Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human Pathogens
Recently, the design of new biological metal-ligand complexes has gained a special interest all over the world. In this research, new series of mixed ligand complexes from meloxicam (H<sub>2</sub>mel) and glycine (Gly) were synthesized. Structures of the compounds were investigated emplo...
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MDPI AG
2021-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/5/1480 |
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| author | Hazem S. Elshafie Sadeek A. Sadeek Wael A. Zordok Amira A. Mohamed |
| author_facet | Hazem S. Elshafie Sadeek A. Sadeek Wael A. Zordok Amira A. Mohamed |
| author_sort | Hazem S. Elshafie |
| collection | DOAJ |
| description | Recently, the design of new biological metal-ligand complexes has gained a special interest all over the world. In this research, new series of mixed ligand complexes from meloxicam (H<sub>2</sub>mel) and glycine (Gly) were synthesized. Structures of the compounds were investigated employing elemental analyses, infrared, electronic absorption, <sup>1</sup>H NMR, thermal analyses, effective magnetic moment and conductivity. The estimated molar conductivity of the compounds in 1 × 10<sup>−3</sup> M DMF solution indicates the non-electrolyte existence of the examined complexes. Additionally, the effective magnetic moment values refer to the complexes found as octahedral molecular geometry. The data of the infrared spectra showed the chelation of H<sub>2</sub>mel and Gly with metal ions from amide oxygen and nitrogen of the thyizol groups of H<sub>2</sub>mel and through nitrogen of the amide group and oxygen of the carboxylic group for Gly. Thermal analyses indicated that the new complexes have good thermal stability and initially lose hydration water molecules followed by coordinated water molecules, Gly and H<sub>2</sub>mel. The kinetic parameters were calculated graphically using Coats–Redfern and Horowitz–Metzeger methods at <i>n</i> = 1 and <i>n</i> ≠ 1. The density functional theory (DFT) calculations were performed at B3LYP levels. The optimized geometry of the ligand and its complexes were obtained based on the optimized structures. The data indicated that the complexes are soft with η value in the range 0.114 to 0.086, while η = 0.140 for free H<sub>2</sub>mel. The new prepared complexes were investigated as antibacterial and antifungal agents against some phyto- and human pathogens and the minimum inhibitory concentration (MIC) data showed that complex (<b>A</b>) has the lowest MIC for <i>Listeria</i> and <i>E. coli</i> (10.8 µg/mL). |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T13:25:20Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-990e88fb1de049de86ebe2f4e6f9c3f22023-11-21T09:42:43ZengMDPI AGMolecules1420-30492021-03-01265148010.3390/molecules26051480Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human PathogensHazem S. Elshafie0Sadeek A. Sadeek1Wael A. Zordok2Amira A. Mohamed3School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, ItalyDepartment of Chemistry, Faculty of Science, Zagazig University, 44519 Zagazig, EgyptDepartment of Chemistry, Faculty of Science, Zagazig University, 44519 Zagazig, EgyptDepartment of Basic Science, Zagazig Higher Institute of Engineering and Technology, 445519 Zagazig, EgyptRecently, the design of new biological metal-ligand complexes has gained a special interest all over the world. In this research, new series of mixed ligand complexes from meloxicam (H<sub>2</sub>mel) and glycine (Gly) were synthesized. Structures of the compounds were investigated employing elemental analyses, infrared, electronic absorption, <sup>1</sup>H NMR, thermal analyses, effective magnetic moment and conductivity. The estimated molar conductivity of the compounds in 1 × 10<sup>−3</sup> M DMF solution indicates the non-electrolyte existence of the examined complexes. Additionally, the effective magnetic moment values refer to the complexes found as octahedral molecular geometry. The data of the infrared spectra showed the chelation of H<sub>2</sub>mel and Gly with metal ions from amide oxygen and nitrogen of the thyizol groups of H<sub>2</sub>mel and through nitrogen of the amide group and oxygen of the carboxylic group for Gly. Thermal analyses indicated that the new complexes have good thermal stability and initially lose hydration water molecules followed by coordinated water molecules, Gly and H<sub>2</sub>mel. The kinetic parameters were calculated graphically using Coats–Redfern and Horowitz–Metzeger methods at <i>n</i> = 1 and <i>n</i> ≠ 1. The density functional theory (DFT) calculations were performed at B3LYP levels. The optimized geometry of the ligand and its complexes were obtained based on the optimized structures. The data indicated that the complexes are soft with η value in the range 0.114 to 0.086, while η = 0.140 for free H<sub>2</sub>mel. The new prepared complexes were investigated as antibacterial and antifungal agents against some phyto- and human pathogens and the minimum inhibitory concentration (MIC) data showed that complex (<b>A</b>) has the lowest MIC for <i>Listeria</i> and <i>E. coli</i> (10.8 µg/mL).https://www.mdpi.com/1420-3049/26/5/1480chelation theorytransition metalsthermal analysisantimicrobial activity |
| spellingShingle | Hazem S. Elshafie Sadeek A. Sadeek Wael A. Zordok Amira A. Mohamed Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human Pathogens Molecules chelation theory transition metals thermal analysis antimicrobial activity |
| title | Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human Pathogens |
| title_full | Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human Pathogens |
| title_fullStr | Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human Pathogens |
| title_full_unstemmed | Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human Pathogens |
| title_short | Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human Pathogens |
| title_sort | meloxicam and study of their antimicrobial effects against phyto and human pathogens |
| topic | chelation theory transition metals thermal analysis antimicrobial activity |
| url | https://www.mdpi.com/1420-3049/26/5/1480 |
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