Engineering of Yarrowia lipolytica for terpenoid production
Terpenoids are a group of chemicals of great importance for human health and prosperity. Terpenoids can be used for human and animal nutrition, treating diseases, enhancing agricultural output, biofuels, fragrances, cosmetics, and flavouring. However, due to the rapid depletion of global natural res...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Metabolic Engineering Communications |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214030122000220 |
| _version_ | 1828120777140994048 |
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| author | Jonathan Asmund Arnesen Irina Borodina |
| author_facet | Jonathan Asmund Arnesen Irina Borodina |
| author_sort | Jonathan Asmund Arnesen |
| collection | DOAJ |
| description | Terpenoids are a group of chemicals of great importance for human health and prosperity. Terpenoids can be used for human and animal nutrition, treating diseases, enhancing agricultural output, biofuels, fragrances, cosmetics, and flavouring. However, due to the rapid depletion of global natural resources and manufacturing practices relying on unsustainable petrochemical synthesis, there is a need for economic alternatives to supply the world's demand for these essential chemicals. Microbial biosynthesis offers the means to develop scalable and sustainable bioprocesses for terpenoid production. In particular, the non-conventional yeast Yarrowia lipolytica demonstrates excellent potential as a chassis for terpenoid production due to its amenability to industrial production scale-up, genetic engineering, and high accumulation of terpenoid precursors. This review aims to illustrate the scientific progress in developing Y. lipolytica terpenoid cell factories, focusing on metabolic engineering approaches for strain improvement and cultivation optimization. |
| first_indexed | 2024-04-11T14:11:30Z |
| format | Article |
| id | doaj.art-9915743a1fe641e29961198a0ea02ea3 |
| institution | Directory Open Access Journal |
| issn | 2214-0301 |
| language | English |
| last_indexed | 2024-04-11T14:11:30Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Metabolic Engineering Communications |
| spelling | doaj.art-9915743a1fe641e29961198a0ea02ea32022-12-22T04:19:42ZengElsevierMetabolic Engineering Communications2214-03012022-12-0115e00213Engineering of Yarrowia lipolytica for terpenoid productionJonathan Asmund Arnesen0Irina Borodina1The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kgs. Lyngby, DenmarkCorresponding author.; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kgs. Lyngby, DenmarkTerpenoids are a group of chemicals of great importance for human health and prosperity. Terpenoids can be used for human and animal nutrition, treating diseases, enhancing agricultural output, biofuels, fragrances, cosmetics, and flavouring. However, due to the rapid depletion of global natural resources and manufacturing practices relying on unsustainable petrochemical synthesis, there is a need for economic alternatives to supply the world's demand for these essential chemicals. Microbial biosynthesis offers the means to develop scalable and sustainable bioprocesses for terpenoid production. In particular, the non-conventional yeast Yarrowia lipolytica demonstrates excellent potential as a chassis for terpenoid production due to its amenability to industrial production scale-up, genetic engineering, and high accumulation of terpenoid precursors. This review aims to illustrate the scientific progress in developing Y. lipolytica terpenoid cell factories, focusing on metabolic engineering approaches for strain improvement and cultivation optimization.http://www.sciencedirect.com/science/article/pii/S2214030122000220 |
| spellingShingle | Jonathan Asmund Arnesen Irina Borodina Engineering of Yarrowia lipolytica for terpenoid production Metabolic Engineering Communications |
| title | Engineering of Yarrowia lipolytica for terpenoid production |
| title_full | Engineering of Yarrowia lipolytica for terpenoid production |
| title_fullStr | Engineering of Yarrowia lipolytica for terpenoid production |
| title_full_unstemmed | Engineering of Yarrowia lipolytica for terpenoid production |
| title_short | Engineering of Yarrowia lipolytica for terpenoid production |
| title_sort | engineering of yarrowia lipolytica for terpenoid production |
| url | http://www.sciencedirect.com/science/article/pii/S2214030122000220 |
| work_keys_str_mv | AT jonathanasmundarnesen engineeringofyarrowialipolyticaforterpenoidproduction AT irinaborodina engineeringofyarrowialipolyticaforterpenoidproduction |