Early experiments with hypothermic oxygenated machine perfusion of kidney grafts from extended criteria donors
Objective: to evaluate the safety and efficacy of hypothermic oxygenated machine perfusion (HOPE) for kidney grafts obtained from expanded criteria donors (ECD).Materials and methods. From June 2018 to June 2021, 200 surgeries involving kidney transplants from deceased donors were performed at Botki...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2022-04-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/1425 |
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| author | A. V. Shabunin M. G. Minina P. V. Drozdov I. V. Nesterenko D. A. Makeev O. S. Zhuravel L. R. Karapetyan S. A. Astapovich |
| author_facet | A. V. Shabunin M. G. Minina P. V. Drozdov I. V. Nesterenko D. A. Makeev O. S. Zhuravel L. R. Karapetyan S. A. Astapovich |
| author_sort | A. V. Shabunin |
| collection | DOAJ |
| description | Objective: to evaluate the safety and efficacy of hypothermic oxygenated machine perfusion (HOPE) for kidney grafts obtained from expanded criteria donors (ECD).Materials and methods. From June 2018 to June 2021, 200 surgeries involving kidney transplants from deceased donors were performed at Botkin City Clinical Hospital. Of these, 123 were men (61.5%) and 77 were women (38.5%). The mean age was 47.62 ± 11.69 (20–73) years. In 102 cases, kidney grafts were procured from ECD. In 92 recipients (90.2%) of kidney transplants from an expanded criteria donor, static cold storage done according to the standard technique was used to preserve the organ; these patients constituted observation group 1. In 10 recipients (9.8%), hypothermic oxygenated perfusion was used in addition to static cold preservation; these patients formed observation group 2.Results. No 30-day mortality was recorded in both observation groups. The mean static cold storage time in group 1 patients was 612.33 ± 178.88 (133–1180) minutes. Overall incidence of delayed graft function was 26.5% (53/200). Incidence of delayed graft function was 19.3% (19/98) for organs from standard donors using static cold storage and 35.8% (33/92) for ECD organs. Twenty-five patients (12.5%) had postoperative complications. Postoperative complications with delayed graft function were diagnosed in 12 patients, which was 22.6% (12/53), with immediate function in 13 patients, which was 8.8% (13/147). Mean cold storage time in group 2 patients was 319.11 ± 110.24 (311–525) minutes. Mean HOPE time was 202.34 ± 21.48 (150–210) minutes. Delayed graft function was recorded in 1 group 2 patient (10%). No complications, including perfusion-related one, were recorded in this group.Conclusion. The unique technique used at Botkin City Clinical Hospital for HOPE in kidney transplant is safe. It provides a low risk of delayed graft function for ECD kidneys. |
| first_indexed | 2024-04-10T00:50:55Z |
| format | Article |
| id | doaj.art-9911df072b6f41f79bbb63c5e7ccec9f |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2025-03-14T05:31:43Z |
| publishDate | 2022-04-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj.art-9911df072b6f41f79bbb63c5e7ccec9f2025-03-05T14:11:53ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912022-04-0124114315010.15825/1995-1191-2022-1-143-1501075Early experiments with hypothermic oxygenated machine perfusion of kidney grafts from extended criteria donorsA. V. Shabunin0M. G. Minina1P. V. Drozdov2I. V. Nesterenko3D. A. Makeev4O. S. Zhuravel5L. R. Karapetyan6S. A. Astapovich7Botkin City Clinical Hospital;Russian Medical Academy of Postgraduate EducationBotkin City Clinical HospitalBotkin City Clinical HospitalBotkin City Clinical HospitalBotkin City Clinical HospitalRussian Medical Academy of Postgraduate EducationBotkin City Clinical HospitalSechenov UniversityObjective: to evaluate the safety and efficacy of hypothermic oxygenated machine perfusion (HOPE) for kidney grafts obtained from expanded criteria donors (ECD).Materials and methods. From June 2018 to June 2021, 200 surgeries involving kidney transplants from deceased donors were performed at Botkin City Clinical Hospital. Of these, 123 were men (61.5%) and 77 were women (38.5%). The mean age was 47.62 ± 11.69 (20–73) years. In 102 cases, kidney grafts were procured from ECD. In 92 recipients (90.2%) of kidney transplants from an expanded criteria donor, static cold storage done according to the standard technique was used to preserve the organ; these patients constituted observation group 1. In 10 recipients (9.8%), hypothermic oxygenated perfusion was used in addition to static cold preservation; these patients formed observation group 2.Results. No 30-day mortality was recorded in both observation groups. The mean static cold storage time in group 1 patients was 612.33 ± 178.88 (133–1180) minutes. Overall incidence of delayed graft function was 26.5% (53/200). Incidence of delayed graft function was 19.3% (19/98) for organs from standard donors using static cold storage and 35.8% (33/92) for ECD organs. Twenty-five patients (12.5%) had postoperative complications. Postoperative complications with delayed graft function were diagnosed in 12 patients, which was 22.6% (12/53), with immediate function in 13 patients, which was 8.8% (13/147). Mean cold storage time in group 2 patients was 319.11 ± 110.24 (311–525) minutes. Mean HOPE time was 202.34 ± 21.48 (150–210) minutes. Delayed graft function was recorded in 1 group 2 patient (10%). No complications, including perfusion-related one, were recorded in this group.Conclusion. The unique technique used at Botkin City Clinical Hospital for HOPE in kidney transplant is safe. It provides a low risk of delayed graft function for ECD kidneys.https://journal.transpl.ru/vtio/article/view/1425kidney transplantexpanded criteria donorshypothermic oxygenated machine perfusion |
| spellingShingle | A. V. Shabunin M. G. Minina P. V. Drozdov I. V. Nesterenko D. A. Makeev O. S. Zhuravel L. R. Karapetyan S. A. Astapovich Early experiments with hypothermic oxygenated machine perfusion of kidney grafts from extended criteria donors Вестник трансплантологии и искусственных органов kidney transplant expanded criteria donors hypothermic oxygenated machine perfusion |
| title | Early experiments with hypothermic oxygenated machine perfusion of kidney grafts from extended criteria donors |
| title_full | Early experiments with hypothermic oxygenated machine perfusion of kidney grafts from extended criteria donors |
| title_fullStr | Early experiments with hypothermic oxygenated machine perfusion of kidney grafts from extended criteria donors |
| title_full_unstemmed | Early experiments with hypothermic oxygenated machine perfusion of kidney grafts from extended criteria donors |
| title_short | Early experiments with hypothermic oxygenated machine perfusion of kidney grafts from extended criteria donors |
| title_sort | early experiments with hypothermic oxygenated machine perfusion of kidney grafts from extended criteria donors |
| topic | kidney transplant expanded criteria donors hypothermic oxygenated machine perfusion |
| url | https://journal.transpl.ru/vtio/article/view/1425 |
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