Effects of the administration of Elovl5-dependent fatty acids on a spino-cerebellar ataxia 38 mouse model

Effects of the administration of Elovl5-dependent fatty acids on a spino-cerebellar ataxia 38 mouse model

Abstract Background Spinocerebellar ataxia 38 (SCA38) is a rare autosomal neurological disorder characterized by ataxia and cerebellar atrophy. SCA38 is caused by mutations of ELOVL5 gene. ELOVL5 gene encodes a protein, which elongates long chain polyunsaturated fatty acids (PUFAs). Knockout mice la...

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Bibliographic Details
Main Authors: Ilaria Balbo, Francesca Montarolo, Federica Genovese, Filippo Tempia, Eriola Hoxha
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Behavioral and Brain Functions
Subjects:
Elovl5
Spino-cerebellar ataxia
SCA38
Motor deficits
Polyunsaturated fatty acids
Online Access:https://doi.org/10.1186/s12993-022-00194-4

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