Strategies for Surface Design in Surface Plasmon Resonance (SPR) Sensing
Surface plasmon resonance (SPR) comprises several surface-sensitive techniques that enable the trace and ultra-trace detection of various analytes through affinity pairing. Although enabling label-free, sensitive detection and real-time monitoring, several issues remain to be addressed, such as poor...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/13/4/465 |
| _version_ | 1797606225878188032 |
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| author | Cristina-Virginia Topor Mihaela Puiu Camelia Bala |
| author_facet | Cristina-Virginia Topor Mihaela Puiu Camelia Bala |
| author_sort | Cristina-Virginia Topor |
| collection | DOAJ |
| description | Surface plasmon resonance (SPR) comprises several surface-sensitive techniques that enable the trace and ultra-trace detection of various analytes through affinity pairing. Although enabling label-free, sensitive detection and real-time monitoring, several issues remain to be addressed, such as poor stability, non-specific adsorption and the loss of operational activity of biomolecules. In this review, the progress over sensor modification, immobilization techniques and novel 2D nanomaterials, gold nanostructures and magnetic nanoparticles for signal amplification is discussed. The advantages and disadvantages of each design strategy will be provided together with some of the recent achievements. |
| first_indexed | 2024-03-11T05:12:11Z |
| format | Article |
| id | doaj.art-9932d32e94784d3a8d0b817220e4bbce |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-11T05:12:11Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-9932d32e94784d3a8d0b817220e4bbce2023-11-17T18:31:04ZengMDPI AGBiosensors2079-63742023-04-0113446510.3390/bios13040465Strategies for Surface Design in Surface Plasmon Resonance (SPR) SensingCristina-Virginia Topor0Mihaela Puiu1Camelia Bala2Department of Analytical and Physical Chemistry, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018 Bucharest, RomaniaDepartment of Analytical and Physical Chemistry, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018 Bucharest, RomaniaDepartment of Analytical and Physical Chemistry, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018 Bucharest, RomaniaSurface plasmon resonance (SPR) comprises several surface-sensitive techniques that enable the trace and ultra-trace detection of various analytes through affinity pairing. Although enabling label-free, sensitive detection and real-time monitoring, several issues remain to be addressed, such as poor stability, non-specific adsorption and the loss of operational activity of biomolecules. In this review, the progress over sensor modification, immobilization techniques and novel 2D nanomaterials, gold nanostructures and magnetic nanoparticles for signal amplification is discussed. The advantages and disadvantages of each design strategy will be provided together with some of the recent achievements.https://www.mdpi.com/2079-6374/13/4/465biosensorsurface plasmon resonanceimmobilizationclick chemistrynanomaterialsmetal organic framework |
| spellingShingle | Cristina-Virginia Topor Mihaela Puiu Camelia Bala Strategies for Surface Design in Surface Plasmon Resonance (SPR) Sensing Biosensors biosensor surface plasmon resonance immobilization click chemistry nanomaterials metal organic framework |
| title | Strategies for Surface Design in Surface Plasmon Resonance (SPR) Sensing |
| title_full | Strategies for Surface Design in Surface Plasmon Resonance (SPR) Sensing |
| title_fullStr | Strategies for Surface Design in Surface Plasmon Resonance (SPR) Sensing |
| title_full_unstemmed | Strategies for Surface Design in Surface Plasmon Resonance (SPR) Sensing |
| title_short | Strategies for Surface Design in Surface Plasmon Resonance (SPR) Sensing |
| title_sort | strategies for surface design in surface plasmon resonance spr sensing |
| topic | biosensor surface plasmon resonance immobilization click chemistry nanomaterials metal organic framework |
| url | https://www.mdpi.com/2079-6374/13/4/465 |
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