Possible Correlation of Transfusion Transmitted Diseases with Rh type and ABO Blood Group System
Background: Screening of blood is mandatory for transfusion transmitted diseases and is routinely done in the blood banks. As blood is the major source transmission of hepatitis B, hepatitis C, human immunodeficiency virus & many other diseases the hazards can be minimised by effective donor...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3360/27-%206002_E(C)_F(T)_PF1(PRP)_PFA(NC).pdf |
| Summary: | Background: Screening of blood is mandatory for transfusion
transmitted diseases and is routinely done in the blood banks. As
blood is the major source transmission of hepatitis B, hepatitis
C, human immunodeficiency virus & many other diseases the
hazards can be minimised by effective donor selection and
screening.
Aim: To find out the correlation between the transfusion
transmitted diseases and blood groups and the seroprevalence
of HIV, HBV, HCV & syphilis among the apparently healthy human
blood donors.
Study, Setting & Design: This retrospective study was conducted
at the blood bank of a tertiary health care teaching centre for a
period of four years.
Material and Methods: All voluntary and replacement donors
reporting to the blood bank were screened for HIV-1 & 2, HBsAg,
HCV and Syphilis. Anti–HIV -1 & 2, HBsAg & anti - HCV was
tested using the appropriate Enzyme–linked immunosorbent
assay (ELISA) technique using micro–elisa kit supplied by J.Mitra
& Co.Ltd. The seropositive samples were again tested on ELISA
kits of RFCL &/or BIORAD for further confirmation & ruling out any
false positive or false negative results. The rapid plasma reagain
(RPR) test was used for estimation of syphilis infection.
Statistical Analysis: The data entry was carried out using
Microsoft office excel worksheet and was analysed by percentage
and comparison.
Results: Total of 6000 donors were screened which included
voluntary and replacement donors. Seroprevalence of HIV
(0.1833 %), HCV (1.28%), HBsAg (1.5833 %) and syphilis (0.4333
%) was detected. In the study done it was also noted - that the
NEGATIVE blood groups were more prone to TTIs. Blood group
A negative was more prone to TTIs with HIV, HBsAg and VDRL
while blood group B negative was more affected by HCV.
Conclusion: Seroprevalence of these infections shows that
routine screening is a must for blood and blood product safe
transfusion.
Do negative blood groups predispose to TTIs? A finding which
makes us think…. |
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| ISSN: | 2249-782X 0973-709X |