Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3

Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3

Streptococcus pneumoniae is a major pathogen in children, elderly subjects, and immunodeficient patients. Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule (PRM) involved in resistance to selected microbial agents and in regulation of inflammation. The present study was designed to as...

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Bibliographic Details
Main Authors: Rémi Porte, Rita Silva-Gomes, Charlotte Theroude, Raffaella Parente, Fatemeh Asgari, Marina Sironi, Fabio Pasqualini, Sonia Valentino, Rosanna Asselta, Camilla Recordati, Marta Noemi Monari, Andrea Doni, Antonio Inforzato, Carlos Rodriguez-Gallego, Ignacio Obando, Elena Colino, Barbara Bottazzi, Alberto Mantovani
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-05-01
Series:eLife
Subjects:
Streptococcus pneumoniae
Pentraxin 3
neutrophils
inflammation
P-selectin
endothelial cells
Online Access:https://elifesciences.org/articles/78601

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