Integrated analysis of microbiota with bile acids for the phototherapy treatment of neonatal jaundice
Introduction Infant jaundice is a common condition which results from a high concentration of serum bilirubin. Phototherapy is a widely used treatment for bilirubin clearance. We analyzed the effect of phototherapy on intestinal flora and metabolism of newborns. The aim was to assess the benefit of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2021-03-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Integrated-analysis-of-microbiota-with-bile-acids-for-nthe-phototherapy-treatment,134023,0,2.html |
| _version_ | 1797435396551868416 |
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| author | Kun Zhang Sainan Fan Anping Lv Yanan Ma Xiaohui Fang Jinping Zhang |
| author_facet | Kun Zhang Sainan Fan Anping Lv Yanan Ma Xiaohui Fang Jinping Zhang |
| author_sort | Kun Zhang |
| collection | DOAJ |
| description | Introduction
Infant jaundice is a common condition which results from a high concentration of serum bilirubin. Phototherapy is a widely used treatment for bilirubin clearance. We analyzed the effect of phototherapy on intestinal flora and metabolism of newborns. The aim was to assess the benefit of treatment for hyperbilirubinemia with phototherapy.
Material and methods
Fifty-three jaundiced infants hospitalized at our neonatal intensive care unit were treated with phototherapy. Of them, 29 were prescribed antibiotics during the hospitalization. Fecal samples were collected before and 24 h and 48 h after phototherapy. The bacterial species and relative abundance were identified with Macrogene sequencing. The bile acids in feces were identified using liquid chromatography-mass spectroscopy (LC-MS).
Results
Differential microbial species/genera and secondary bile acids were found after phototherapy. There are significant differences in the changes of the microbial species/genera between infants who did not receive antibiotic treatment and those who were given antibiotic treatment. Secondary bile acids were also significantly altered. At the same time, the differential microbial species/genera and the differential secondary bile acids interacted with each other.
Conclusions
This study identified several differential intestinal microbial species and secondary bile acids in fecal samples from infants with jaundice before and after phototherapy. Phototherapy can change the flora and its metabolism and its long-term impact needs further observation. |
| first_indexed | 2024-03-09T10:47:34Z |
| format | Article |
| id | doaj.art-99193cea40b844b4b3420931f85bff35 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:47:34Z |
| publishDate | 2021-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-99193cea40b844b4b3420931f85bff352023-12-01T09:52:59ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512021-03-0119240141010.5114/aoms/134023134023Integrated analysis of microbiota with bile acids for the phototherapy treatment of neonatal jaundiceKun Zhang0Sainan Fan1Anping Lv2Yanan Ma3Xiaohui Fang4Jinping Zhang5Department of Pediatrics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaDepartment of Pediatrics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaDepartment of Pediatrics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaDepartment of Pediatrics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaDepartment of Pediatrics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaDepartment of Pediatrics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaIntroduction Infant jaundice is a common condition which results from a high concentration of serum bilirubin. Phototherapy is a widely used treatment for bilirubin clearance. We analyzed the effect of phototherapy on intestinal flora and metabolism of newborns. The aim was to assess the benefit of treatment for hyperbilirubinemia with phototherapy. Material and methods Fifty-three jaundiced infants hospitalized at our neonatal intensive care unit were treated with phototherapy. Of them, 29 were prescribed antibiotics during the hospitalization. Fecal samples were collected before and 24 h and 48 h after phototherapy. The bacterial species and relative abundance were identified with Macrogene sequencing. The bile acids in feces were identified using liquid chromatography-mass spectroscopy (LC-MS). Results Differential microbial species/genera and secondary bile acids were found after phototherapy. There are significant differences in the changes of the microbial species/genera between infants who did not receive antibiotic treatment and those who were given antibiotic treatment. Secondary bile acids were also significantly altered. At the same time, the differential microbial species/genera and the differential secondary bile acids interacted with each other. Conclusions This study identified several differential intestinal microbial species and secondary bile acids in fecal samples from infants with jaundice before and after phototherapy. Phototherapy can change the flora and its metabolism and its long-term impact needs further observation.https://www.archivesofmedicalscience.com/Integrated-analysis-of-microbiota-with-bile-acids-for-nthe-phototherapy-treatment,134023,0,2.htmlphototherapyneonatal jaundiceintestinal florabile acids |
| spellingShingle | Kun Zhang Sainan Fan Anping Lv Yanan Ma Xiaohui Fang Jinping Zhang Integrated analysis of microbiota with bile acids for the phototherapy treatment of neonatal jaundice Archives of Medical Science phototherapy neonatal jaundice intestinal flora bile acids |
| title | Integrated analysis of microbiota with bile acids for
the phototherapy treatment of neonatal jaundice |
| title_full | Integrated analysis of microbiota with bile acids for
the phototherapy treatment of neonatal jaundice |
| title_fullStr | Integrated analysis of microbiota with bile acids for
the phototherapy treatment of neonatal jaundice |
| title_full_unstemmed | Integrated analysis of microbiota with bile acids for
the phototherapy treatment of neonatal jaundice |
| title_short | Integrated analysis of microbiota with bile acids for
the phototherapy treatment of neonatal jaundice |
| title_sort | integrated analysis of microbiota with bile acids for the phototherapy treatment of neonatal jaundice |
| topic | phototherapy neonatal jaundice intestinal flora bile acids |
| url | https://www.archivesofmedicalscience.com/Integrated-analysis-of-microbiota-with-bile-acids-for-nthe-phototherapy-treatment,134023,0,2.html |
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