Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis
Hirschsprung-associated enterocolitis (HAEC) is a common life-threatening complication of Hirschsprung disease (HSCR). It has been proposed that gut microbiota, which have an essential role in gut-homeostasis, are associated with HAEC. Recent studies demonstrated an increase in alpha diversity of fe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/11/2241 |
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| author | Sireekarn Chantakhow Jiraporn Khorana Kanokkan Tepmalai Nonglak Boonchooduang Nipon Chattipakorn Siriporn C. Chattipakorn |
| author_facet | Sireekarn Chantakhow Jiraporn Khorana Kanokkan Tepmalai Nonglak Boonchooduang Nipon Chattipakorn Siriporn C. Chattipakorn |
| author_sort | Sireekarn Chantakhow |
| collection | DOAJ |
| description | Hirschsprung-associated enterocolitis (HAEC) is a common life-threatening complication of Hirschsprung disease (HSCR). It has been proposed that gut microbiota, which have an essential role in gut-homeostasis, are associated with HAEC. Recent studies demonstrated an increase in alpha diversity of fecal microbiota over time in HSCR mice and a decrease in diversity after surgery. In addition, clinical studies have reported a reduction in bacterial richness in HSCR children after surgery. Some studies revealed a difference in microbiota between the proximal ganglionic and distal aganglionic intestine and found a difference in bacterial character between fecal and colonic specimens. HAEC studies found an increase in <i>Proteobacteria</i>, especially <i>Escherichia</i> and <i>Enterobacteriaceae</i>, with a decrease in <i>Firmicutes</i> and <i>Bifidobacterium</i> in HAEC patients. However, the direction of alpha diversity in HAEC patients is still controversial. The self-comparison of microbiota in treatment periods suggested that probiotics might improve gut dysbiosis and decrease the frequency of enterocolitis, but some reported contradictory findings. This review comprehensively summarizes and discusses key findings from animal and clinical data of the distinct microbiome associated with HCSR and the association of gut dysbiosis with the development of HAEC. This information should be useful in the establishment of novel interventions to improve gut dysbiosis and prevent enterocolitis in HSCR patients. |
| first_indexed | 2024-03-10T05:15:59Z |
| format | Article |
| id | doaj.art-99250e54f29a4260ac1e6346d03f2144 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T05:15:59Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-99250e54f29a4260ac1e6346d03f21442023-11-23T00:28:28ZengMDPI AGMicroorganisms2076-26072021-10-01911224110.3390/microorganisms9112241Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated EnterocolitisSireekarn Chantakhow0Jiraporn Khorana1Kanokkan Tepmalai2Nonglak Boonchooduang3Nipon Chattipakorn4Siriporn C. Chattipakorn5Department of Surgery, Division of Pediatric Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Surgery, Division of Pediatric Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Surgery, Division of Pediatric Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pediatrics, Division of Developmental and Behavioral Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandCardiac Electrophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandCardiac Electrophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandHirschsprung-associated enterocolitis (HAEC) is a common life-threatening complication of Hirschsprung disease (HSCR). It has been proposed that gut microbiota, which have an essential role in gut-homeostasis, are associated with HAEC. Recent studies demonstrated an increase in alpha diversity of fecal microbiota over time in HSCR mice and a decrease in diversity after surgery. In addition, clinical studies have reported a reduction in bacterial richness in HSCR children after surgery. Some studies revealed a difference in microbiota between the proximal ganglionic and distal aganglionic intestine and found a difference in bacterial character between fecal and colonic specimens. HAEC studies found an increase in <i>Proteobacteria</i>, especially <i>Escherichia</i> and <i>Enterobacteriaceae</i>, with a decrease in <i>Firmicutes</i> and <i>Bifidobacterium</i> in HAEC patients. However, the direction of alpha diversity in HAEC patients is still controversial. The self-comparison of microbiota in treatment periods suggested that probiotics might improve gut dysbiosis and decrease the frequency of enterocolitis, but some reported contradictory findings. This review comprehensively summarizes and discusses key findings from animal and clinical data of the distinct microbiome associated with HCSR and the association of gut dysbiosis with the development of HAEC. This information should be useful in the establishment of novel interventions to improve gut dysbiosis and prevent enterocolitis in HSCR patients.https://www.mdpi.com/2076-2607/9/11/2241Hirschsprungaganglionosisenterocolitisgut microbiotamicrobiome |
| spellingShingle | Sireekarn Chantakhow Jiraporn Khorana Kanokkan Tepmalai Nonglak Boonchooduang Nipon Chattipakorn Siriporn C. Chattipakorn Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis Microorganisms Hirschsprung aganglionosis enterocolitis gut microbiota microbiome |
| title | Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis |
| title_full | Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis |
| title_fullStr | Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis |
| title_full_unstemmed | Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis |
| title_short | Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis |
| title_sort | alterations of gut bacteria in hirschsprung disease and hirschsprung associated enterocolitis |
| topic | Hirschsprung aganglionosis enterocolitis gut microbiota microbiome |
| url | https://www.mdpi.com/2076-2607/9/11/2241 |
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