The Myth of The Annular Lipids
In the early 1970s, the existence of a “lipid annulus” stably surrounding the individual intrinsic protein molecules was proposed by several authors. They referred to a number of lipid molecules in slow exchange with the bulk lipid in the bilayer, i.e., more or less protein-bound, and more ordered t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/11/2672 |
| _version_ | 1797469077022703616 |
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| author | Juan C. Gómez-Fernández Félix M. Goñi |
| author_facet | Juan C. Gómez-Fernández Félix M. Goñi |
| author_sort | Juan C. Gómez-Fernández |
| collection | DOAJ |
| description | In the early 1970s, the existence of a “lipid annulus” stably surrounding the individual intrinsic protein molecules was proposed by several authors. They referred to a number of lipid molecules in slow exchange with the bulk lipid in the bilayer, i.e., more or less protein-bound, and more ordered than the bulk lipid. The annular lipids would control enzyme activity. This idea was uncritically accepted by most scientists working with intrinsic membrane proteins at the time, so that the idea operated like a myth in the field. However, in the following decade, hard spectroscopic and biochemical evidence showed that the proposed annular lipids were not immobilized for a sufficiently long time to influence enzyme or transporter activity, nor were they ordered by the protein. Surprisingly, forty years later, the myth survives, and the term ‘annular lipid’ is still in use, in a different, but even more illogical sense. |
| first_indexed | 2024-03-09T19:15:20Z |
| format | Article |
| id | doaj.art-990a8eee310643eb9c4730b2b30a944b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T19:15:20Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-990a8eee310643eb9c4730b2b30a944b2023-11-24T03:48:51ZengMDPI AGBiomedicines2227-90592022-10-011011267210.3390/biomedicines10112672The Myth of The Annular LipidsJuan C. Gómez-Fernández0Félix M. Goñi1Department of Biochemistry and Molecular Biology (A), Faculty of Veterinary Science, Universidad de Murcia, 30100 Murcia, SpainInstituto Biofisika (CSIC, UPV/EHU), Department of Biochemistry, University of the Basque Country, 48940 Leioa, SpainIn the early 1970s, the existence of a “lipid annulus” stably surrounding the individual intrinsic protein molecules was proposed by several authors. They referred to a number of lipid molecules in slow exchange with the bulk lipid in the bilayer, i.e., more or less protein-bound, and more ordered than the bulk lipid. The annular lipids would control enzyme activity. This idea was uncritically accepted by most scientists working with intrinsic membrane proteins at the time, so that the idea operated like a myth in the field. However, in the following decade, hard spectroscopic and biochemical evidence showed that the proposed annular lipids were not immobilized for a sufficiently long time to influence enzyme or transporter activity, nor were they ordered by the protein. Surprisingly, forty years later, the myth survives, and the term ‘annular lipid’ is still in use, in a different, but even more illogical sense.https://www.mdpi.com/2227-9059/10/11/2672lipid annulusannular lipidboundary lipidintrinsic membrane proteinslipid-protein interactionsresonance spectroscopies |
| spellingShingle | Juan C. Gómez-Fernández Félix M. Goñi The Myth of The Annular Lipids Biomedicines lipid annulus annular lipid boundary lipid intrinsic membrane proteins lipid-protein interactions resonance spectroscopies |
| title | The Myth of The Annular Lipids |
| title_full | The Myth of The Annular Lipids |
| title_fullStr | The Myth of The Annular Lipids |
| title_full_unstemmed | The Myth of The Annular Lipids |
| title_short | The Myth of The Annular Lipids |
| title_sort | myth of the annular lipids |
| topic | lipid annulus annular lipid boundary lipid intrinsic membrane proteins lipid-protein interactions resonance spectroscopies |
| url | https://www.mdpi.com/2227-9059/10/11/2672 |
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