Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats
Abstract.: Generalizations of NMDA-receptor antagonists to the discriminative stimulus effects of κ-opioid receptor agonists in rats were examined. Phencyclidine, MK-801, and ketamine, noncompetitive NMDA-receptor antagonists, generalized to the discriminative stimulus effects of U-50,488H, but not...
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| Format: | Article |
| Language: | English |
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Elsevier
2006-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319345281 |
| _version_ | 1819111967506300928 |
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| author | Tomohisa Mori Mutsuko Nomura Kazumi Yoshizawa Hiroshi Nagase Toshiko Sawaguchi Minoru Narita Tsutomu Suzuki |
| author_facet | Tomohisa Mori Mutsuko Nomura Kazumi Yoshizawa Hiroshi Nagase Toshiko Sawaguchi Minoru Narita Tsutomu Suzuki |
| author_sort | Tomohisa Mori |
| collection | DOAJ |
| description | Abstract.: Generalizations of NMDA-receptor antagonists to the discriminative stimulus effects of κ-opioid receptor agonists in rats were examined. Phencyclidine, MK-801, and ketamine, noncompetitive NMDA-receptor antagonists, generalized to the discriminative stimulus effects of U-50,488H, but not those of TRK-820, whereas (±)-3-(2-carbaxypiperazine-4-yl) propyl-1-phosphonic acid (CPP), a competitive NMDA-receptor antagonist, and ifenprodil, an NR1/NR2B NMDA-receptor antagonist, did not, suggesting that non-competitive NMDA-receptor antagonists possess U-50,488H-like discriminative stimulus effects in rats. Since U-50,488H and phencyclidine both induce aversive effects, our findings indicate that the cue of the discriminative stimulus effects of U-50,488H and non-competitive NMDA-receptor antagonists may be associated with their aversive effects. Keywords:: drug discrimination, κ-opioid receptor agonist, NMDA-receptor antagonist |
| first_indexed | 2024-12-22T04:06:02Z |
| format | Article |
| id | doaj.art-9917bcfb89a84449bbffb2fc0b2ac13c |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-22T04:06:02Z |
| publishDate | 2006-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-9917bcfb89a84449bbffb2fc0b2ac13c2022-12-21T18:39:38ZengElsevierJournal of Pharmacological Sciences1347-86132006-01-011002157161Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in RatsTomohisa Mori0Mutsuko Nomura1Kazumi Yoshizawa2Hiroshi Nagase3Toshiko Sawaguchi4Minoru Narita5Tsutomu Suzuki6Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo 142-8501, Japan; Department of Legal Medicine, Tokyo Women’s Medical University, Shinkuku-ku, Tokyo 162-8666, JapanDepartment of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo 142-8501, JapanBasic Research Laboratories, Toray Industries, Inc., Kamakura, Kanagawa 248-8555, JapanDepartment of Legal Medicine, Tokyo Women’s Medical University, Shinkuku-ku, Tokyo 162-8666, JapanDepartment of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa-ku, Tokyo 142-8501, Japan; Corresponding author. suzuki@hoshi.ac.jpAbstract.: Generalizations of NMDA-receptor antagonists to the discriminative stimulus effects of κ-opioid receptor agonists in rats were examined. Phencyclidine, MK-801, and ketamine, noncompetitive NMDA-receptor antagonists, generalized to the discriminative stimulus effects of U-50,488H, but not those of TRK-820, whereas (±)-3-(2-carbaxypiperazine-4-yl) propyl-1-phosphonic acid (CPP), a competitive NMDA-receptor antagonist, and ifenprodil, an NR1/NR2B NMDA-receptor antagonist, did not, suggesting that non-competitive NMDA-receptor antagonists possess U-50,488H-like discriminative stimulus effects in rats. Since U-50,488H and phencyclidine both induce aversive effects, our findings indicate that the cue of the discriminative stimulus effects of U-50,488H and non-competitive NMDA-receptor antagonists may be associated with their aversive effects. Keywords:: drug discrimination, κ-opioid receptor agonist, NMDA-receptor antagonisthttp://www.sciencedirect.com/science/article/pii/S1347861319345281 |
| spellingShingle | Tomohisa Mori Mutsuko Nomura Kazumi Yoshizawa Hiroshi Nagase Toshiko Sawaguchi Minoru Narita Tsutomu Suzuki Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats Journal of Pharmacological Sciences |
| title | Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats |
| title_full | Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats |
| title_fullStr | Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats |
| title_full_unstemmed | Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats |
| title_short | Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats |
| title_sort | generalization of nmda receptor antagonists to the discriminative stimulus effects of κ opioid receptor agonists u 50 488h but not trk 820 in rats |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319345281 |
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