Expression of mRNA IL-17F and sIL-17F in atopic asthma patients
Abstract Background Asthma is a chronic inflammatory disorder of airway that involves many cells and elements. Chronic inflammation caused by increase Airway hyperresponsiveness that cause recurrent episodic symptoms of breathlessness, wheezing, chest tightness and coughing, especially at night or e...
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-017-2517-9 |
| _version_ | 1818514876265398272 |
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| author | Mochammad Hatta Eko E. Surachmanto Andi Asadul Islam Syarifuddin Wahid |
| author_facet | Mochammad Hatta Eko E. Surachmanto Andi Asadul Islam Syarifuddin Wahid |
| author_sort | Mochammad Hatta |
| collection | DOAJ |
| description | Abstract Background Asthma is a chronic inflammatory disorder of airway that involves many cells and elements. Chronic inflammation caused by increase Airway hyperresponsiveness that cause recurrent episodic symptoms of breathlessness, wheezing, chest tightness and coughing, especially at night or early morning. Interleukin 17F is a cytokine that plays an important role in the pathophysiology of asthma attacks. Some studies show a variety of IL-17F roles in the pathogenesis of airway inflammation due to an allergic reaction. Results The study was conducted at the Prof. Dr. R. D. Kandou Manado Hospital, Indonesia. Samples were taken continuously until the number of meant samples was achieved. Blood samples were collected from 40 atopic asthmatic patients. From statistical analysis based on the hypothesis, there was positive correlation between mRNA levels of IL-17F and IL-17F in atopic asthmatic patient (p = 0.000 and r = 0.988). Conclusions According these data suggest that levels of mRNA IL-17F and IL17F might be useful parameters for the diagnosis of atopic asthma patient. |
| first_indexed | 2024-12-11T00:21:41Z |
| format | Article |
| id | doaj.art-98ff6a9b1ef04487a35ab7f99125673f |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-11T00:21:41Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-98ff6a9b1ef04487a35ab7f99125673f2022-12-22T01:27:44ZengBMCBMC Research Notes1756-05002017-06-011011510.1186/s13104-017-2517-9Expression of mRNA IL-17F and sIL-17F in atopic asthma patientsMochammad Hatta0Eko E. Surachmanto1Andi Asadul Islam2Syarifuddin Wahid3Molecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin UniversityAllergy Immunology Division, Department of Internal Medicine, Faculty of Medicine, Sam Ratulangi UniversityDepartment of Neurosurgery, Faculty of Medicine, Hasanuddin UniversityDepartment of Pathology Anatomy, Faculty of Medicine, Hasanuddin UniversityAbstract Background Asthma is a chronic inflammatory disorder of airway that involves many cells and elements. Chronic inflammation caused by increase Airway hyperresponsiveness that cause recurrent episodic symptoms of breathlessness, wheezing, chest tightness and coughing, especially at night or early morning. Interleukin 17F is a cytokine that plays an important role in the pathophysiology of asthma attacks. Some studies show a variety of IL-17F roles in the pathogenesis of airway inflammation due to an allergic reaction. Results The study was conducted at the Prof. Dr. R. D. Kandou Manado Hospital, Indonesia. Samples were taken continuously until the number of meant samples was achieved. Blood samples were collected from 40 atopic asthmatic patients. From statistical analysis based on the hypothesis, there was positive correlation between mRNA levels of IL-17F and IL-17F in atopic asthmatic patient (p = 0.000 and r = 0.988). Conclusions According these data suggest that levels of mRNA IL-17F and IL17F might be useful parameters for the diagnosis of atopic asthma patient.http://link.springer.com/article/10.1186/s13104-017-2517-9mRNA IL-17FSoluble IL-17FAsthmaELISAReal-time PCR |
| spellingShingle | Mochammad Hatta Eko E. Surachmanto Andi Asadul Islam Syarifuddin Wahid Expression of mRNA IL-17F and sIL-17F in atopic asthma patients BMC Research Notes mRNA IL-17F Soluble IL-17F Asthma ELISA Real-time PCR |
| title | Expression of mRNA IL-17F and sIL-17F in atopic asthma patients |
| title_full | Expression of mRNA IL-17F and sIL-17F in atopic asthma patients |
| title_fullStr | Expression of mRNA IL-17F and sIL-17F in atopic asthma patients |
| title_full_unstemmed | Expression of mRNA IL-17F and sIL-17F in atopic asthma patients |
| title_short | Expression of mRNA IL-17F and sIL-17F in atopic asthma patients |
| title_sort | expression of mrna il 17f and sil 17f in atopic asthma patients |
| topic | mRNA IL-17F Soluble IL-17F Asthma ELISA Real-time PCR |
| url | http://link.springer.com/article/10.1186/s13104-017-2517-9 |
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