Does electrical stimulation in the lower urinary tract increase urine production? A randomised comparative proof-of-concept study in healthy volunteers.
<h4>Trial design</h4>During electrical stimulation in the lower urinary tract for the purpose of current perception threshold and sensory evoked potential recording, we observed that bladder volume increased rapidly. The aim of this prospective randomised comparative proof-of-concept stu...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0217503 |
| _version_ | 1818444294289096704 |
|---|---|
| author | Stéphanie van der Lely Martina D Liechti Werner L Popp Melanie R Schmidhalter Thomas M Kessler Ulrich Mehnert |
| author_facet | Stéphanie van der Lely Martina D Liechti Werner L Popp Melanie R Schmidhalter Thomas M Kessler Ulrich Mehnert |
| author_sort | Stéphanie van der Lely |
| collection | DOAJ |
| description | <h4>Trial design</h4>During electrical stimulation in the lower urinary tract for the purpose of current perception threshold and sensory evoked potential recording, we observed that bladder volume increased rapidly. The aim of this prospective randomised comparative proof-of-concept study was to quantify urine production per time during stimulation of the lower urinary tract using different stimulation frequencies.<h4>Methods</h4>Ninety healthy subjects (18 to 36 years old) were included. Forty females and 50 males were randomly assigned to one of the following study groups: dome, trigone or proximal, membranous (males only) or distal urethra. Starting from 60mL prefilling, stimulation was performed at two separate visits with a 14 French custom-made catheter using randomly applied frequencies of 0.5Hz, 1.1Hz, 1.6Hz (each with 500 stimuli). After each stimulation cycle per frequency, urine production was assessed. Main outcome measures represented urine production during stimulation, daily life and their ratio.<h4>Results</h4>Lower urinary tract electrical stimulation increased urine production per time compared to bladder diary baseline values. Linear mixed model showed that frequency (p<0.001), stimulation order (p = 0.003), intensity (p = 0.042), and gender (p = 0.047) had a significant influence on urine production. Location, visit and age had no significant influence.<h4>Conclusions</h4>Urine production is increased during electrical stimulation with a bigger impact of higher frequencies. This might be relevant for methodological aspects in the assessment of lower urinary tract afferent function and for patients with impaired renal urine output. Inhibition of renal sympathetic nerve activity by vagal afferents may be the underlying mechanism. |
| first_indexed | 2024-12-14T19:13:39Z |
| format | Article |
| id | doaj.art-9905ae0f018141cd8f16029d827429ed |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T19:13:39Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9905ae0f018141cd8f16029d827429ed2022-12-21T22:50:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01145e021750310.1371/journal.pone.0217503Does electrical stimulation in the lower urinary tract increase urine production? A randomised comparative proof-of-concept study in healthy volunteers.Stéphanie van der LelyMartina D LiechtiWerner L PoppMelanie R SchmidhalterThomas M KesslerUlrich Mehnert<h4>Trial design</h4>During electrical stimulation in the lower urinary tract for the purpose of current perception threshold and sensory evoked potential recording, we observed that bladder volume increased rapidly. The aim of this prospective randomised comparative proof-of-concept study was to quantify urine production per time during stimulation of the lower urinary tract using different stimulation frequencies.<h4>Methods</h4>Ninety healthy subjects (18 to 36 years old) were included. Forty females and 50 males were randomly assigned to one of the following study groups: dome, trigone or proximal, membranous (males only) or distal urethra. Starting from 60mL prefilling, stimulation was performed at two separate visits with a 14 French custom-made catheter using randomly applied frequencies of 0.5Hz, 1.1Hz, 1.6Hz (each with 500 stimuli). After each stimulation cycle per frequency, urine production was assessed. Main outcome measures represented urine production during stimulation, daily life and their ratio.<h4>Results</h4>Lower urinary tract electrical stimulation increased urine production per time compared to bladder diary baseline values. Linear mixed model showed that frequency (p<0.001), stimulation order (p = 0.003), intensity (p = 0.042), and gender (p = 0.047) had a significant influence on urine production. Location, visit and age had no significant influence.<h4>Conclusions</h4>Urine production is increased during electrical stimulation with a bigger impact of higher frequencies. This might be relevant for methodological aspects in the assessment of lower urinary tract afferent function and for patients with impaired renal urine output. Inhibition of renal sympathetic nerve activity by vagal afferents may be the underlying mechanism.https://doi.org/10.1371/journal.pone.0217503 |
| spellingShingle | Stéphanie van der Lely Martina D Liechti Werner L Popp Melanie R Schmidhalter Thomas M Kessler Ulrich Mehnert Does electrical stimulation in the lower urinary tract increase urine production? A randomised comparative proof-of-concept study in healthy volunteers. PLoS ONE |
| title | Does electrical stimulation in the lower urinary tract increase urine production? A randomised comparative proof-of-concept study in healthy volunteers. |
| title_full | Does electrical stimulation in the lower urinary tract increase urine production? A randomised comparative proof-of-concept study in healthy volunteers. |
| title_fullStr | Does electrical stimulation in the lower urinary tract increase urine production? A randomised comparative proof-of-concept study in healthy volunteers. |
| title_full_unstemmed | Does electrical stimulation in the lower urinary tract increase urine production? A randomised comparative proof-of-concept study in healthy volunteers. |
| title_short | Does electrical stimulation in the lower urinary tract increase urine production? A randomised comparative proof-of-concept study in healthy volunteers. |
| title_sort | does electrical stimulation in the lower urinary tract increase urine production a randomised comparative proof of concept study in healthy volunteers |
| url | https://doi.org/10.1371/journal.pone.0217503 |
| work_keys_str_mv | AT stephanievanderlely doeselectricalstimulationinthelowerurinarytractincreaseurineproductionarandomisedcomparativeproofofconceptstudyinhealthyvolunteers AT martinadliechti doeselectricalstimulationinthelowerurinarytractincreaseurineproductionarandomisedcomparativeproofofconceptstudyinhealthyvolunteers AT wernerlpopp doeselectricalstimulationinthelowerurinarytractincreaseurineproductionarandomisedcomparativeproofofconceptstudyinhealthyvolunteers AT melanierschmidhalter doeselectricalstimulationinthelowerurinarytractincreaseurineproductionarandomisedcomparativeproofofconceptstudyinhealthyvolunteers AT thomasmkessler doeselectricalstimulationinthelowerurinarytractincreaseurineproductionarandomisedcomparativeproofofconceptstudyinhealthyvolunteers AT ulrichmehnert doeselectricalstimulationinthelowerurinarytractincreaseurineproductionarandomisedcomparativeproofofconceptstudyinhealthyvolunteers |