Allosteric inhibition of IgE–FcεRI interactions by simultaneous targeting of IgE F(ab’)2 epitopes
Abstract Immunoglobulin E (IgE) plays pivotal roles in allergic diseases through interaction with a high-affinity receptor (FcεRI). We established that Fab fragments of anti-IgE antibodies (HMK-12 Fab) rapidly dissociate preformed IgE-FcεRI complexes in a temperature-dependent manner and inhibit IgE...
| Hauptverfasser: | , , , , , , |
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| Format: | Artikel |
| Sprache: | English |
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Nature Portfolio
2024-08-01
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| Schriftenreihe: | Communications Biology |
| Online Zugang: | https://doi.org/10.1038/s42003-024-06633-4 |