Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity
Type III secretion systems are used by many Gram-negative bacterial pathogens to inject proteins, known as effectors, into the cytosol of host cells. These virulence factors interfere with a diverse array of host signal transduction pathways and cellular processes. Many effectors have catalytic acti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/3/357 |
| _version_ | 1818257406395678720 |
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| author | Juan Luis Araujo-Garrido Joaquín Bernal-Bayard Francisco Ramos-Morales |
| author_facet | Juan Luis Araujo-Garrido Joaquín Bernal-Bayard Francisco Ramos-Morales |
| author_sort | Juan Luis Araujo-Garrido |
| collection | DOAJ |
| description | Type III secretion systems are used by many Gram-negative bacterial pathogens to inject proteins, known as effectors, into the cytosol of host cells. These virulence factors interfere with a diverse array of host signal transduction pathways and cellular processes. Many effectors have catalytic activities to promote post-translational modifications of host proteins. This review focuses on a family of effectors with glycosyltransferase activity that catalyze addition of <i>N</i>-acetyl-d-glucosamine to specific arginine residues in target proteins, leading to reduced NF-κB pathway activation and impaired host cell death. This family includes NleB from <i>Citrobacter rodentium</i>, NleB1 and NleB2 from enteropathogenic and enterohemorrhagic <i>Escherichia coli</i>, and SseK1, SseK2, and SseK3 from <i>Salmonella enterica</i>. First, we place these effectors in the general framework of the glycosyltransferase superfamily and in the particular context of the role of glycosylation in bacterial pathogenesis. Then, we provide detailed information about currently known members of this family, their role in virulence, and their targets. |
| first_indexed | 2024-12-12T17:43:09Z |
| format | Article |
| id | doaj.art-9913780c6c564f3885dbca9ac56dd557 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-12-12T17:43:09Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-9913780c6c564f3885dbca9ac56dd5572022-12-22T00:17:00ZengMDPI AGMicroorganisms2076-26072020-03-018335710.3390/microorganisms8030357microorganisms8030357Type III Secretion Effectors with Arginine N-Glycosyltransferase ActivityJuan Luis Araujo-Garrido0Joaquín Bernal-Bayard1Francisco Ramos-Morales2Departamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, SpainDepartamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, SpainDepartamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, SpainType III secretion systems are used by many Gram-negative bacterial pathogens to inject proteins, known as effectors, into the cytosol of host cells. These virulence factors interfere with a diverse array of host signal transduction pathways and cellular processes. Many effectors have catalytic activities to promote post-translational modifications of host proteins. This review focuses on a family of effectors with glycosyltransferase activity that catalyze addition of <i>N</i>-acetyl-d-glucosamine to specific arginine residues in target proteins, leading to reduced NF-κB pathway activation and impaired host cell death. This family includes NleB from <i>Citrobacter rodentium</i>, NleB1 and NleB2 from enteropathogenic and enterohemorrhagic <i>Escherichia coli</i>, and SseK1, SseK2, and SseK3 from <i>Salmonella enterica</i>. First, we place these effectors in the general framework of the glycosyltransferase superfamily and in the particular context of the role of glycosylation in bacterial pathogenesis. Then, we provide detailed information about currently known members of this family, their role in virulence, and their targets.https://www.mdpi.com/2076-2607/8/3/357glycosyltransferasestype iii secretioneffectorsnlebssek<i>citrobacter</i><i>escherichia</i><i>salmonella</i>death domains |
| spellingShingle | Juan Luis Araujo-Garrido Joaquín Bernal-Bayard Francisco Ramos-Morales Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity Microorganisms glycosyltransferases type iii secretion effectors nleb ssek <i>citrobacter</i> <i>escherichia</i> <i>salmonella</i> death domains |
| title | Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity |
| title_full | Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity |
| title_fullStr | Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity |
| title_full_unstemmed | Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity |
| title_short | Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity |
| title_sort | type iii secretion effectors with arginine n glycosyltransferase activity |
| topic | glycosyltransferases type iii secretion effectors nleb ssek <i>citrobacter</i> <i>escherichia</i> <i>salmonella</i> death domains |
| url | https://www.mdpi.com/2076-2607/8/3/357 |
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