MicroRNA-223 Regulates the Development of Cardiovascular Lesions in LCWE-Induced Murine Kawasaki Disease Vasculitis by Repressing the NLRP3 Inflammasome

MicroRNA-223 Regulates the Development of Cardiovascular Lesions in LCWE-Induced Murine Kawasaki Disease Vasculitis by Repressing the NLRP3 Inflammasome

Kawasaki disease (KD), an acute febrile childhood illness and systemic vasculitis of unknown etiology, is the leading cause of acquired heart disease among children. Experimental data from murine models of KD vasculitis and transcriptomics data generated from whole blood of KD patients indicate the...

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Bibliographic Details
Main Authors: Daisuke Maruyama, Begüm Kocatürk, Youngho Lee, Masanori Abe, Malcolm Lane, Debbie Moreira, Shuang Chen, Michael C. Fishbein, Rebecca A. Porritt, Magali Noval Rivas, Moshe Arditi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pediatrics
Subjects:
miR-223
IL-1 beta
Kawasaki disease
vasculitis
NLRP3
LCWE
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.662953/full

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