EOP, a Newly Synthesized Ethyl Pyruvate Derivative, Attenuates the Production of Inflammatory Mediators via p38, ERK and NF-κB Pathways in Lipopolysaccharide-Activated BV-2 Microglial Cells

EOP, a Newly Synthesized Ethyl Pyruvate Derivative, Attenuates the Production of Inflammatory Mediators via p38, ERK and NF-κB Pathways in Lipopolysaccharide-Activated BV-2 Microglial Cells

Microglia-induced neuroinflammation is an important pathological mechanism influencing various neurodegenerative disorders. Excess activation of microglia produces a myriad of proinflammatory mediators that decimate neurons. Hence, therapeutic strategies aimed to suppress the activation of microgli...

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Bibliographic Details
Main Authors: Soon Min, Sandeep Vasant More, Ju-Young Park, Sae-Bom Jeon, Shin Young Park, Eun-Jung Park, Sung-Hwa Yoon, Dong-Kug Choi
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
ethyl pyruvate derivative
lipopolysaccharide
microglia
neuroinflammation
neurodegenerative diseases
primary microglia
Online Access:http://www.mdpi.com/1420-3049/19/12/19361

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