Brucellosis in childhood: retrospective evaluation of 37 cases and review of the literature
Introduction: The aim of this study is to evaluate the demographic, clinical and laboratory characteristics and treatment results of pediatric patients followed up with the diagnosis of brucellosis in our clinic.Methods: Patients who were followed up with the diagnosis of brucellosis in Kayseri Trai...
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| Format: | Article |
| Language: | English |
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SERNEV
2022-07-01
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| Series: | Family Practice and Palliative Care |
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| Online Access: | https://dergipark.org.tr/en/download/article-file/2127142 |
| _version_ | 1826989755878866944 |
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| author | Emre Kaan Taylan Çelik |
| author_facet | Emre Kaan Taylan Çelik |
| author_sort | Emre Kaan |
| collection | DOAJ |
| description | Introduction: The aim of this study is to evaluate the demographic, clinical and laboratory characteristics and treatment results of pediatric patients followed up with the diagnosis of brucellosis in our clinic.Methods: Patients who were followed up with the diagnosis of brucellosis in Kayseri Training and Research Hospital, Pediatric Infectious Diseases Clinic between October 2016 and December 2018 were retrospectively analyzed.Results: A total of 37 patients, 26 (70.3%) male, were included in the study. The mean age of the patients whose ages ranged from 1 to 17 years was 9.3±4.3 years. Unpasteurized milk and/or dairy products were consumed in 86.5% of the patients and 48.6% had a family history of brucellosis. Joint pain (75.7%) was the most common presenting complaint. In the laboratory evaluation, 8.1% of the patients had leukopenia, 2.7% had thrombocytopenia and 21.4% had ALT elevation. Doxycycline plus rifampicin (43.2%) was the most commonly preferred treatment regimen. Addition of aminoglycoside to initial therapy in hospitalized patients was statistically higher than in outpatients (81.2% vs. 23.8%) (p=0.001). During the follow-up, relapse developed in a total of 4 (10.8%) patients, 3 of whom were outpatients. There was no statistical relationship between the initial treatment regimen and relapse (p=0.418).Conclusion: In conclusion, brucellosis should be kept in mind in terms of differential diagnosis in patients who present with joint pain in our country and who have cytopenia and/or isolated aminotransferase elevation in their investigations.Keywords: Child, Brucellosis, Relapse |
| first_indexed | 2024-03-08T18:59:06Z |
| format | Article |
| id | doaj.art-991b09a12ee84aeda5526b77dfb648c5 |
| institution | Directory Open Access Journal |
| issn | 2459-1505 |
| language | English |
| last_indexed | 2025-02-18T08:10:28Z |
| publishDate | 2022-07-01 |
| publisher | SERNEV |
| record_format | Article |
| series | Family Practice and Palliative Care |
| spelling | doaj.art-991b09a12ee84aeda5526b77dfb648c52024-11-04T07:54:17ZengSERNEVFamily Practice and Palliative Care2459-15052022-07-0173849110.22391/fppc.1035377544Brucellosis in childhood: retrospective evaluation of 37 cases and review of the literatureEmre Kaan0https://orcid.org/0000-0002-4910-421XTaylan Çelik1https://orcid.org/0000-0002-7568-035XDepartment of Pediatrics, Kayseri City Hospital, KayseriDivision of Pediatric Infectious Disease, Faculty of Medicine, Canakkale Onsekiz Mart University, CanakkaleIntroduction: The aim of this study is to evaluate the demographic, clinical and laboratory characteristics and treatment results of pediatric patients followed up with the diagnosis of brucellosis in our clinic.Methods: Patients who were followed up with the diagnosis of brucellosis in Kayseri Training and Research Hospital, Pediatric Infectious Diseases Clinic between October 2016 and December 2018 were retrospectively analyzed.Results: A total of 37 patients, 26 (70.3%) male, were included in the study. The mean age of the patients whose ages ranged from 1 to 17 years was 9.3±4.3 years. Unpasteurized milk and/or dairy products were consumed in 86.5% of the patients and 48.6% had a family history of brucellosis. Joint pain (75.7%) was the most common presenting complaint. In the laboratory evaluation, 8.1% of the patients had leukopenia, 2.7% had thrombocytopenia and 21.4% had ALT elevation. Doxycycline plus rifampicin (43.2%) was the most commonly preferred treatment regimen. Addition of aminoglycoside to initial therapy in hospitalized patients was statistically higher than in outpatients (81.2% vs. 23.8%) (p=0.001). During the follow-up, relapse developed in a total of 4 (10.8%) patients, 3 of whom were outpatients. There was no statistical relationship between the initial treatment regimen and relapse (p=0.418).Conclusion: In conclusion, brucellosis should be kept in mind in terms of differential diagnosis in patients who present with joint pain in our country and who have cytopenia and/or isolated aminotransferase elevation in their investigations.Keywords: Child, Brucellosis, Relapsehttps://dergipark.org.tr/en/download/article-file/2127142çocukbrusellozlökopenirelapstrombositopenichildbrucellosisleukopeniarelapsethrombocytopenia |
| spellingShingle | Emre Kaan Taylan Çelik Brucellosis in childhood: retrospective evaluation of 37 cases and review of the literature Family Practice and Palliative Care çocuk bruselloz lökopeni relaps trombositopeni child brucellosis leukopenia relapse thrombocytopenia |
| title | Brucellosis in childhood: retrospective evaluation of 37 cases and review of the literature |
| title_full | Brucellosis in childhood: retrospective evaluation of 37 cases and review of the literature |
| title_fullStr | Brucellosis in childhood: retrospective evaluation of 37 cases and review of the literature |
| title_full_unstemmed | Brucellosis in childhood: retrospective evaluation of 37 cases and review of the literature |
| title_short | Brucellosis in childhood: retrospective evaluation of 37 cases and review of the literature |
| title_sort | brucellosis in childhood retrospective evaluation of 37 cases and review of the literature |
| topic | çocuk bruselloz lökopeni relaps trombositopeni child brucellosis leukopenia relapse thrombocytopenia |
| url | https://dergipark.org.tr/en/download/article-file/2127142 |
| work_keys_str_mv | AT emrekaan brucellosisinchildhoodretrospectiveevaluationof37casesandreviewoftheliterature AT taylancelik brucellosisinchildhoodretrospectiveevaluationof37casesandreviewoftheliterature |