Licorice (<i>Glycyrrhiza glabra</i>) Extracts-Suitable Pharmacological Interventions for COVID-19? A Review
Even though vaccination has started against COVID-19, people should continue maintaining personal and social caution as it takes months or years to get everyone vaccinated, and we are not sure how long the vaccine remains efficacious. In order to contribute to the mitigation of COVID-19 symptoms, th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Plants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2223-7747/10/12/2600 |
| _version_ | 1797501386842177536 |
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| author | Joji Abraham Singarayer Florentine |
| author_facet | Joji Abraham Singarayer Florentine |
| author_sort | Joji Abraham |
| collection | DOAJ |
| description | Even though vaccination has started against COVID-19, people should continue maintaining personal and social caution as it takes months or years to get everyone vaccinated, and we are not sure how long the vaccine remains efficacious. In order to contribute to the mitigation of COVID-19 symptoms, the pharmaceutical industry aims to develop antiviral drugs to inhibit the SARS-CoV-2 replication and produce anti-inflammatory medications that will inhibit the acute respiratory distress syndrome (ARDS), which is the primary cause of mortality among the COVID-19 patients. In reference to these tasks, this article considers the properties of a medicinal plant named licorice (<i>Glycyrrhiza glabra</i>), whose phytochemicals have shown both antiviral and anti-inflammatory tendencies through previous studies. All the literature was selected through extensive search in various databases such as google scholar, Scopus, the Web of Science, and PubMed. In addition to the antiviral and anti-inflammatory properties, one of the licorice components has an autophagy-enhancing mechanism that studies have suggested to be necessary for COVID-19 treatment. Based on reviewing relevant professional and historical literature regarding the medicinal properties of licorice, it is suggested that it may be worthwhile to conduct in vitro and in vivo studies, including clinical trials with glycyrrhizic and glycyrrhetinic acids together with other flavonoids found in licorice, as there is the potentiality to provide natural interventions against COVID-19 symptoms. |
| first_indexed | 2024-03-10T03:17:40Z |
| format | Article |
| id | doaj.art-99165aa0f962426aa8612f96fb09e7ff |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T03:17:40Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-99165aa0f962426aa8612f96fb09e7ff2023-11-23T10:10:30ZengMDPI AGPlants2223-77472021-11-011012260010.3390/plants10122600Licorice (<i>Glycyrrhiza glabra</i>) Extracts-Suitable Pharmacological Interventions for COVID-19? A ReviewJoji Abraham0Singarayer Florentine1School of Engineering, Information Technology, and Physical Sciences, Mt Helen Campus, Federation University Australia, Ballarat, VIC 3353, AustraliaCentre for Environmental Management, School of Science, Psychology, and Sport, Mt Helen Campus, Federation University Australia, Ballarat, VIC 3353, AustraliaEven though vaccination has started against COVID-19, people should continue maintaining personal and social caution as it takes months or years to get everyone vaccinated, and we are not sure how long the vaccine remains efficacious. In order to contribute to the mitigation of COVID-19 symptoms, the pharmaceutical industry aims to develop antiviral drugs to inhibit the SARS-CoV-2 replication and produce anti-inflammatory medications that will inhibit the acute respiratory distress syndrome (ARDS), which is the primary cause of mortality among the COVID-19 patients. In reference to these tasks, this article considers the properties of a medicinal plant named licorice (<i>Glycyrrhiza glabra</i>), whose phytochemicals have shown both antiviral and anti-inflammatory tendencies through previous studies. All the literature was selected through extensive search in various databases such as google scholar, Scopus, the Web of Science, and PubMed. In addition to the antiviral and anti-inflammatory properties, one of the licorice components has an autophagy-enhancing mechanism that studies have suggested to be necessary for COVID-19 treatment. Based on reviewing relevant professional and historical literature regarding the medicinal properties of licorice, it is suggested that it may be worthwhile to conduct in vitro and in vivo studies, including clinical trials with glycyrrhizic and glycyrrhetinic acids together with other flavonoids found in licorice, as there is the potentiality to provide natural interventions against COVID-19 symptoms.https://www.mdpi.com/2223-7747/10/12/2600ARDSantiviral druganti-inflammatory drugcoronavirusglycyrrhizic acidglycyrrhetinic acid |
| spellingShingle | Joji Abraham Singarayer Florentine Licorice (<i>Glycyrrhiza glabra</i>) Extracts-Suitable Pharmacological Interventions for COVID-19? A Review Plants ARDS antiviral drug anti-inflammatory drug coronavirus glycyrrhizic acid glycyrrhetinic acid |
| title | Licorice (<i>Glycyrrhiza glabra</i>) Extracts-Suitable Pharmacological Interventions for COVID-19? A Review |
| title_full | Licorice (<i>Glycyrrhiza glabra</i>) Extracts-Suitable Pharmacological Interventions for COVID-19? A Review |
| title_fullStr | Licorice (<i>Glycyrrhiza glabra</i>) Extracts-Suitable Pharmacological Interventions for COVID-19? A Review |
| title_full_unstemmed | Licorice (<i>Glycyrrhiza glabra</i>) Extracts-Suitable Pharmacological Interventions for COVID-19? A Review |
| title_short | Licorice (<i>Glycyrrhiza glabra</i>) Extracts-Suitable Pharmacological Interventions for COVID-19? A Review |
| title_sort | licorice i glycyrrhiza glabra i extracts suitable pharmacological interventions for covid 19 a review |
| topic | ARDS antiviral drug anti-inflammatory drug coronavirus glycyrrhizic acid glycyrrhetinic acid |
| url | https://www.mdpi.com/2223-7747/10/12/2600 |
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