. Netea13Thibaud Spinetti14Joerg C. Schefold15Antoni Torres16Florian Uhle17Fabienne Venet18Sebastian Weis19André Scherag20Ignacio Rubio21Marcin F. Osuchowski22Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Robert-Koch-Str. 40, 37085 Göttingen, GermanyLaboratory of Flow Cytometry, Centre of Postgraduate Medical Education, Warsaw, PolandDept. of Anesthesiology and Intensive Care Medicine & Center for Sepsis Control and Care (CSCC), Jena University Hospital-Friedrich Schiller University, Am Klinikum 1, 07747 Jena, Germany; Center for Clinical Studies, Jena University Hospital, 07747 Jena, GermanyDepartment of Infectious Diseases, Faculty of Medicine and Health, Örebro University, SwedenFrench National Research Agency (ANR), Paris, FranceIntensive Care Department and Shock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, Barcelona, 08035, Spain; Centro de Investigación Biomedica En Red-Enfermedades Respiratorias (CibeRes, CB06/06/0028), Instituto de salud Carlos III (ISCIII), Av. de Monforte de Lemos, 5, 28029 Madrid, SpainDepartment of Trauma, Hand, and Reconstructive Surgery, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, GermanyPediatric Critical Care Unit, Hospital Infantil Universitario Niño Jesús, Madrid, Spain4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens 12462, GreeceDepartment of Anesthesia and Intensive Care, University Hospital of Modena, ItalyDepartment of Intensive Care Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The NetherlandsDepartment of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité – Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; Berlin Institute of Health (BIH), Anna-Louisa-Karsch-Straße 2, 10178 Berlin, GermanyMultidisciplinary Intensive Care Research Organization (MICRO), St. James's Hospital, James's St N, Ushers, Dublin, D03 VX82, IrelandDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, 3010 Bern, SwitzerlandDepartment of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, 3010 Bern, SwitzerlandPneumology Department, Respiratory Institute (ICR), Hospital Clinic of Barcelona - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) - University of Barcelona (UB), SpainDepartment of Anesthesiology, Heidelberg University Hospital, Im Neuenheimer Feld 110, 69120 Heidelberg, GermanyHospices Civils de Lyon, Immunology Laboratory, Edouard Herriot Hospital, 5 Place d'Arsonval, 69003 Lyon, France; EA 7426 ''Pathophysiology of Injury-Induced Immunosuppression - PI3'', Université Claude Bernard Lyon 1/bioMérieux/Hospices Civils de Lyon, Edouard Herriot Hospital, 5 Place d'Arsonval, 69003 Lyon, FranceDept. of Anesthesiology and Intensive Care Medicine & Center for Sepsis Control and Care (CSCC), Jena University Hospital-Friedrich Schiller University, Am Klinikum 1, 07747 Jena, Germany; Institute for Infectious Disease and Infection Control, Jena University Hospital-Friedrich Schiller University, Am Klinikum 1, 07747 Jena, GermanyInstitute of Medical Statistics, Computer and Data Sciences, Jena University Hospital-Friedrich Schiller University, Bachstrasse 18, 07743 Jena, GermanyDept. of Anesthesiology and Intensive Care Medicine & Center for Sepsis Control and Care (CSCC), Jena University Hospital-Friedrich Schiller University, Am Klinikum 1, 07747 Jena, GermanyLudwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Donaueschingenstrasse 13, 1200, Vienna, Austria; Corresponding author.Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at supporting clinical evidence rapidly emerge. In this review, we characterize the existing animal models exposing their relevance and limitations as well as outline their utility in COVID-19 drug and vaccine development. Concurrently, we summarize the status of clinical trial research and discuss the novel tactics utilized in the largest multi-center trials aiming to accelerate generation of reliable results that may subsequently shape COVID-19 clinical treatment practices. We also highlight areas of improvement for animal studies in order to elevate their translational utility. In pandemics, to optimize the use of strained resources in a short time-frame, optimizing and strengthening the synergy between the preclinical and clinical domains is pivotal.http://www.sciencedirect.com/science/article/pii/S2352396421000840COVID-19Animal modelPre-clinical researchPandemicClinical trialVaccine |
| spellingShingle | Martin S. Winkler Tomasz Skirecki Frank M. Brunkhorst Sara Cajander Jean-Marc Cavaillon Ricard Ferrer Stefanie B. Flohé Alberto García-Salido Evangelos J. Giamarellos-Bourboulis Massimo Girardis Matthijs Kox Gunnar Lachmann Ignacio Martin-Loeches Mihai G. Netea Thibaud Spinetti Joerg C. Schefold Antoni Torres Florian Uhle Fabienne Venet Sebastian Weis André Scherag Ignacio Rubio Marcin F. Osuchowski Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge EBioMedicine COVID-19 Animal model Pre-clinical research Pandemic Clinical trial Vaccine |
| title | Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge |
| title_full | Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge |
| title_fullStr | Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge |
| title_full_unstemmed | Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge |
| title_short | Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge |
| title_sort | bridging animal and clinical research during sars cov 2 pandemic a new old challenge |
| topic | COVID-19 Animal model Pre-clinical research Pandemic Clinical trial Vaccine |
| url | http://www.sciencedirect.com/science/article/pii/S2352396421000840 |
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