Allosteric inhibition of IgE–FcεRI interactions by simultaneous targeting of IgE F(ab’)2 epitopes

Allosteric inhibition of IgE–FcεRI interactions by simultaneous targeting of IgE F(ab’)2 epitopes

Abstract Immunoglobulin E (IgE) plays pivotal roles in allergic diseases through interaction with a high-affinity receptor (FcεRI). We established that Fab fragments of anti-IgE antibodies (HMK-12 Fab) rapidly dissociate preformed IgE-FcεRI complexes in a temperature-dependent manner and inhibit IgE...

Podrobná bibliografie
Hlavní autoři:	Takao Hirano, Akemi Koyanagi, Hideo Ago, Masaki Yamamoto, Jiro Kitaura, Masataka Kasai, Ko Okumura
Médium:	Článek
Jazyk:	English
Vydáno:	Nature Portfolio 2024-08-01
Edice:	Communications Biology
On-line přístup:	https://doi.org/10.1038/s42003-024-06633-4

Podobné jednotky

Tuning IgE: IgE-Associating Molecules and Their Effects on IgE-Dependent Mast Cell Reactions
Autor: Tomoaki Ando, a další
Vydáno: (2021-07-01)

Identification of contact residues in the IgE binding site of human FcεRIα
Autor: Cook, J, a další
Vydáno: (1997)

Effects of Omalizumab on FcεRI and IgE Expression in Lesional Skin of Bullous Pemphigoid
Autor: S. Morteza Seyed Jafari, a další
Vydáno: (2019-08-01)

Structural basis of the IgE-Fc epsilon RI interaction.
Autor: Beavil, A, a další
Vydáno: (1993)

Structural basis of the IgE-Fc epsilon RI interaction.
Autor: Beavil, A, a další
Vydáno: (1993)

No evidence for IgE receptor FcεRI expression on bronchial epithelial cells of asthmatic patients
Autor: Omer Qibi, a další
Vydáno: (2018-11-01)

Human IgE-FcεRI chip assay to screen natural products for antipruritic activity
Autor: Yong Wan Cho, a další
Vydáno: (2024-06-01)

Hypersensitivity reactions to asparaginase in mice are mediated by anti-asparaginase IgE and IgG and the immunoglobulin receptors FcεRI and FcγRIII
Autor: Sanjay Rathod, a další
Vydáno: (2019-02-01)

Humanized FcεRI Expressed on Mouse Eosinophils Mediates IgE-Facilitated Eosinophil Antigen Presentation
Autor: Haibin Wang, a další
Vydáno: (2025-02-01)

Single-cell measurements of IgE-mediated FcεRI signaling using an integrated microfluidic platform.
Autor: Yanli Liu, a další
Vydáno: (2013-01-01)

IgE glycans promote anti-IgE IgG autoantibodies that facilitate IgE serum clearance via Fc Receptors
Autor: Kevin Plattner, a další
Vydáno: (2022-12-01)

Evaluation of FcεRl-binding serum IgE in patients with ocular allergic diseases
Autor: Satoru Matsumoto, a další
Vydáno: (1999-01-01)

TIRF Microscope Image Sequences of Fluorescent IgE-FcεRI Receptor Complexes inside a FcεRI-Centric Synapse in RBL-2H3 Cells
Autor: Rachel Drawbond, a další
Vydáno: (2019-07-01)

Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction
Autor: Frederic Jabs, a další
Vydáno: (2018-01-01)

Quercetin and Resveratrol Differentially Decrease Expression of the High-Affinity IgE Receptor (FcεRI) by Human and Mouse Mast Cells
Autor: Syed Benazir Alam, a další
Vydáno: (2022-10-01)

Altered MicroRNA Expression Profiles in Activated Mast Cells Following IgE-FcεRI Cross-Linking with Antigen
Autor: Yaoshu Teng, a další
Vydáno: (2015-04-01)

Comparison between Sensitivity of Autologous Skin Serum Test and Autologous Plasma Skin Test in Patients with Chronic Idiopathic Urticaria for Detection of Antibody against IgE or IgE Receptor (FcεRIα)
Autor: Vahid Sajedi, a další
Vydáno: (2011-06-01)

Soluble IgE‐binding factors in the serum of food‐allergic patients: Possible pathophysiological role of soluble FcεRI as protective factor
Autor: Carolin Steinert, a další
Vydáno: (2023-02-01)

The evolution of flexibility and function in the Fc domains of IgM, IgY, and IgE
Autor: Rosaleen A. Calvert, a další
Vydáno: (2024-10-01)

Fc epsilon RI immunoconjugate inhibits IgE-mediated passive cutaneous anaphylaxis (PCA) in the rat
Autor: Holland, K, a další
Vydáno: (1999)

Neuronal FcεRIα directly mediates ocular itch via IgE-immune complex in a mouse model of allergic conjunctivitis
Autor: Huan Cui, a další
Vydáno: (2022-02-01)

Regulation of IgE activity in inhalational tolerance via formation of IgG anti-IgE/IgE immune complexes
Autor: Sonali J. Bracken, a další
Vydáno: (2018-05-01)

Human IgE does not bind to human FcRn
Autor: Maximilian Brinkhaus, a další
Vydáno: (2022-01-01)

IgE-mediated Chronic Allergic Inflammation (IgE-CAI)
Autor: Yasuyo Harada, a další
Vydáno: (2012-10-01)

A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum.
Autor: Eleonora Dehlink, a další
Vydáno: (2011-04-01)

A Co-Expressed Natural Antisense RNA FCER1A-AS Controls IgE-Dependent Immunity by Promoting Expression of FcεRIα
Autor: Ruo-yu Tang, a další
Vydáno: (2023-06-01)

IgE-Related Chronic Diseases and Anti-IgE-Based Treatments
Autor: Arnau Navinés-Ferrer, a další
Vydáno: (2016-01-01)

Self-reactive IgE and anti-IgE therapy in autoimmune diseases
Autor: Anna Olewicz-Gawlik, a další
Vydáno: (2023-01-01)

In silico identification of IgE-binding epitopes of osmotin protein.
Autor: Prerna Sharma, a další
Vydáno: (2013-01-01)

The crystal structure of IgE Fc reveals an asymmetrically bent conformation.
Autor: Wan, T, a další
Vydáno: (2002)

Hydrodynamic studies of a complex between the Fc fragment of human IgE and a soluble fragment of the Fc epsilon RI alpha chain.
Autor: Keown, M, a další
Vydáno: (1995)

Recombinant soluble form of the high-affinity IgE receptor α subunit and anti-IgE antibody inhibit IgE synthesis by IgE-expressing B cells through distinct pathways
Autor: Keiichi Kajiwara, a další
Vydáno: (2002-01-01)

Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population.
Autor: Eleonora Dehlink, a další
Vydáno: (2010-08-01)

Fc-epsilon-RI, the high affinity IgE-receptor, is robustly expressed in the upper gastrointestinal tract and modulated by mucosal inflammation.
Autor: Christina Bannert, a další
Vydáno: (2012-01-01)

Hyper IgE Syndrome
Autor: Poonam Marwah, a další
Vydáno: (2019-03-01)

IgE and IgG4 epitopes of the peanut allergens shift following oral immunotherapy
Autor: Ian M. Rambo, a další
Vydáno: (2023-11-01)

Editorial: IgE mediated and non IgE mediated cow’s milk protein allergy
Autor: Rita Nocerino, a další
Vydáno: (2024-01-01)

The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodelling.
Autor: Michael Roth, a další
Vydáno: (2013-01-01)

Proinflammatory and Th2 cytokines regulate the high affinity IgE receptor (FcepsilonRI) and IgE-dependant activation of human airway smooth muscle cells.
Autor: Naresh Singh Redhu, a další
Vydáno: (2009-07-01)

Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcεRI-aggregation reveals a complex network of genes involved in inflammatory responses
Autor: Chow Kah, a další
Vydáno: (2006-08-01)