African swine fever virus QP383R dampens type I interferon production by promoting cGAS palmitoylation

Cyclic GMP-AMP synthase (cGAS) recognizes viral DNA and synthesizes cyclic GMP-AMP (cGAMP), which activates stimulator of interferon genes (STING/MITA) and downstream mediators to elicit an innate immune response. African swine fever virus (ASFV) proteins can antagonize host immune responses to prom...

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Bibliographic Details
Main Authors: Siyuan Hao, Xiaojie Zheng, Yingqi Zhu, Yao Yao, Sihan Li, Yangyang Xu, Wen-hai Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1186916/full