Emerging delivery systems based on aqueous two-phase systems: A review
The aqueous two-phase system (ATPS) is an all-aqueous system fabricated from two immiscible aqueous phases. It is spontaneously assembled through physical liquid-liquid phase separation (LLPS) and can create suitable templates like the multicompartment of the intracellular environment. Delicate stru...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383523003301 |
| _version_ | 1797365597158244352 |
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| author | Yaowen Zhang Yankun Luo Jingqi Zhao Wenzhuo Zheng Jun Zhan Huaping Zheng Feng Luo |
| author_facet | Yaowen Zhang Yankun Luo Jingqi Zhao Wenzhuo Zheng Jun Zhan Huaping Zheng Feng Luo |
| author_sort | Yaowen Zhang |
| collection | DOAJ |
| description | The aqueous two-phase system (ATPS) is an all-aqueous system fabricated from two immiscible aqueous phases. It is spontaneously assembled through physical liquid-liquid phase separation (LLPS) and can create suitable templates like the multicompartment of the intracellular environment. Delicate structures containing multiple compartments make it possible to endow materials with advanced functions. Due to the properties of ATPSs, ATPS-based drug delivery systems exhibit excellent biocompatibility, extraordinary loading efficiency, and intelligently controlled content release, which are particularly advantageous for delivering drugs in vivo. Therefore, we will systematically review and evaluate ATPSs as an ideal drug delivery system. Based on the basic mechanisms and influencing factors in forming ATPSs, the transformation of ATPSs into valuable biomaterials is described. Afterward, we concentrate on the most recent cutting-edge research on ATPS-based delivery systems. Finally, the potential for further collaborations between ATPS-based drug-carrying biomaterials and disease diagnosis and treatment is also explored. |
| first_indexed | 2024-03-08T16:51:12Z |
| format | Article |
| id | doaj.art-9913298381774a27aba5ce636e1145fe |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-03-08T16:51:12Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-9913298381774a27aba5ce636e1145fe2024-01-05T04:24:44ZengElsevierActa Pharmaceutica Sinica B2211-38352024-01-01141110132Emerging delivery systems based on aqueous two-phase systems: A reviewYaowen Zhang0Yankun Luo1Jingqi Zhao2Wenzhuo Zheng3Jun Zhan4Huaping Zheng5Feng Luo6State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, ChinaDepartment of Dermatology, Rare Diseases Center, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China; Department of Prosthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, China; Corresponding author.The aqueous two-phase system (ATPS) is an all-aqueous system fabricated from two immiscible aqueous phases. It is spontaneously assembled through physical liquid-liquid phase separation (LLPS) and can create suitable templates like the multicompartment of the intracellular environment. Delicate structures containing multiple compartments make it possible to endow materials with advanced functions. Due to the properties of ATPSs, ATPS-based drug delivery systems exhibit excellent biocompatibility, extraordinary loading efficiency, and intelligently controlled content release, which are particularly advantageous for delivering drugs in vivo. Therefore, we will systematically review and evaluate ATPSs as an ideal drug delivery system. Based on the basic mechanisms and influencing factors in forming ATPSs, the transformation of ATPSs into valuable biomaterials is described. Afterward, we concentrate on the most recent cutting-edge research on ATPS-based delivery systems. Finally, the potential for further collaborations between ATPS-based drug-carrying biomaterials and disease diagnosis and treatment is also explored.http://www.sciencedirect.com/science/article/pii/S2211383523003301Aqueous two-phase systemsDrug delivery systemsBiomaterialsMicrocapsulesMicroparticlesCell therapy |
| spellingShingle | Yaowen Zhang Yankun Luo Jingqi Zhao Wenzhuo Zheng Jun Zhan Huaping Zheng Feng Luo Emerging delivery systems based on aqueous two-phase systems: A review Acta Pharmaceutica Sinica B Aqueous two-phase systems Drug delivery systems Biomaterials Microcapsules Microparticles Cell therapy |
| title | Emerging delivery systems based on aqueous two-phase systems: A review |
| title_full | Emerging delivery systems based on aqueous two-phase systems: A review |
| title_fullStr | Emerging delivery systems based on aqueous two-phase systems: A review |
| title_full_unstemmed | Emerging delivery systems based on aqueous two-phase systems: A review |
| title_short | Emerging delivery systems based on aqueous two-phase systems: A review |
| title_sort | emerging delivery systems based on aqueous two phase systems a review |
| topic | Aqueous two-phase systems Drug delivery systems Biomaterials Microcapsules Microparticles Cell therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2211383523003301 |
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