Allosteric inhibition of IgE–FcεRI interactions by simultaneous targeting of IgE F(ab’)2 epitopes
Abstract Immunoglobulin E (IgE) plays pivotal roles in allergic diseases through interaction with a high-affinity receptor (FcεRI). We established that Fab fragments of anti-IgE antibodies (HMK-12 Fab) rapidly dissociate preformed IgE-FcεRI complexes in a temperature-dependent manner and inhibit IgE...
| Auteurs principaux: | , , , , , , |
|---|---|
| Format: | Article |
| Langue: | English |
| Publié: |
Nature Portfolio
2024-08-01
|
| Collection: | Communications Biology |
| Accès en ligne: | https://doi.org/10.1038/s42003-024-06633-4 |