Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control
Uncontrolled type-1 diabetes (T1DM) can lead to dyslipidaemia and albuminuria, which may promote cardiovascular injuries. However, some lipidemic factors could be useful in predicting cardiac dysfunction. Seventy-eight adolescents under insulin treatment due to a 6-year history of T1DM and were retr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/14/5079 |
| _version_ | 1797562112281673728 |
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| author | Dina Khedr Mona Hafez Jairo Lumpuy-Castillo Soha Emam Antoine Abdel-Massih Fatma Elmougy Rasha Elkaffas Ignacio Mahillo-Fernández Oscar Lorenzo Noha Musa |
| author_facet | Dina Khedr Mona Hafez Jairo Lumpuy-Castillo Soha Emam Antoine Abdel-Massih Fatma Elmougy Rasha Elkaffas Ignacio Mahillo-Fernández Oscar Lorenzo Noha Musa |
| author_sort | Dina Khedr |
| collection | DOAJ |
| description | Uncontrolled type-1 diabetes (T1DM) can lead to dyslipidaemia and albuminuria, which may promote cardiovascular injuries. However, some lipidemic factors could be useful in predicting cardiac dysfunction. Seventy-eight adolescents under insulin treatment due to a 6-year history of T1DM and were retrospectively examined. Glycemia, lipidemia, and albuminuria were measured in addition to development of cardiovascular abnormalities Both girls and boys showed higher HbA1c and fasting blood glucose and 27.1% females and 33.3% males exhibited microalbuminuria though their plasma levels of total cholesterol (TC), triglycerides (TG), and low-density lipoproteins (LDL) and high-density lipoproteins (HDL lipoproteins were in the normal range. They exhibited a preserved systolic function, but 50% of females and 66.6% of males had developed diastolic failures. Interestingly, girls with diastolic dysfunction showed significantly lower concentrations of HDL and higher TC/HDL and TG/HDL ratios. In fact, low HDL levels (OR 0.93; 95% CI 0.88–0.99; <i>p</i> = 0.029) and high TC/HDL (OR 2.55; 95% CI 1.9–5.45; <i>p</i> = 0.016) and TG/HDL (OR 2.74; 95% CI 1.12–6.71; <i>p</i> = 0.028) ratios associated with the development of diastolic complications. The cut-off values for HDL, TC/HDL, and TG/HDL were 49 mg/dL, 3.0 and 1.85, respectively. HDL and TC/HDL and TG/HDL ratios may be useful for predicting diastolic dysfunction in girls with uncontrolled T1DM. |
| first_indexed | 2024-03-10T18:23:54Z |
| format | Article |
| id | doaj.art-990504e55bb2495aa28609f83cdd8cc7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:23:54Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-990504e55bb2495aa28609f83cdd8cc72023-11-20T07:11:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012114507910.3390/ijms21145079Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic ControlDina Khedr0Mona Hafez1Jairo Lumpuy-Castillo2Soha Emam3Antoine Abdel-Massih4Fatma Elmougy5Rasha Elkaffas6Ignacio Mahillo-Fernández7Oscar Lorenzo8Noha Musa9Pediatric Diabetes, Endocrine and Metabolism Unit, Children Hospital, Cairo University, Cairo 12664, EgyptPediatric Diabetes, Endocrine and Metabolism Unit, Children Hospital, Cairo University, Cairo 12664, EgyptLaboratory of Diabetes Research, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, SpainPediatric Cardiology Unit, Children’s Hospital, Cairo University, Cairo 12664, EgyptPediatric Cardiology Unit, Children’s Hospital, Cairo University, Cairo 12664, EgyptDepartment of Clinical and Chemical Pathology, Cairo University, Cairo 12664, EgyptDepartment of Clinical and Chemical Pathology, Cairo University, Cairo 12664, EgyptStatistics Department, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, SpainLaboratory of Diabetes Research, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, SpainPediatric Diabetes, Endocrine and Metabolism Unit, Children Hospital, Cairo University, Cairo 12664, EgyptUncontrolled type-1 diabetes (T1DM) can lead to dyslipidaemia and albuminuria, which may promote cardiovascular injuries. However, some lipidemic factors could be useful in predicting cardiac dysfunction. Seventy-eight adolescents under insulin treatment due to a 6-year history of T1DM and were retrospectively examined. Glycemia, lipidemia, and albuminuria were measured in addition to development of cardiovascular abnormalities Both girls and boys showed higher HbA1c and fasting blood glucose and 27.1% females and 33.3% males exhibited microalbuminuria though their plasma levels of total cholesterol (TC), triglycerides (TG), and low-density lipoproteins (LDL) and high-density lipoproteins (HDL lipoproteins were in the normal range. They exhibited a preserved systolic function, but 50% of females and 66.6% of males had developed diastolic failures. Interestingly, girls with diastolic dysfunction showed significantly lower concentrations of HDL and higher TC/HDL and TG/HDL ratios. In fact, low HDL levels (OR 0.93; 95% CI 0.88–0.99; <i>p</i> = 0.029) and high TC/HDL (OR 2.55; 95% CI 1.9–5.45; <i>p</i> = 0.016) and TG/HDL (OR 2.74; 95% CI 1.12–6.71; <i>p</i> = 0.028) ratios associated with the development of diastolic complications. The cut-off values for HDL, TC/HDL, and TG/HDL were 49 mg/dL, 3.0 and 1.85, respectively. HDL and TC/HDL and TG/HDL ratios may be useful for predicting diastolic dysfunction in girls with uncontrolled T1DM.https://www.mdpi.com/1422-0067/21/14/5079type-I diabetescardiac dysfunctionHDLtriglyceridescholesterol |
| spellingShingle | Dina Khedr Mona Hafez Jairo Lumpuy-Castillo Soha Emam Antoine Abdel-Massih Fatma Elmougy Rasha Elkaffas Ignacio Mahillo-Fernández Oscar Lorenzo Noha Musa Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control International Journal of Molecular Sciences type-I diabetes cardiac dysfunction HDL triglycerides cholesterol |
| title | Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control |
| title_full | Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control |
| title_fullStr | Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control |
| title_full_unstemmed | Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control |
| title_short | Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control |
| title_sort | lipid biomarkers as predictors of diastolic dysfunction in diabetes with poor glycemic control |
| topic | type-I diabetes cardiac dysfunction HDL triglycerides cholesterol |
| url | https://www.mdpi.com/1422-0067/21/14/5079 |
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