Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery
Abstract Breast-conserving surgery (BCS) is a commonly utilized treatment for early stage breast cancers but has relatively high reexcision rates due to post-surgical identification of positive margins. A fast, specific, sensitive, easy-to-use tool for assessing margins intraoperatively could reduce...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-92644-8 |
| _version_ | 1818845194026483712 |
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| author | Erica E. Mason Eli Mattingly Konstantin Herb Monika Śliwiak Sofia Franconi Clarissa Zimmerman Cooley Priscilla J. Slanetz Lawrence L. Wald |
| author_facet | Erica E. Mason Eli Mattingly Konstantin Herb Monika Śliwiak Sofia Franconi Clarissa Zimmerman Cooley Priscilla J. Slanetz Lawrence L. Wald |
| author_sort | Erica E. Mason |
| collection | DOAJ |
| description | Abstract Breast-conserving surgery (BCS) is a commonly utilized treatment for early stage breast cancers but has relatively high reexcision rates due to post-surgical identification of positive margins. A fast, specific, sensitive, easy-to-use tool for assessing margins intraoperatively could reduce the need for additional surgeries, and while many techniques have been explored, the clinical need is still unmet. We assess the potential of Magnetic Particle Imaging (MPI) for intraoperative margin assessment in BCS, using a passively or actively tumor-targeted iron oxide agent and two hardware devices: a hand-held Magnetic Particle detector for identifying residual tumor in the breast, and a small-bore MPI scanner for quickly imaging the tumor distribution in the excised specimen. Here, we present both hardware systems and demonstrate proof-of-concept detection and imaging of clinically relevant phantoms. |
| first_indexed | 2024-12-19T05:25:47Z |
| format | Article |
| id | doaj.art-9926859ee06740ea8ba82500dae17e65 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T05:25:47Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9926859ee06740ea8ba82500dae17e652022-12-21T20:34:23ZengNature PortfolioScientific Reports2045-23222021-06-0111111610.1038/s41598-021-92644-8Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgeryErica E. Mason0Eli Mattingly1Konstantin Herb2Monika Śliwiak3Sofia Franconi4Clarissa Zimmerman Cooley5Priscilla J. Slanetz6Lawrence L. Wald7Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General HospitalHarvard-MIT Division of Health Sciences and TechnologyDepartment of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General HospitalDepartment of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General HospitalDepartment of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General HospitalDepartment of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General HospitalDepartment of Radiology, Boston University Medical CenterDepartment of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General HospitalAbstract Breast-conserving surgery (BCS) is a commonly utilized treatment for early stage breast cancers but has relatively high reexcision rates due to post-surgical identification of positive margins. A fast, specific, sensitive, easy-to-use tool for assessing margins intraoperatively could reduce the need for additional surgeries, and while many techniques have been explored, the clinical need is still unmet. We assess the potential of Magnetic Particle Imaging (MPI) for intraoperative margin assessment in BCS, using a passively or actively tumor-targeted iron oxide agent and two hardware devices: a hand-held Magnetic Particle detector for identifying residual tumor in the breast, and a small-bore MPI scanner for quickly imaging the tumor distribution in the excised specimen. Here, we present both hardware systems and demonstrate proof-of-concept detection and imaging of clinically relevant phantoms.https://doi.org/10.1038/s41598-021-92644-8 |
| spellingShingle | Erica E. Mason Eli Mattingly Konstantin Herb Monika Śliwiak Sofia Franconi Clarissa Zimmerman Cooley Priscilla J. Slanetz Lawrence L. Wald Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery Scientific Reports |
| title | Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery |
| title_full | Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery |
| title_fullStr | Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery |
| title_full_unstemmed | Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery |
| title_short | Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery |
| title_sort | concept for using magnetic particle imaging for intraoperative margin analysis in breast conserving surgery |
| url | https://doi.org/10.1038/s41598-021-92644-8 |
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