MUCOLYTIC ACTIVITY OF ROSELLE (Hibiscus sabdariffa L.) CALYCES EXTRACT ON COW INTESTINAL MUCUS
This study aimed to examine the mucolytic activity of roselle calyces extract on cow intestinal mucus in vitro. The extraction of roselle calyces was performed by the subsequence maceration method using different polarity solvent (n-hexane, ethyl acetate, and methanol). Mucolytic activity of each ex...
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| Format: | Article |
| Language: | Indonesian |
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Syiah Kuala University
2018-10-01
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| Series: | Jurnal Kedokteran Hewan |
| Subjects: | |
| Online Access: | https://jurnal.usk.ac.id/JKH/article/view/9621 |
| _version_ | 1797279002570784768 |
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| author | Nerdy Nerdy Kesaktian Manurung |
| author_facet | Nerdy Nerdy Kesaktian Manurung |
| author_sort | Nerdy Nerdy |
| collection | DOAJ |
| description | This study aimed to examine the mucolytic activity of roselle calyces extract on cow intestinal mucus in vitro. The extraction of roselle
calyces was performed by the subsequence maceration method using different polarity solvent (n-hexane, ethyl acetate, and methanol). Mucolytic
activity of each extract was evaluated by measuring the viscosity of mixture of cow intestinal mucus and phosphate buffer pH 7 compared to
acetylcysteine as the standard mucolytic drug. The result showed that the decreasing of cow intestinal mucus and phosphate buffer pH 7 mixtures
viscosity was indicated the increasing of mucolytic activity. The n-hexane, ethyl acetate, and methanol extract of roselle calyces exhibit dosedependent
mucolytic activity. Mucolytic activity of roselle calyces ethyl acetate extract with dose of 0.8% and roselle calyces methanol extract
with dose of 0.6% showed no significant difference to mucolytic activity from acetylcysteine with dose of 0.1% (positive control). An increased
dose of roselle calyces extract will decrease the viscosity of cow intestinal mucus and phosphate buffer pH 7 mixtures, indicating an increase in
mucolytic activity. |
| first_indexed | 2024-03-07T16:17:06Z |
| format | Article |
| id | doaj.art-990ae0c726ff4d9ba72f0ecdb1733060 |
| institution | Directory Open Access Journal |
| issn | 1978-225X 2502-5600 |
| language | Indonesian |
| last_indexed | 2024-03-07T16:17:06Z |
| publishDate | 2018-10-01 |
| publisher | Syiah Kuala University |
| record_format | Article |
| series | Jurnal Kedokteran Hewan |
| spelling | doaj.art-990ae0c726ff4d9ba72f0ecdb17330602024-03-04T10:29:00ZindSyiah Kuala UniversityJurnal Kedokteran Hewan1978-225X2502-56002018-10-0112210.21157/j.ked.hewan.v12i2.96218894MUCOLYTIC ACTIVITY OF ROSELLE (Hibiscus sabdariffa L.) CALYCES EXTRACT ON COW INTESTINAL MUCUSNerdy Nerdy0Kesaktian Manurung1Department of Pharmacy, Academy of Pharmacy Yayasan Tenaga Pembangunan Arjuna, Toba Samosir, Sumatera Utara, IndonesiaDepartment of Pharmacy, Faculty of Pharmacy and Health Sciences, University of Sari Mutiara Indonesia, Medan, SumateraThis study aimed to examine the mucolytic activity of roselle calyces extract on cow intestinal mucus in vitro. The extraction of roselle calyces was performed by the subsequence maceration method using different polarity solvent (n-hexane, ethyl acetate, and methanol). Mucolytic activity of each extract was evaluated by measuring the viscosity of mixture of cow intestinal mucus and phosphate buffer pH 7 compared to acetylcysteine as the standard mucolytic drug. The result showed that the decreasing of cow intestinal mucus and phosphate buffer pH 7 mixtures viscosity was indicated the increasing of mucolytic activity. The n-hexane, ethyl acetate, and methanol extract of roselle calyces exhibit dosedependent mucolytic activity. Mucolytic activity of roselle calyces ethyl acetate extract with dose of 0.8% and roselle calyces methanol extract with dose of 0.6% showed no significant difference to mucolytic activity from acetylcysteine with dose of 0.1% (positive control). An increased dose of roselle calyces extract will decrease the viscosity of cow intestinal mucus and phosphate buffer pH 7 mixtures, indicating an increase in mucolytic activity.https://jurnal.usk.ac.id/JKH/article/view/9621cow intestinalmucolyticroselle calycesmucusviscosity |
| spellingShingle | Nerdy Nerdy Kesaktian Manurung MUCOLYTIC ACTIVITY OF ROSELLE (Hibiscus sabdariffa L.) CALYCES EXTRACT ON COW INTESTINAL MUCUS Jurnal Kedokteran Hewan cow intestinal mucolytic roselle calyces mucus viscosity |
| title | MUCOLYTIC ACTIVITY OF ROSELLE (Hibiscus sabdariffa L.) CALYCES EXTRACT ON COW INTESTINAL MUCUS |
| title_full | MUCOLYTIC ACTIVITY OF ROSELLE (Hibiscus sabdariffa L.) CALYCES EXTRACT ON COW INTESTINAL MUCUS |
| title_fullStr | MUCOLYTIC ACTIVITY OF ROSELLE (Hibiscus sabdariffa L.) CALYCES EXTRACT ON COW INTESTINAL MUCUS |
| title_full_unstemmed | MUCOLYTIC ACTIVITY OF ROSELLE (Hibiscus sabdariffa L.) CALYCES EXTRACT ON COW INTESTINAL MUCUS |
| title_short | MUCOLYTIC ACTIVITY OF ROSELLE (Hibiscus sabdariffa L.) CALYCES EXTRACT ON COW INTESTINAL MUCUS |
| title_sort | mucolytic activity of roselle hibiscus sabdariffa l calyces extract on cow intestinal mucus |
| topic | cow intestinal mucolytic roselle calyces mucus viscosity |
| url | https://jurnal.usk.ac.id/JKH/article/view/9621 |
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