Carotenoids from Starfish <i>Patiria pectinifera</i>: Therapeutic Activity in Models of Inflammatory Diseases
The carotenoids mixture (MC) isolated from the starfish <i>Patiria. pectinifera</i> contains more than 50% astaxanthin, 4–6% each zeaxanthine and lutein, and less pharmacologically active components such as free fatty acids and their glycerides. Astaxanthin, the major component of MC, be...
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MDPI AG
2023-08-01
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| Series: | Marine Drugs |
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| author | Aleksandr M. Popov Emma P. Kozlovskaya Anna A. Klimovich Tatyana A. Rutckova Aleksey I. Vakhrushev Dmitry M. Hushpulian Irina G. Gazaryan Vyacheslav V. Makhankov Oksana M. Son Liudmila A. Tekutyeva |
| author_facet | Aleksandr M. Popov Emma P. Kozlovskaya Anna A. Klimovich Tatyana A. Rutckova Aleksey I. Vakhrushev Dmitry M. Hushpulian Irina G. Gazaryan Vyacheslav V. Makhankov Oksana M. Son Liudmila A. Tekutyeva |
| author_sort | Aleksandr M. Popov |
| collection | DOAJ |
| description | The carotenoids mixture (MC) isolated from the starfish <i>Patiria. pectinifera</i> contains more than 50% astaxanthin, 4–6% each zeaxanthine and lutein, and less pharmacologically active components such as free fatty acids and their glycerides. Astaxanthin, the major component of MC, belongs to the xanthophyll class of carotenoids, and is well known for its antioxidant properties. In this work, in vitro and in vivo studies on the biological activity of MC were carried out. The complex was shown to exhibit anti-inflammatory, anti-allergic and cancer-preventive activity, without any toxicity at a dose of 500 mg/kg. MC effectively improves the clinical picture of the disease progressing, as well as normalizing the cytokine profile and the antioxidant defense system in the in vivo animal models of inflammatory diseases, namely: skin carcinogenesis, allergic contact dermatitis (ACD) and systemic inflammation (SI). In the skin carcinogenesis induced by 7,12-dimethylbenzanthracene, the incidence of papillomas was decreased 1.5 times; 1% MC ointment form in allergic contact dermatitis showed an 80% reduced severity of pathomorphological skin manifestations. Obtained results show that MC from starfish <i>P. pectinifera</i> is an effective remedy for the treatment and prevention of inflammatory processes. |
| first_indexed | 2024-03-10T22:31:17Z |
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| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T22:31:17Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-9905d41315a0467590771a46a85a40a62023-11-19T11:42:02ZengMDPI AGMarine Drugs1660-33972023-08-0121947010.3390/md21090470Carotenoids from Starfish <i>Patiria pectinifera</i>: Therapeutic Activity in Models of Inflammatory DiseasesAleksandr M. Popov0Emma P. Kozlovskaya1Anna A. Klimovich2Tatyana A. Rutckova3Aleksey I. Vakhrushev4Dmitry M. Hushpulian5Irina G. Gazaryan6Vyacheslav V. Makhankov7Oksana M. Son8Liudmila A. Tekutyeva9G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-letiya Vladivostoka, Vladivostok 690022, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-letiya Vladivostoka, Vladivostok 690022, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-letiya Vladivostoka, Vladivostok 690022, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-letiya Vladivostoka, Vladivostok 690022, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-letiya Vladivostoka, Vladivostok 690022, RussiaFaculty of Biology and Biotechnology, National Research University Higher School of Economics, 13/4 Myasnitskaya str., Moscow 117997, RussiaFaculty of Biology and Biotechnology, National Research University Higher School of Economics, 13/4 Myasnitskaya str., Moscow 117997, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-letiya Vladivostoka, Vladivostok 690022, RussiaSchool of Advanced Engineering Studies, Institute of Biotechnology, Bioengineering and Food Systems, Far Eastern Federal University, p. Ajax 10, Russky Island, Vladivostok 690922, RussiaSchool of Advanced Engineering Studies, Institute of Biotechnology, Bioengineering and Food Systems, Far Eastern Federal University, p. Ajax 10, Russky Island, Vladivostok 690922, RussiaThe carotenoids mixture (MC) isolated from the starfish <i>Patiria. pectinifera</i> contains more than 50% astaxanthin, 4–6% each zeaxanthine and lutein, and less pharmacologically active components such as free fatty acids and their glycerides. Astaxanthin, the major component of MC, belongs to the xanthophyll class of carotenoids, and is well known for its antioxidant properties. In this work, in vitro and in vivo studies on the biological activity of MC were carried out. The complex was shown to exhibit anti-inflammatory, anti-allergic and cancer-preventive activity, without any toxicity at a dose of 500 mg/kg. MC effectively improves the clinical picture of the disease progressing, as well as normalizing the cytokine profile and the antioxidant defense system in the in vivo animal models of inflammatory diseases, namely: skin carcinogenesis, allergic contact dermatitis (ACD) and systemic inflammation (SI). In the skin carcinogenesis induced by 7,12-dimethylbenzanthracene, the incidence of papillomas was decreased 1.5 times; 1% MC ointment form in allergic contact dermatitis showed an 80% reduced severity of pathomorphological skin manifestations. Obtained results show that MC from starfish <i>P. pectinifera</i> is an effective remedy for the treatment and prevention of inflammatory processes.https://www.mdpi.com/1660-3397/21/9/470carotenoids mixture (MC)starfish <i>Patiria pectinifera</i>astaxanthintherapeutic activityinflammatory diseases |
| spellingShingle | Aleksandr M. Popov Emma P. Kozlovskaya Anna A. Klimovich Tatyana A. Rutckova Aleksey I. Vakhrushev Dmitry M. Hushpulian Irina G. Gazaryan Vyacheslav V. Makhankov Oksana M. Son Liudmila A. Tekutyeva Carotenoids from Starfish <i>Patiria pectinifera</i>: Therapeutic Activity in Models of Inflammatory Diseases Marine Drugs carotenoids mixture (MC) starfish <i>Patiria pectinifera</i> astaxanthin therapeutic activity inflammatory diseases |
| title | Carotenoids from Starfish <i>Patiria pectinifera</i>: Therapeutic Activity in Models of Inflammatory Diseases |
| title_full | Carotenoids from Starfish <i>Patiria pectinifera</i>: Therapeutic Activity in Models of Inflammatory Diseases |
| title_fullStr | Carotenoids from Starfish <i>Patiria pectinifera</i>: Therapeutic Activity in Models of Inflammatory Diseases |
| title_full_unstemmed | Carotenoids from Starfish <i>Patiria pectinifera</i>: Therapeutic Activity in Models of Inflammatory Diseases |
| title_short | Carotenoids from Starfish <i>Patiria pectinifera</i>: Therapeutic Activity in Models of Inflammatory Diseases |
| title_sort | carotenoids from starfish i patiria pectinifera i therapeutic activity in models of inflammatory diseases |
| topic | carotenoids mixture (MC) starfish <i>Patiria pectinifera</i> astaxanthin therapeutic activity inflammatory diseases |
| url | https://www.mdpi.com/1660-3397/21/9/470 |
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