Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy.

Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy.

Despite the critical role of Epidermal Growth Factor Receptor (EGFR) in glioblastoma pathogenesis, EGFR targeted therapies have achieved limited clinical efficacy. Here we propose an alternate therapeutic strategy based on the conceptual framework of non-oncogene addiction. A directed RNAi screen re...

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Bibliographic Details
Main Authors: Masayuki Nitta, David Kozono, Richard Kennedy, Jayne Stommel, Kimberly Ng, Pascal O Zinn, Deepa Kushwaha, Santosh Kesari, Maria-del-Mar Inda, Jill Wykosky, Frank Furnari, Katherine A Hoadley, Lynda Chin, Ronald A DePinho, Webster K Cavenee, Alan D'Andrea, Clark C Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2879424?pdf=render

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