Importance of the hounsfield unit value measured by computed tomography in the differentiation of hydronephrosis and pyonephrosis
Abstract Background Acute or chronic obstruction of the urinary tract can be due to a lot of different causes. Patients with pyonephrosis usually complain of a triad of fever, loin pain and elevated white blood cell count in cases of acute obstruction; and they may also have hypotension in severe ca...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-05-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
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| Online Access: | https://doi.org/10.1186/s43055-022-00799-9 |
| _version_ | 1811324506085523456 |
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| author | Nadine R. Barsoum Aya A. Khodair Samer S. Morsy Sally Y. Shokralla |
| author_facet | Nadine R. Barsoum Aya A. Khodair Samer S. Morsy Sally Y. Shokralla |
| author_sort | Nadine R. Barsoum |
| collection | DOAJ |
| description | Abstract Background Acute or chronic obstruction of the urinary tract can be due to a lot of different causes. Patients with pyonephrosis usually complain of a triad of fever, loin pain and elevated white blood cell count in cases of acute obstruction; and they may also have hypotension in severe cases of the disease. These patients have to be treated with appropriate decompression, or they may develop septic shock. The urgency of the need for treatment greatly depends on the differentiation between hydronephrosis and pyonephrosis. There is a lack of reliable clinical prognosticators of pyonephrosis in patients with obstructive hydronephrosis. Hounsfield unit (HU) measurement is considered as an adequate predictor of pyonephrosis and may aid in the diagnosis and management of this disease that may be fatal. The use of HU values in differentiation between pyonephrosis from hydronephrosis depends on the fact that the pyonephrotic fluid contains infected material, urine, cellular particles and microorganisms, which when combined can increase the HU values on a computed tomography (CT) study. This study was done to assess the diagnostic value of the HU measured CT in differentiation between hydronephrosis and pyonephrosis. Results Thirty-nine patients were included in this study. All patients had loin pain and were diagnosed with pelvicalyceal dilatation by ultrasonographic examination. They then underwent non-contrast CT examination. Using CT scan, the degree of PC dilatation was significantly higher among hydronephrosis group as hydronephrosis group had 63.1% severe dilatation of PCs versus 30.8% in pyonephrosis group with p value 0.0001. Pelvic wall thickness > 2 mm was reported in 10 (76.9%) patients of pyonephrosis group versus in three (7.9%) patients among hydronephrosis group with p value 0.0001. The mean Hounsfield units were significantly higher among pyonephrosis group compared to hydronephrosis group (16 ± 5.2 versus 1.7 ± 5.5) with p value 0.0001. Sensitivity analysis showed that Hounsfield units can significantly diagnose pyonephrosis using the cutoff point 6.2 units, with sensitivity 92.3%, specificity 93.3%, area under the curve (AUC) 96.9% and p value 0.0001. Conclusions Measuring HU in a NCECT scan of the kidney might be helpful for differentiating between hydronephrosis and pyonephrosis especially upon considering 6.2 HU as a cutoff point. |
| first_indexed | 2024-04-13T14:15:33Z |
| format | Article |
| id | doaj.art-991097a5a77d42ef91121ce1dad0ad0e |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-04-13T14:15:33Z |
| publishDate | 2022-05-01 |
| publisher | SpringerOpen |
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| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-991097a5a77d42ef91121ce1dad0ad0e2022-12-22T02:43:39ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622022-05-015311810.1186/s43055-022-00799-9Importance of the hounsfield unit value measured by computed tomography in the differentiation of hydronephrosis and pyonephrosisNadine R. Barsoum0Aya A. Khodair1Samer S. Morsy2Sally Y. Shokralla3Radiology Department, Faculty of Medicine, Cairo UniversityRadiology Department, Faculty of Medicine, Cairo UniversityRadiology Department, Faculty of Medicine, Cairo UniversityRadiology Department, Faculty of Medicine, Cairo UniversityAbstract Background Acute or chronic obstruction of the urinary tract can be due to a lot of different causes. Patients with pyonephrosis usually complain of a triad of fever, loin pain and elevated white blood cell count in cases of acute obstruction; and they may also have hypotension in severe cases of the disease. These patients have to be treated with appropriate decompression, or they may develop septic shock. The urgency of the need for treatment greatly depends on the differentiation between hydronephrosis and pyonephrosis. There is a lack of reliable clinical prognosticators of pyonephrosis in patients with obstructive hydronephrosis. Hounsfield unit (HU) measurement is considered as an adequate predictor of pyonephrosis and may aid in the diagnosis and management of this disease that may be fatal. The use of HU values in differentiation between pyonephrosis from hydronephrosis depends on the fact that the pyonephrotic fluid contains infected material, urine, cellular particles and microorganisms, which when combined can increase the HU values on a computed tomography (CT) study. This study was done to assess the diagnostic value of the HU measured CT in differentiation between hydronephrosis and pyonephrosis. Results Thirty-nine patients were included in this study. All patients had loin pain and were diagnosed with pelvicalyceal dilatation by ultrasonographic examination. They then underwent non-contrast CT examination. Using CT scan, the degree of PC dilatation was significantly higher among hydronephrosis group as hydronephrosis group had 63.1% severe dilatation of PCs versus 30.8% in pyonephrosis group with p value 0.0001. Pelvic wall thickness > 2 mm was reported in 10 (76.9%) patients of pyonephrosis group versus in three (7.9%) patients among hydronephrosis group with p value 0.0001. The mean Hounsfield units were significantly higher among pyonephrosis group compared to hydronephrosis group (16 ± 5.2 versus 1.7 ± 5.5) with p value 0.0001. Sensitivity analysis showed that Hounsfield units can significantly diagnose pyonephrosis using the cutoff point 6.2 units, with sensitivity 92.3%, specificity 93.3%, area under the curve (AUC) 96.9% and p value 0.0001. Conclusions Measuring HU in a NCECT scan of the kidney might be helpful for differentiating between hydronephrosis and pyonephrosis especially upon considering 6.2 HU as a cutoff point.https://doi.org/10.1186/s43055-022-00799-9PyonephrosisHydronephrosisHounsfield unitCT scanCT attenuationObstructive uropathy |
| spellingShingle | Nadine R. Barsoum Aya A. Khodair Samer S. Morsy Sally Y. Shokralla Importance of the hounsfield unit value measured by computed tomography in the differentiation of hydronephrosis and pyonephrosis The Egyptian Journal of Radiology and Nuclear Medicine Pyonephrosis Hydronephrosis Hounsfield unit CT scan CT attenuation Obstructive uropathy |
| title | Importance of the hounsfield unit value measured by computed tomography in the differentiation of hydronephrosis and pyonephrosis |
| title_full | Importance of the hounsfield unit value measured by computed tomography in the differentiation of hydronephrosis and pyonephrosis |
| title_fullStr | Importance of the hounsfield unit value measured by computed tomography in the differentiation of hydronephrosis and pyonephrosis |
| title_full_unstemmed | Importance of the hounsfield unit value measured by computed tomography in the differentiation of hydronephrosis and pyonephrosis |
| title_short | Importance of the hounsfield unit value measured by computed tomography in the differentiation of hydronephrosis and pyonephrosis |
| title_sort | importance of the hounsfield unit value measured by computed tomography in the differentiation of hydronephrosis and pyonephrosis |
| topic | Pyonephrosis Hydronephrosis Hounsfield unit CT scan CT attenuation Obstructive uropathy |
| url | https://doi.org/10.1186/s43055-022-00799-9 |
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