Bone regeneration: current concepts and future directions
<p>Abstract</p> <p>Bone regeneration is a complex, well-orchestrated physiological process of bone formation, which can be seen during normal fracture healing, and is involved in continuous remodelling throughout adult life. However, there are complex clinical conditions in which b...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-05-01
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| Series: | BMC Medicine |
| Online Access: | http://www.biomedcentral.com/1741-7015/9/66 |
| _version_ | 1818825066746478592 |
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| author | McGonagle Dennis Jones Elena Dimitriou Rozalia Giannoudis Peter V |
| author_facet | McGonagle Dennis Jones Elena Dimitriou Rozalia Giannoudis Peter V |
| author_sort | McGonagle Dennis |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Bone regeneration is a complex, well-orchestrated physiological process of bone formation, which can be seen during normal fracture healing, and is involved in continuous remodelling throughout adult life. However, there are complex clinical conditions in which bone regeneration is required in large quantity, such as for skeletal reconstruction of large bone defects created by trauma, infection, tumour resection and skeletal abnormalities, or cases in which the regenerative process is compromised, including avascular necrosis, atrophic non-unions and osteoporosis. Currently, there is a plethora of different strategies to augment the impaired or 'insufficient' bone-regeneration process, including the 'gold standard' autologous bone graft, free fibula vascularised graft, allograft implantation, and use of growth factors, osteoconductive scaffolds, osteoprogenitor cells and distraction osteogenesis. Improved 'local' strategies in terms of tissue engineering and gene therapy, or even 'systemic' enhancement of bone repair, are under intense investigation, in an effort to overcome the limitations of the current methods, to produce bone-graft substitutes with biomechanical properties that are as identical to normal bone as possible, to accelerate the overall regeneration process, or even to address systemic conditions, such as skeletal disorders and osteoporosis.</p> |
| first_indexed | 2024-12-19T00:05:52Z |
| format | Article |
| id | doaj.art-98fa3c3a8f794e6d8759b00d3cdd3ae8 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-12-19T00:05:52Z |
| publishDate | 2011-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-98fa3c3a8f794e6d8759b00d3cdd3ae82022-12-21T20:46:13ZengBMCBMC Medicine1741-70152011-05-01916610.1186/1741-7015-9-66Bone regeneration: current concepts and future directionsMcGonagle DennisJones ElenaDimitriou RozaliaGiannoudis Peter V<p>Abstract</p> <p>Bone regeneration is a complex, well-orchestrated physiological process of bone formation, which can be seen during normal fracture healing, and is involved in continuous remodelling throughout adult life. However, there are complex clinical conditions in which bone regeneration is required in large quantity, such as for skeletal reconstruction of large bone defects created by trauma, infection, tumour resection and skeletal abnormalities, or cases in which the regenerative process is compromised, including avascular necrosis, atrophic non-unions and osteoporosis. Currently, there is a plethora of different strategies to augment the impaired or 'insufficient' bone-regeneration process, including the 'gold standard' autologous bone graft, free fibula vascularised graft, allograft implantation, and use of growth factors, osteoconductive scaffolds, osteoprogenitor cells and distraction osteogenesis. Improved 'local' strategies in terms of tissue engineering and gene therapy, or even 'systemic' enhancement of bone repair, are under intense investigation, in an effort to overcome the limitations of the current methods, to produce bone-graft substitutes with biomechanical properties that are as identical to normal bone as possible, to accelerate the overall regeneration process, or even to address systemic conditions, such as skeletal disorders and osteoporosis.</p>http://www.biomedcentral.com/1741-7015/9/66 |
| spellingShingle | McGonagle Dennis Jones Elena Dimitriou Rozalia Giannoudis Peter V Bone regeneration: current concepts and future directions BMC Medicine |
| title | Bone regeneration: current concepts and future directions |
| title_full | Bone regeneration: current concepts and future directions |
| title_fullStr | Bone regeneration: current concepts and future directions |
| title_full_unstemmed | Bone regeneration: current concepts and future directions |
| title_short | Bone regeneration: current concepts and future directions |
| title_sort | bone regeneration current concepts and future directions |
| url | http://www.biomedcentral.com/1741-7015/9/66 |
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