Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke

Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke

Heat stroke (HS) is a severe condition characterized by increased morbidity and high mortality. Acute liver injury (ALI) is a well-documented complication of HS. The tumor suppressor p53 plays an important role in regulation of mitochondrial integrity and mitophagy in several forms of ALI. However,...

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Bibliographic Details
Main Authors: Wei Huang, Weidang Xie, Hanhui Zhong, Shumin Cai, Qiaobing Huang, Youtan Liu, Zhenhua Zeng, Yanan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
mitophagy
acute liver injury
p53
Parkin
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.859231/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.859231/full

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