Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial
Abstract Post-COVID-19 condition refers to a range of persisting physical, neurocognitive, and neuropsychological symptoms after SARS-CoV-2 infection. The mechanism can be related to brain tissue pathology caused by virus invasion or indirectly by neuroinflammation and hypercoagulability. This rando...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15565-0 |
| _version_ | 1811293712208101376 |
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| author | Shani Zilberman-Itskovich Merav Catalogna Efrat Sasson Karin Elman-Shina Amir Hadanny Erez Lang Shachar Finci Nir Polak Gregory Fishlev Calanit Korin Ran Shorer Yoav Parag Marina Sova Shai Efrati |
| author_facet | Shani Zilberman-Itskovich Merav Catalogna Efrat Sasson Karin Elman-Shina Amir Hadanny Erez Lang Shachar Finci Nir Polak Gregory Fishlev Calanit Korin Ran Shorer Yoav Parag Marina Sova Shai Efrati |
| author_sort | Shani Zilberman-Itskovich |
| collection | DOAJ |
| description | Abstract Post-COVID-19 condition refers to a range of persisting physical, neurocognitive, and neuropsychological symptoms after SARS-CoV-2 infection. The mechanism can be related to brain tissue pathology caused by virus invasion or indirectly by neuroinflammation and hypercoagulability. This randomized, sham-control, double blind trial evaluated the effect of hyperbaric oxygen therapy (HBOT or HBO2 therapy) on post-COVID-19 patients with ongoing symptoms for at least 3 months after confirmed infection. Seventy-three patients were randomized to receive daily 40 session of HBOT (n = 37) or sham (n = 36). Follow-up assessments were performed at baseline and 1–3 weeks after the last treatment session. Following HBOT, there was a significant group-by-time interaction in global cognitive function, attention and executive function (d = 0.495, p = 0.038; d = 0.477, p = 0.04 and d = 0.463, p = 0.05 respectively). Significant improvement was also demonstrated in the energy domain (d = 0.522, p = 0.029), sleep (d = − 0.48, p = 0.042), psychiatric symptoms (d = 0.636, p = 0.008), and pain interference (d = 0.737, p = 0.001). Clinical outcomes were associated with significant improvement in brain MRI perfusion and microstructural changes in the supramarginal gyrus, left supplementary motor area, right insula, left frontal precentral gyrus, right middle frontal gyrus, and superior corona radiate. These results indicate that HBOT can induce neuroplasticity and improve cognitive, psychiatric, fatigue, sleep and pain symptoms of patients suffering from post-COVID-19 condition. HBOT’s beneficial effect may be attributed to increased brain perfusion and neuroplasticity in regions associated with cognitive and emotional roles. |
| first_indexed | 2024-04-13T05:05:39Z |
| format | Article |
| id | doaj.art-98fc34f9e54c4c979a1ca60e3eecd68d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T05:05:39Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-98fc34f9e54c4c979a1ca60e3eecd68d2022-12-22T03:01:11ZengNature PortfolioScientific Reports2045-23222022-07-0112111010.1038/s41598-022-15565-0Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trialShani Zilberman-Itskovich0Merav Catalogna1Efrat Sasson2Karin Elman-Shina3Amir Hadanny4Erez Lang5Shachar Finci6Nir Polak7Gregory Fishlev8Calanit Korin9Ran Shorer10Yoav Parag11Marina Sova12Shai Efrati13Sagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterSagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical CenterAbstract Post-COVID-19 condition refers to a range of persisting physical, neurocognitive, and neuropsychological symptoms after SARS-CoV-2 infection. The mechanism can be related to brain tissue pathology caused by virus invasion or indirectly by neuroinflammation and hypercoagulability. This randomized, sham-control, double blind trial evaluated the effect of hyperbaric oxygen therapy (HBOT or HBO2 therapy) on post-COVID-19 patients with ongoing symptoms for at least 3 months after confirmed infection. Seventy-three patients were randomized to receive daily 40 session of HBOT (n = 37) or sham (n = 36). Follow-up assessments were performed at baseline and 1–3 weeks after the last treatment session. Following HBOT, there was a significant group-by-time interaction in global cognitive function, attention and executive function (d = 0.495, p = 0.038; d = 0.477, p = 0.04 and d = 0.463, p = 0.05 respectively). Significant improvement was also demonstrated in the energy domain (d = 0.522, p = 0.029), sleep (d = − 0.48, p = 0.042), psychiatric symptoms (d = 0.636, p = 0.008), and pain interference (d = 0.737, p = 0.001). Clinical outcomes were associated with significant improvement in brain MRI perfusion and microstructural changes in the supramarginal gyrus, left supplementary motor area, right insula, left frontal precentral gyrus, right middle frontal gyrus, and superior corona radiate. These results indicate that HBOT can induce neuroplasticity and improve cognitive, psychiatric, fatigue, sleep and pain symptoms of patients suffering from post-COVID-19 condition. HBOT’s beneficial effect may be attributed to increased brain perfusion and neuroplasticity in regions associated with cognitive and emotional roles.https://doi.org/10.1038/s41598-022-15565-0 |
| spellingShingle | Shani Zilberman-Itskovich Merav Catalogna Efrat Sasson Karin Elman-Shina Amir Hadanny Erez Lang Shachar Finci Nir Polak Gregory Fishlev Calanit Korin Ran Shorer Yoav Parag Marina Sova Shai Efrati Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial Scientific Reports |
| title | Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial |
| title_full | Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial |
| title_fullStr | Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial |
| title_full_unstemmed | Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial |
| title_short | Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial |
| title_sort | hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post covid condition randomized controlled trial |
| url | https://doi.org/10.1038/s41598-022-15565-0 |
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