Effect of Solubilizers on the Androgenic Activity of Basella Alba L. (Basellaceae) in Adult Male Rats
Purpose: Solubilizers play an important role in dissolution of pharmacological ingredients and should properly dissolve the active principle(s) while preserving its activities. This study investigated the effect of starch, gelatin, methylcellulose and polyvinylpyrrolidone 10000 in the preservation o...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2017-04-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-7-103.pdf |
| _version_ | 1818783286397239296 |
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| author | Edouard Akono Nantia Faustin Pascal Tsagué Manfo Nathalie Sara E Beboy Paul Fewou Moundipa |
| author_facet | Edouard Akono Nantia Faustin Pascal Tsagué Manfo Nathalie Sara E Beboy Paul Fewou Moundipa |
| author_sort | Edouard Akono Nantia |
| collection | DOAJ |
| description | Purpose: Solubilizers play an important role in dissolution of pharmacological ingredients and should properly dissolve the active principle(s) while preserving its activities. This study investigated the effect of starch, gelatin, methylcellulose and polyvinylpyrrolidone 10000 in the preservation of the androgenic activity of the methanol extract Basella alba (MEBa).
Methods: Different groups of male albino rats were orally given the MEBa (1 mg/kg) dissolved into either 1% gelatin (1% gel), %1 methylcellulose (1% MC) and 1% polyvinylpyrrolidone 10000 (1% PVP 10000) or 2% starch solution (2% SS) for 30 days. Thereafter, animals were sacrificed and serum testosterone and creatinine levels as well as alanine aminotransferase (ALT) activity determined. Vital and reproductive organs were dissected out and weighed, while liver thiobarbituric acid reactive substances (TBARS) and glutathione levels were determined.
Results: Different treatments did not affect the animal body and organ weights. The MEBa stimulatory effect on testosterone production was preserved with 2% SS and 1% PVP 10000 as vehicles. Increased liver glutathione and TBARS levels were also observed in the animals fed with the MEBa dissolved in 2% SS and 1% Gel, respectively, while other biochemical parameters remained unchanged.
Conclusion: Starch and polyvinylpyrrolidone 10000 stand as good preservation agents for MEBa androgenic activity, with starch exhibiting additional antioxidant activity through increase of glutathione levels. |
| first_indexed | 2024-12-18T13:01:47Z |
| format | Article |
| id | doaj.art-98fd398d2df14b6b8925e97844fe1eb5 |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-18T13:01:47Z |
| publishDate | 2017-04-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-98fd398d2df14b6b8925e97844fe1eb52022-12-21T21:07:09ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082017-04-017110310810.15171/apb.2017.013APB_3571_20151011002705Effect of Solubilizers on the Androgenic Activity of Basella Alba L. (Basellaceae) in Adult Male RatsEdouard Akono Nantia0Faustin Pascal Tsagué Manfo1Nathalie Sara E Beboy2Paul Fewou Moundipa3Department of Biochemistry, Faculty of Science, University of Bamenda, Cameroon.Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Cameroon.Laboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaoundé I, Cameroon. Laboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaoundé I, Cameroon. Purpose: Solubilizers play an important role in dissolution of pharmacological ingredients and should properly dissolve the active principle(s) while preserving its activities. This study investigated the effect of starch, gelatin, methylcellulose and polyvinylpyrrolidone 10000 in the preservation of the androgenic activity of the methanol extract Basella alba (MEBa). Methods: Different groups of male albino rats were orally given the MEBa (1 mg/kg) dissolved into either 1% gelatin (1% gel), %1 methylcellulose (1% MC) and 1% polyvinylpyrrolidone 10000 (1% PVP 10000) or 2% starch solution (2% SS) for 30 days. Thereafter, animals were sacrificed and serum testosterone and creatinine levels as well as alanine aminotransferase (ALT) activity determined. Vital and reproductive organs were dissected out and weighed, while liver thiobarbituric acid reactive substances (TBARS) and glutathione levels were determined. Results: Different treatments did not affect the animal body and organ weights. The MEBa stimulatory effect on testosterone production was preserved with 2% SS and 1% PVP 10000 as vehicles. Increased liver glutathione and TBARS levels were also observed in the animals fed with the MEBa dissolved in 2% SS and 1% Gel, respectively, while other biochemical parameters remained unchanged. Conclusion: Starch and polyvinylpyrrolidone 10000 stand as good preservation agents for MEBa androgenic activity, with starch exhibiting additional antioxidant activity through increase of glutathione levels.http://journals.tbzmed.ac.ir/APB/Manuscript/APB-7-103.pdfBasella albaSolubilizerAndrogenic activityMale rat |
| spellingShingle | Edouard Akono Nantia Faustin Pascal Tsagué Manfo Nathalie Sara E Beboy Paul Fewou Moundipa Effect of Solubilizers on the Androgenic Activity of Basella Alba L. (Basellaceae) in Adult Male Rats Advanced Pharmaceutical Bulletin Basella alba Solubilizer Androgenic activity Male rat |
| title | Effect of Solubilizers on the Androgenic Activity of Basella Alba L. (Basellaceae) in Adult Male Rats |
| title_full | Effect of Solubilizers on the Androgenic Activity of Basella Alba L. (Basellaceae) in Adult Male Rats |
| title_fullStr | Effect of Solubilizers on the Androgenic Activity of Basella Alba L. (Basellaceae) in Adult Male Rats |
| title_full_unstemmed | Effect of Solubilizers on the Androgenic Activity of Basella Alba L. (Basellaceae) in Adult Male Rats |
| title_short | Effect of Solubilizers on the Androgenic Activity of Basella Alba L. (Basellaceae) in Adult Male Rats |
| title_sort | effect of solubilizers on the androgenic activity of basella alba l basellaceae in adult male rats |
| topic | Basella alba Solubilizer Androgenic activity Male rat |
| url | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-7-103.pdf |
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