Spatiotemporal Analysis of Hydration Mechanism in Sodium Alginate Matrix Tablets
Methods of spatiotemporal characterization of nonequilibrated polymer based matrices are still immature and imperfect. The purpose of the study was to develop the methodology for the spatiotemporal characterization of water transport and properties in alginate tablets under hydration. The regions of...
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MDPI AG
2021-01-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/14/3/646 |
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| author | Ewelina Juszczyk Piotr Kulinowski Ewelina Baran Artur Birczyński Dorota Majda Encarna García-Montoya Pilar Pérez-Lozano Josep Maria Suñé-Negre Władysław P. Węglarz Przemysław Dorożyński |
| author_facet | Ewelina Juszczyk Piotr Kulinowski Ewelina Baran Artur Birczyński Dorota Majda Encarna García-Montoya Pilar Pérez-Lozano Josep Maria Suñé-Negre Władysław P. Węglarz Przemysław Dorożyński |
| author_sort | Ewelina Juszczyk |
| collection | DOAJ |
| description | Methods of spatiotemporal characterization of nonequilibrated polymer based matrices are still immature and imperfect. The purpose of the study was to develop the methodology for the spatiotemporal characterization of water transport and properties in alginate tablets under hydration. The regions of low water content were spatially and temporally sampled using Karl Fisher and Differential Scanning Callorimetry (spatial distribution of freezing/nonfreezing water) with spatial resolution of 1 mm. In the regions of high water content, where sampling was infeasible due to gel/sol consistency, magnetic resonance imaging (MRI) enabled characterization with an order of magnitude higher spatial resolution. The minimally hydrated layer (MHL), infiltration layer (IL) and fully hydrated layer (FHL) were identified in the unilaterally hydrated matrices. The MHL gained water from the first hour of incubation (5–10% <i>w</i>/<i>w</i>) and at 4 h total water content was 29–39% with nonfreezing pool of 28–29%. The water content in the IL was 45–47% and at 4 h it reached ~50% with the nonfreezing pool of 28% and T<sub>2</sub> relaxation time < 10 ms. The FHL consisted of gel and sol layer with water content of 85–86% with a nonfreezing pool of 11% at 4 h and T<sub>2</sub> in the range 20–200 ms. Hybrid destructive/nondestructive analysis of alginate matrices under hydration was proposed. It allowed assessing the temporal changes of water distribution, its mobility and interaction with matrices in identified layers. |
| first_indexed | 2024-03-09T06:20:56Z |
| format | Article |
| id | doaj.art-99042ed60c2244b3b276ae08eb1c1535 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-09T06:20:56Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-99042ed60c2244b3b276ae08eb1c15352023-12-03T11:47:24ZengMDPI AGMaterials1996-19442021-01-0114364610.3390/ma14030646Spatiotemporal Analysis of Hydration Mechanism in Sodium Alginate Matrix TabletsEwelina Juszczyk0Piotr Kulinowski1Ewelina Baran2Artur Birczyński3Dorota Majda4Encarna García-Montoya5Pilar Pérez-Lozano6Josep Maria Suñé-Negre7Władysław P. Węglarz8Przemysław Dorożyński9Research and Development Center, Celon Pharma S.A., Marymoncka 15, 05-152 Kazuń Nowy, PolandInstitute of Technology, The Pedagogical University of Kraków, Podchorążych 2, 30-084 Kraków, PolandInstitute of Technology, The Pedagogical University of Kraków, Podchorążych 2, 30-084 Kraków, PolandInstitute of Technology, The Pedagogical University of Kraków, Podchorążych 2, 30-084 Kraków, PolandFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, PolandPharmaceutical Technology and Physico-Chemical Department, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, SpainPharmaceutical Technology and Physico-Chemical Department, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, SpainPharmaceutical Technology and Physico-Chemical Department, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, SpainDepartment of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, Radzikowskiego 152, 31-342 Kraków, PolandDepartment of Drug Technology and Pharmaceutical Biotechnology, Medical University of Warsaw, Banacha 1, 02-097 Warszawa, PolandMethods of spatiotemporal characterization of nonequilibrated polymer based matrices are still immature and imperfect. The purpose of the study was to develop the methodology for the spatiotemporal characterization of water transport and properties in alginate tablets under hydration. The regions of low water content were spatially and temporally sampled using Karl Fisher and Differential Scanning Callorimetry (spatial distribution of freezing/nonfreezing water) with spatial resolution of 1 mm. In the regions of high water content, where sampling was infeasible due to gel/sol consistency, magnetic resonance imaging (MRI) enabled characterization with an order of magnitude higher spatial resolution. The minimally hydrated layer (MHL), infiltration layer (IL) and fully hydrated layer (FHL) were identified in the unilaterally hydrated matrices. The MHL gained water from the first hour of incubation (5–10% <i>w</i>/<i>w</i>) and at 4 h total water content was 29–39% with nonfreezing pool of 28–29%. The water content in the IL was 45–47% and at 4 h it reached ~50% with the nonfreezing pool of 28% and T<sub>2</sub> relaxation time < 10 ms. The FHL consisted of gel and sol layer with water content of 85–86% with a nonfreezing pool of 11% at 4 h and T<sub>2</sub> in the range 20–200 ms. Hybrid destructive/nondestructive analysis of alginate matrices under hydration was proposed. It allowed assessing the temporal changes of water distribution, its mobility and interaction with matrices in identified layers.https://www.mdpi.com/1996-1944/14/3/646sodium alginatemass transportwater–polymer interactionspatial water distributioncompressed matrix tabletshydrophilic polymeric matrices |
| spellingShingle | Ewelina Juszczyk Piotr Kulinowski Ewelina Baran Artur Birczyński Dorota Majda Encarna García-Montoya Pilar Pérez-Lozano Josep Maria Suñé-Negre Władysław P. Węglarz Przemysław Dorożyński Spatiotemporal Analysis of Hydration Mechanism in Sodium Alginate Matrix Tablets Materials sodium alginate mass transport water–polymer interaction spatial water distribution compressed matrix tablets hydrophilic polymeric matrices |
| title | Spatiotemporal Analysis of Hydration Mechanism in Sodium Alginate Matrix Tablets |
| title_full | Spatiotemporal Analysis of Hydration Mechanism in Sodium Alginate Matrix Tablets |
| title_fullStr | Spatiotemporal Analysis of Hydration Mechanism in Sodium Alginate Matrix Tablets |
| title_full_unstemmed | Spatiotemporal Analysis of Hydration Mechanism in Sodium Alginate Matrix Tablets |
| title_short | Spatiotemporal Analysis of Hydration Mechanism in Sodium Alginate Matrix Tablets |
| title_sort | spatiotemporal analysis of hydration mechanism in sodium alginate matrix tablets |
| topic | sodium alginate mass transport water–polymer interaction spatial water distribution compressed matrix tablets hydrophilic polymeric matrices |
| url | https://www.mdpi.com/1996-1944/14/3/646 |
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