Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus
Abstract Dengue virus (DENV) is one of the most important arboviral pathogens in the tropics and subtropics, and nearly one‐third of the world's population is at risk of infection. The transmission of DENV involves a sylvatic cycle between nonhuman primates (NHP) and Aedes genus mosquitoes, and...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-10-01
|
| Series: | Animal Models and Experimental Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ame2.12283 |
| _version_ | 1811257563527774208 |
|---|---|
| author | Xi Yu Gong Cheng |
| author_facet | Xi Yu Gong Cheng |
| author_sort | Xi Yu |
| collection | DOAJ |
| description | Abstract Dengue virus (DENV) is one of the most important arboviral pathogens in the tropics and subtropics, and nearly one‐third of the world's population is at risk of infection. The transmission of DENV involves a sylvatic cycle between nonhuman primates (NHP) and Aedes genus mosquitoes, and an endemic cycle between human hosts and predominantly Aedes aegypti. DENV belongs to the genus Flavivirus of the family Flaviviridae and consists of four antigenically distinct serotypes (DENV‐1‐4). Phylogenetic analyses of DENV have revealed its origin, epidemiology, and the drivers that determine its molecular evolution in nature. This review discusses how phylogenetic research has improved our understanding of DENV evolution and how it affects viral ecology and improved our ability to analyze and predict future DENV emergence. |
| first_indexed | 2024-04-12T17:59:29Z |
| format | Article |
| id | doaj.art-99024f91f4ee4caab3802e3e69d61740 |
| institution | Directory Open Access Journal |
| issn | 2576-2095 |
| language | English |
| last_indexed | 2024-04-12T17:59:29Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj.art-99024f91f4ee4caab3802e3e69d617402022-12-22T03:22:13ZengWileyAnimal Models and Experimental Medicine2576-20952022-10-015541041710.1002/ame2.12283Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virusXi Yu0Gong Cheng1Tsinghua‐Peking Center for Life Sciences, School of Medicine Tsinghua University Beijing ChinaTsinghua‐Peking Center for Life Sciences, School of Medicine Tsinghua University Beijing ChinaAbstract Dengue virus (DENV) is one of the most important arboviral pathogens in the tropics and subtropics, and nearly one‐third of the world's population is at risk of infection. The transmission of DENV involves a sylvatic cycle between nonhuman primates (NHP) and Aedes genus mosquitoes, and an endemic cycle between human hosts and predominantly Aedes aegypti. DENV belongs to the genus Flavivirus of the family Flaviviridae and consists of four antigenically distinct serotypes (DENV‐1‐4). Phylogenetic analyses of DENV have revealed its origin, epidemiology, and the drivers that determine its molecular evolution in nature. This review discusses how phylogenetic research has improved our understanding of DENV evolution and how it affects viral ecology and improved our ability to analyze and predict future DENV emergence.https://doi.org/10.1002/ame2.12283dengue virus (DENV)evolutionflavivirusphylogenetics |
| spellingShingle | Xi Yu Gong Cheng Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus Animal Models and Experimental Medicine dengue virus (DENV) evolution flavivirus phylogenetics |
| title | Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus |
| title_full | Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus |
| title_fullStr | Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus |
| title_full_unstemmed | Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus |
| title_short | Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus |
| title_sort | contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus |
| topic | dengue virus (DENV) evolution flavivirus phylogenetics |
| url | https://doi.org/10.1002/ame2.12283 |
| work_keys_str_mv | AT xiyu contributionofphylogeneticstounderstandingtheevolutionandepidemiologyofdenguevirus AT gongcheng contributionofphylogeneticstounderstandingtheevolutionandepidemiologyofdenguevirus |