Protective role of folic acid in a biomodel of prenatal alcohol intoxication in Wistar rats
Introduction: ethanol is a teratogenic agent and its excessive consumption represents a major worldwide health problem. Objective: to demonstrate the protective role of folic acid on the Central Nervous System and craniofacial dimensions in a biomodel of prenatal alcohol intoxication in Wistar r...
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| Format: | Article |
| Language: | Spanish |
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ECIMED
2019-02-01
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| Series: | Revista de Ciencias Médicas de Pinar del Río |
| Subjects: | |
| Online Access: | http://www.revcmpinar.sld.cu/index.php/publicaciones/article/view/3772 |
| _version_ | 1818623946040279040 |
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| author | Marcia Leticia Gómez García Elisa Maritza Linares Guerra Ariel Montier Iglesias Odalys Díaz González |
| author_facet | Marcia Leticia Gómez García Elisa Maritza Linares Guerra Ariel Montier Iglesias Odalys Díaz González |
| author_sort | Marcia Leticia Gómez García |
| collection | DOAJ |
| description | Introduction: ethanol is a teratogenic agent and its excessive consumption represents a major worldwide health problem.
Objective: to demonstrate the protective role of folic acid on the Central Nervous System and craniofacial dimensions in a biomodel of prenatal alcohol intoxication in Wistar rats.
Methods: an experimental study with offspring of three groups of pregnant rats: without alcohol intoxication; with 5 ml of 40 % ethanol during gestation and with 5 ml of 40 % ethanol plus 200 µg/day of folic acid. The presence of meningocele, encephalocele and microcephaly was evaluated in the offspring and the craniofacial dimensions were measured. The comparison of proportions for independent samples, the Kruskal-Wallis test and a statistically significant risk association was estimated for an Odds-Ratio confidence interval not containing the unit.
Results: supplementation with folic acid in pregnant rats with alcohol intoxication prevented the onset of encephalocele of the offspring, reduce the microcephaly, diminution of the biparietal diameter and the distance between the eyeballs, however the damage of the Central Nervous System could not completely avoided, and not prevent the reduction of the anteroposterior diameter or the nasal-ear pore distance.
Conclusion: the biomodel demonstrated the toxic effect of ethanol and the protection of folic acid on the Central Nervous System and some craniofacial dimensions of the offspring. A higher dose of folic acid, than the one used in the research, could be recommended to achieve a better protection of the offspring. |
| first_indexed | 2024-12-16T18:49:08Z |
| format | Article |
| id | doaj.art-992aa2c351ba460787601335d1b921ec |
| institution | Directory Open Access Journal |
| issn | 1561-3194 |
| language | Spanish |
| last_indexed | 2024-12-16T18:49:08Z |
| publishDate | 2019-02-01 |
| publisher | ECIMED |
| record_format | Article |
| series | Revista de Ciencias Médicas de Pinar del Río |
| spelling | doaj.art-992aa2c351ba460787601335d1b921ec2022-12-21T22:20:45ZspaECIMEDRevista de Ciencias Médicas de Pinar del Río1561-31942019-02-012322121231731Protective role of folic acid in a biomodel of prenatal alcohol intoxication in Wistar ratsMarcia Leticia Gómez García0Elisa Maritza Linares Guerra1Ariel Montier Iglesias2Odalys Díaz González3Universidad de Ciencias Medicas. Pinar del RíoUniversidad de Pinar del Río, Cuba.. Universidad de Ciencias Médicas de Pinar del Río. Cuba.Universidad de Ciencias Médicas de Pinar del Río. Cuba.Introduction: ethanol is a teratogenic agent and its excessive consumption represents a major worldwide health problem. Objective: to demonstrate the protective role of folic acid on the Central Nervous System and craniofacial dimensions in a biomodel of prenatal alcohol intoxication in Wistar rats. Methods: an experimental study with offspring of three groups of pregnant rats: without alcohol intoxication; with 5 ml of 40 % ethanol during gestation and with 5 ml of 40 % ethanol plus 200 µg/day of folic acid. The presence of meningocele, encephalocele and microcephaly was evaluated in the offspring and the craniofacial dimensions were measured. The comparison of proportions for independent samples, the Kruskal-Wallis test and a statistically significant risk association was estimated for an Odds-Ratio confidence interval not containing the unit. Results: supplementation with folic acid in pregnant rats with alcohol intoxication prevented the onset of encephalocele of the offspring, reduce the microcephaly, diminution of the biparietal diameter and the distance between the eyeballs, however the damage of the Central Nervous System could not completely avoided, and not prevent the reduction of the anteroposterior diameter or the nasal-ear pore distance. Conclusion: the biomodel demonstrated the toxic effect of ethanol and the protection of folic acid on the Central Nervous System and some craniofacial dimensions of the offspring. A higher dose of folic acid, than the one used in the research, could be recommended to achieve a better protection of the offspring.http://www.revcmpinar.sld.cu/index.php/publicaciones/article/view/3772ácido fólicosistema nervioso centraldimensionesanomalías craneofacialesintoxicación alcohólica. |
| spellingShingle | Marcia Leticia Gómez García Elisa Maritza Linares Guerra Ariel Montier Iglesias Odalys Díaz González Protective role of folic acid in a biomodel of prenatal alcohol intoxication in Wistar rats Revista de Ciencias Médicas de Pinar del Río ácido fólico sistema nervioso central dimensiones anomalías craneofaciales intoxicación alcohólica. |
| title | Protective role of folic acid in a biomodel of prenatal alcohol intoxication in Wistar rats |
| title_full | Protective role of folic acid in a biomodel of prenatal alcohol intoxication in Wistar rats |
| title_fullStr | Protective role of folic acid in a biomodel of prenatal alcohol intoxication in Wistar rats |
| title_full_unstemmed | Protective role of folic acid in a biomodel of prenatal alcohol intoxication in Wistar rats |
| title_short | Protective role of folic acid in a biomodel of prenatal alcohol intoxication in Wistar rats |
| title_sort | protective role of folic acid in a biomodel of prenatal alcohol intoxication in wistar rats |
| topic | ácido fólico sistema nervioso central dimensiones anomalías craneofaciales intoxicación alcohólica. |
| url | http://www.revcmpinar.sld.cu/index.php/publicaciones/article/view/3772 |
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