Prediction of Rupture by Complete Blood Count in Tubal Ectopic Pregnancies Treated with a Single-Dose Methotrexate Protocol
Abstract Objective The availability of reliable and inexpensive markers that can be used to determine the risk of rupture during methotrexate (MTX) treatment in ectopic pregnancies (EPs) is considerable. The aim of the present study is to investigate the role of systemic inflammatory markers such a...
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| Format: | Article |
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2023-10-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032023000900503&lng=en&tlng=en |
| _version_ | 1797644563626590208 |
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| author | Yıldız Akdaş Reis Arife Akay Elif Gülşah Diktaş Merve Özkan Neslihan Öztürk Doğukan Özkan Betül Tokgöz Çakır Salim Erkaya |
| author_facet | Yıldız Akdaş Reis Arife Akay Elif Gülşah Diktaş Merve Özkan Neslihan Öztürk Doğukan Özkan Betül Tokgöz Çakır Salim Erkaya |
| author_sort | Yıldız Akdaş Reis |
| collection | DOAJ |
| description | Abstract Objective The availability of reliable and inexpensive markers that can be used to determine the risk of rupture during methotrexate (MTX) treatment in ectopic pregnancies (EPs) is considerable. The aim of the present study is to investigate the role of systemic inflammatory markers such as leukocytes (or white blood cells, WBCs), the neutrophil-to-lymphocyte ratio (NLR), and platelet distribution width (PDW), which are among the parameters of the complete blood count (CBC), in the prediction of rupture of EPs under MTX treatment. Materials and Methods A total of 161 patients with tubal EP who underwent a single-dose methotrexate (MTX) protocol were retrospectively analyzed, and the control group (n = 83) included patients cured by MTX, while the ruptured group (n = 78) included patients who were operated on for tubal rupture during the MTX treatment. The features of EP, beta-human chorionic gonadotropin (β-hCG) levels, sonographic findings, and CBC-derived markers such as WBC, NLR, and PDW, were investigated by comparing both groups. Results The NLR was found to be higher in the ruptured group, of 2.92 ± 0.86%, and significantly lower in the control group, of 2.09 ± 0.6%. Similarly, the PDW was higher (51 ± 9%) in the ruptured group, and it was significantly lower a (47 ± 13%) in the control group (p < 0.05). Other CBC parameters were similar in both groups (p > 0.05). Conclusion Systemic inflammation markers derived from CBC can be easily applied to predict the risk of tubal rupture in Eps, since the CBC is an inexpensive and easy-to-apply test, which is first requested from each patient during hospitalization. |
| first_indexed | 2024-03-11T14:32:25Z |
| format | Article |
| id | doaj.art-9902cfd3c30f4b7c8967f3e7cc12143a |
| institution | Directory Open Access Journal |
| issn | 0100-7203 |
| language | English |
| last_indexed | 2024-03-11T14:32:25Z |
| publishDate | 2023-10-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj.art-9902cfd3c30f4b7c8967f3e7cc12143a2023-10-31T07:50:43ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032023-10-0145950351010.1055/s-0043-1772485Prediction of Rupture by Complete Blood Count in Tubal Ectopic Pregnancies Treated with a Single-Dose Methotrexate ProtocolYıldız Akdaş Reishttps://orcid.org/0000-0001-9345-6899Arife Akayhttps://orcid.org/0000-0001-9640-2714Elif Gülşah Diktaşhttps://orcid.org/0000-0002-2869-6914Merve Özkanhttps://orcid.org/0000-0002-3344-2804Neslihan Öztürkhttps://orcid.org/0000-0002-5578-8718Doğukan Özkanhttps://orcid.org/0000-0002-4202-1681Betül Tokgöz ÇakırSalim Erkayahttps://orcid.org/0000-0003-0331-952XAbstract Objective The availability of reliable and inexpensive markers that can be used to determine the risk of rupture during methotrexate (MTX) treatment in ectopic pregnancies (EPs) is considerable. The aim of the present study is to investigate the role of systemic inflammatory markers such as leukocytes (or white blood cells, WBCs), the neutrophil-to-lymphocyte ratio (NLR), and platelet distribution width (PDW), which are among the parameters of the complete blood count (CBC), in the prediction of rupture of EPs under MTX treatment. Materials and Methods A total of 161 patients with tubal EP who underwent a single-dose methotrexate (MTX) protocol were retrospectively analyzed, and the control group (n = 83) included patients cured by MTX, while the ruptured group (n = 78) included patients who were operated on for tubal rupture during the MTX treatment. The features of EP, beta-human chorionic gonadotropin (β-hCG) levels, sonographic findings, and CBC-derived markers such as WBC, NLR, and PDW, were investigated by comparing both groups. Results The NLR was found to be higher in the ruptured group, of 2.92 ± 0.86%, and significantly lower in the control group, of 2.09 ± 0.6%. Similarly, the PDW was higher (51 ± 9%) in the ruptured group, and it was significantly lower a (47 ± 13%) in the control group (p < 0.05). Other CBC parameters were similar in both groups (p > 0.05). Conclusion Systemic inflammation markers derived from CBC can be easily applied to predict the risk of tubal rupture in Eps, since the CBC is an inexpensive and easy-to-apply test, which is first requested from each patient during hospitalization.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032023000900503&lng=en&tlng=enectopic pregnancymethotrexateneutrophil-to-lymphocyte ratioplatelet distribution width |
| spellingShingle | Yıldız Akdaş Reis Arife Akay Elif Gülşah Diktaş Merve Özkan Neslihan Öztürk Doğukan Özkan Betül Tokgöz Çakır Salim Erkaya Prediction of Rupture by Complete Blood Count in Tubal Ectopic Pregnancies Treated with a Single-Dose Methotrexate Protocol Revista Brasileira de Ginecologia e Obstetrícia ectopic pregnancy methotrexate neutrophil-to-lymphocyte ratio platelet distribution width |
| title | Prediction of Rupture by Complete Blood Count in Tubal Ectopic Pregnancies Treated with a Single-Dose Methotrexate Protocol |
| title_full | Prediction of Rupture by Complete Blood Count in Tubal Ectopic Pregnancies Treated with a Single-Dose Methotrexate Protocol |
| title_fullStr | Prediction of Rupture by Complete Blood Count in Tubal Ectopic Pregnancies Treated with a Single-Dose Methotrexate Protocol |
| title_full_unstemmed | Prediction of Rupture by Complete Blood Count in Tubal Ectopic Pregnancies Treated with a Single-Dose Methotrexate Protocol |
| title_short | Prediction of Rupture by Complete Blood Count in Tubal Ectopic Pregnancies Treated with a Single-Dose Methotrexate Protocol |
| title_sort | prediction of rupture by complete blood count in tubal ectopic pregnancies treated with a single dose methotrexate protocol |
| topic | ectopic pregnancy methotrexate neutrophil-to-lymphocyte ratio platelet distribution width |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032023000900503&lng=en&tlng=en |
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