Anti-Quorum Sensing Activity of Probiotics: The Mechanism and Role in Food and Gut Health
Background: Quorum sensing (QS) is a cell-to-cell communication mechanism that occurs between inter- and intra-bacterial species and is regulated by signaling molecules called autoinducers (AIs). It has been suggested that probiotics can exert a QS inhibitory effect through their metabolites. Purpos...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/3/793 |
| _version_ | 1827748486803619840 |
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| author | Mohammed Kamal Salman Jumana Abuqwider Gianluigi Mauriello |
| author_facet | Mohammed Kamal Salman Jumana Abuqwider Gianluigi Mauriello |
| author_sort | Mohammed Kamal Salman |
| collection | DOAJ |
| description | Background: Quorum sensing (QS) is a cell-to-cell communication mechanism that occurs between inter- and intra-bacterial species and is regulated by signaling molecules called autoinducers (AIs). It has been suggested that probiotics can exert a QS inhibitory effect through their metabolites. Purpose: To provide an overview of (1) the anti-QS activity of probiotics and its mechanism against foodborne pathogenic and spoilage bacteria; (2) the potential role of the QS of probiotics in gut health; and (3) the impact of microencapsulation on QS. Results: <i>Lactobacillus</i> species have been extensively studied for their anti-QS activity and have been found to effectively disrupt QS in vitro. However, their effectiveness in a food matrix is yet to be determined as they interfere with the AI receptor or its synthesis. QS plays an important role in both the biofilm formation of probiotics and pathogenic bacteria. Moreover, in vitro and animal studies have shown that QS molecules can modulate cytokine responses and gut dysbiosis and maintain intestinal barrier function. In this scenario, microencapsulation was found to enhance AI activity. However, its impact on the anti-QS activity of probiotics and its underlying mechanism remains unclear. Conclusions: Probiotics are potential candidates to block QS activity in foodborne pathogenic and food spoilage bacteria. Microencapsulation increases QS efficacy. However, more research is still needed for the identification of the QS inhibitory metabolites from probiotics and for the elucidation of the anti-QS mechanism of probiotics (microcapsules and free cells) in food and the human gut. |
| first_indexed | 2024-03-11T06:09:28Z |
| format | Article |
| id | doaj.art-9930f156b6eb41868de7635992015791 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-11T06:09:28Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-9930f156b6eb41868de76359920157912023-11-17T12:46:10ZengMDPI AGMicroorganisms2076-26072023-03-0111379310.3390/microorganisms11030793Anti-Quorum Sensing Activity of Probiotics: The Mechanism and Role in Food and Gut HealthMohammed Kamal Salman0Jumana Abuqwider1Gianluigi Mauriello2Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, ItalyDepartment of Agricultural Sciences, University of Naples Federico II, 80055 Portici, ItalyDepartment of Agricultural Sciences, University of Naples Federico II, 80055 Portici, ItalyBackground: Quorum sensing (QS) is a cell-to-cell communication mechanism that occurs between inter- and intra-bacterial species and is regulated by signaling molecules called autoinducers (AIs). It has been suggested that probiotics can exert a QS inhibitory effect through their metabolites. Purpose: To provide an overview of (1) the anti-QS activity of probiotics and its mechanism against foodborne pathogenic and spoilage bacteria; (2) the potential role of the QS of probiotics in gut health; and (3) the impact of microencapsulation on QS. Results: <i>Lactobacillus</i> species have been extensively studied for their anti-QS activity and have been found to effectively disrupt QS in vitro. However, their effectiveness in a food matrix is yet to be determined as they interfere with the AI receptor or its synthesis. QS plays an important role in both the biofilm formation of probiotics and pathogenic bacteria. Moreover, in vitro and animal studies have shown that QS molecules can modulate cytokine responses and gut dysbiosis and maintain intestinal barrier function. In this scenario, microencapsulation was found to enhance AI activity. However, its impact on the anti-QS activity of probiotics and its underlying mechanism remains unclear. Conclusions: Probiotics are potential candidates to block QS activity in foodborne pathogenic and food spoilage bacteria. Microencapsulation increases QS efficacy. However, more research is still needed for the identification of the QS inhibitory metabolites from probiotics and for the elucidation of the anti-QS mechanism of probiotics (microcapsules and free cells) in food and the human gut.https://www.mdpi.com/2076-2607/11/3/793quorum sensingquorum sensing inhibitionquorum quenchingvirulencebiofilmmicroencapsulation |
| spellingShingle | Mohammed Kamal Salman Jumana Abuqwider Gianluigi Mauriello Anti-Quorum Sensing Activity of Probiotics: The Mechanism and Role in Food and Gut Health Microorganisms quorum sensing quorum sensing inhibition quorum quenching virulence biofilm microencapsulation |
| title | Anti-Quorum Sensing Activity of Probiotics: The Mechanism and Role in Food and Gut Health |
| title_full | Anti-Quorum Sensing Activity of Probiotics: The Mechanism and Role in Food and Gut Health |
| title_fullStr | Anti-Quorum Sensing Activity of Probiotics: The Mechanism and Role in Food and Gut Health |
| title_full_unstemmed | Anti-Quorum Sensing Activity of Probiotics: The Mechanism and Role in Food and Gut Health |
| title_short | Anti-Quorum Sensing Activity of Probiotics: The Mechanism and Role in Food and Gut Health |
| title_sort | anti quorum sensing activity of probiotics the mechanism and role in food and gut health |
| topic | quorum sensing quorum sensing inhibition quorum quenching virulence biofilm microencapsulation |
| url | https://www.mdpi.com/2076-2607/11/3/793 |
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