Higher dose of erythropoietin for anemia correction in Balkan endemic nephropathy patients
Introduction. Balkan endemic nephropathy (BEN) patients maintained with hemodialysis have more severe anemia than patients with other kidney diseases. Objective. The aim of the study was to compare the improvement of anemia in BEN patients and those with other kidney diseases during treatment wi...
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| Format: | Article |
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Serbian Medical Society
2012-01-01
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| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2012/0370-81791208456L.pdf |
| _version_ | 1819076100159963136 |
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| author | Lukić Ljiljana Mitrović Đorđe Kovačević Sanda Stanišić Momir Pelemiš Snežana Tešić Jelica Vakičić Slaven Đukanović Ljubica |
| author_facet | Lukić Ljiljana Mitrović Đorđe Kovačević Sanda Stanišić Momir Pelemiš Snežana Tešić Jelica Vakičić Slaven Đukanović Ljubica |
| author_sort | Lukić Ljiljana |
| collection | DOAJ |
| description | Introduction. Balkan endemic nephropathy (BEN) patients maintained with hemodialysis have more severe anemia than patients with other kidney diseases. Objective. The aim of the study was to compare the improvement of anemia in BEN patients and those with other kidney diseases during treatment with human recombinant erythropoietin (rHuEpo). Methods. The study involved 240 patients on regular hemodialysis for more than one year. Out of them 146 had BEN and 94 other kidney diseases (21 glomerulonephritis, 20 hypertension, 18 diabetes, 10 policystic kidney disease, 5 obstructive nephropathy, 18 other diseases). Treatment with rHuEpo was carried out according to European guidelines for the management of anemia. Results. Patients with BEN were older and were less frequently treated with ACEi than patients with other kidney diseases. At the onset of the study mean hemoglobin level (109.6±22.3 vs. 112.7±11.3 g/l) was significantly lower, but serum ferritin level and rHuEpo dose (65.4±22.3 vs. 57.5±22.5 U/kg/week) were significantly higher in BEN patients than in others. In prospective four months study these differences in hemoglobin levels and rHuEpo doses maintained. The rate of anemia improvement was examined in 15 BEN patients and 10 patients with other kidney diseases at the beginning of rHuEpo treatment. No difference in the rate of anemia improvement was found between the two groups but higher rHuEpo doses were used in BEN patients. Conclusion. Patients with BEN on regular hemodialysis had more severe anemia and required higher rHuEpo doses for maintaining target hemoglobin level. |
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| format | Article |
| id | doaj.art-99329721e6864206af57995d2ffe2e52 |
| institution | Directory Open Access Journal |
| issn | 0370-8179 |
| language | English |
| last_indexed | 2024-12-21T18:35:56Z |
| publishDate | 2012-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-99329721e6864206af57995d2ffe2e522022-12-21T18:54:08ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792012-01-011407-845646110.2298/SARH1208456LHigher dose of erythropoietin for anemia correction in Balkan endemic nephropathy patientsLukić LjiljanaMitrović ĐorđeKovačević SandaStanišić MomirPelemiš SnežanaTešić JelicaVakičić SlavenĐukanović LjubicaIntroduction. Balkan endemic nephropathy (BEN) patients maintained with hemodialysis have more severe anemia than patients with other kidney diseases. Objective. The aim of the study was to compare the improvement of anemia in BEN patients and those with other kidney diseases during treatment with human recombinant erythropoietin (rHuEpo). Methods. The study involved 240 patients on regular hemodialysis for more than one year. Out of them 146 had BEN and 94 other kidney diseases (21 glomerulonephritis, 20 hypertension, 18 diabetes, 10 policystic kidney disease, 5 obstructive nephropathy, 18 other diseases). Treatment with rHuEpo was carried out according to European guidelines for the management of anemia. Results. Patients with BEN were older and were less frequently treated with ACEi than patients with other kidney diseases. At the onset of the study mean hemoglobin level (109.6±22.3 vs. 112.7±11.3 g/l) was significantly lower, but serum ferritin level and rHuEpo dose (65.4±22.3 vs. 57.5±22.5 U/kg/week) were significantly higher in BEN patients than in others. In prospective four months study these differences in hemoglobin levels and rHuEpo doses maintained. The rate of anemia improvement was examined in 15 BEN patients and 10 patients with other kidney diseases at the beginning of rHuEpo treatment. No difference in the rate of anemia improvement was found between the two groups but higher rHuEpo doses were used in BEN patients. Conclusion. Patients with BEN on regular hemodialysis had more severe anemia and required higher rHuEpo doses for maintaining target hemoglobin level.http://www.doiserbia.nb.rs/img/doi/0370-8179/2012/0370-81791208456L.pdfanemiahuman recombinant erythropoietinBalkan endemic nephropathyhemodialysis |
| spellingShingle | Lukić Ljiljana Mitrović Đorđe Kovačević Sanda Stanišić Momir Pelemiš Snežana Tešić Jelica Vakičić Slaven Đukanović Ljubica Higher dose of erythropoietin for anemia correction in Balkan endemic nephropathy patients Srpski Arhiv za Celokupno Lekarstvo anemia human recombinant erythropoietin Balkan endemic nephropathy hemodialysis |
| title | Higher dose of erythropoietin for anemia correction in Balkan endemic nephropathy patients |
| title_full | Higher dose of erythropoietin for anemia correction in Balkan endemic nephropathy patients |
| title_fullStr | Higher dose of erythropoietin for anemia correction in Balkan endemic nephropathy patients |
| title_full_unstemmed | Higher dose of erythropoietin for anemia correction in Balkan endemic nephropathy patients |
| title_short | Higher dose of erythropoietin for anemia correction in Balkan endemic nephropathy patients |
| title_sort | higher dose of erythropoietin for anemia correction in balkan endemic nephropathy patients |
| topic | anemia human recombinant erythropoietin Balkan endemic nephropathy hemodialysis |
| url | http://www.doiserbia.nb.rs/img/doi/0370-8179/2012/0370-81791208456L.pdf |
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