The Classification of Suspected Predominant Nociplastic Pain in People with Moderate and Severe Haemophilia: A Secondary Exploratory Study
In people with haemophilia (PwH), joint pain is a major comorbidity that is often overlooked and under-treated. It is believed that, to ensure the most successful outcome, pain management should be tailored to the predominant pain phenotype (i.e., nociceptive, neuropathic and nociplastic). The 2021...
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MDPI AG
2023-09-01
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| Online Access: | https://www.mdpi.com/2227-9059/11/9/2479 |
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| author | Anthe Foubert Nathalie Anne Roussel Valérie-Anne Chantrain Philip Maes Lies Durnez Sébastien Lobet Catherine Lambert Cédric Hermans Mira Meeus |
| author_facet | Anthe Foubert Nathalie Anne Roussel Valérie-Anne Chantrain Philip Maes Lies Durnez Sébastien Lobet Catherine Lambert Cédric Hermans Mira Meeus |
| author_sort | Anthe Foubert |
| collection | DOAJ |
| description | In people with haemophilia (PwH), joint pain is a major comorbidity that is often overlooked and under-treated. It is believed that, to ensure the most successful outcome, pain management should be tailored to the predominant pain phenotype (i.e., nociceptive, neuropathic and nociplastic). The 2021 clinical criteria and grading system for nociplastic pain, established by the International Association for the Study of Pain (IASP), emphasize the necessity of early-stage identification and predominant pain type classification. Consistent with findings in other chronic musculoskeletal pain conditions, studies suggest that a subgroup of PwH suffers from nociplastic pain, i.e., pain arising from altered nociception rather than structural damage, but this has not yet been explored in PwH. This study aimed to identify PwH with “unlikely”, “possible” and “probable” nociplastic pain and investigate differences in anthropometric, demographic and clinical characteristics and psychological factors between subgroups of PwH and healthy individuals.: The IASP clinical criteria and grading system were used to classify pain types in adult men with moderate or severe haemophilia recruited from two Belgian haemophilia treatment centres. Statistical analyses were applied to study between-subgroup differences. Of 94 PwH, 80 PwH (85%) were classified with “unlikely” and 14 (15%) with “at least possible” nociplastic pain (including 5 PwH (5%) with “possible” and 9 PwH (10%) with “probable” nociplastic pain). PwH in both the “unlikely” and “at least possible” nociplastic pain groups showed significantly higher levels of unhelpful psychological factors compared to healthy individuals. Additionally, age may partially account for the observed differences in body height and psychological factors. Larger sample sizes may be needed to detect more subtle between-group differences. study confirmed the presence of nociplastic pain in haemophilia, categorising a notable subgroup as individuals who experience at least possible nociplastic pain. These exploratory insights may provide a starting point for future studies and the development of more effective and tailored pain management. |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T23:00:30Z |
| publishDate | 2023-09-01 |
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| spelling | doaj.art-99385194680d4f7bac0492b637253d9c2023-11-19T09:41:55ZengMDPI AGBiomedicines2227-90592023-09-01119247910.3390/biomedicines11092479The Classification of Suspected Predominant Nociplastic Pain in People with Moderate and Severe Haemophilia: A Secondary Exploratory StudyAnthe Foubert0Nathalie Anne Roussel1Valérie-Anne Chantrain2Philip Maes3Lies Durnez4Sébastien Lobet5Catherine Lambert6Cédric Hermans7Mira Meeus8Research Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy (REVAKI), University of Antwerp, 2000 Antwerp, BelgiumResearch Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy (REVAKI), University of Antwerp, 2000 Antwerp, BelgiumResearch Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy (REVAKI), University of Antwerp, 2000 Antwerp, BelgiumDepartment of Paediatrics, University Hospital Antwerp, 2650 Edegem, BelgiumResearch Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy (REVAKI), University of Antwerp, 2000 Antwerp, BelgiumNeuromusculoskeletal Lab (NMSK), Secteur des Sciences de la Santé, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, 1348 Louvain-la-Neuve, BelgiumHaemostasis and Thrombosis Unit, Division of Hematology, Clinique Universitaires Saint-Luc, 1000 Brussels, BelgiumHaemostasis and Thrombosis Unit, Division of Hematology, Clinique Universitaires Saint-Luc, 1000 Brussels, BelgiumResearch Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy (REVAKI), University of Antwerp, 2000 Antwerp, BelgiumIn people with haemophilia (PwH), joint pain is a major comorbidity that is often overlooked and under-treated. It is believed that, to ensure the most successful outcome, pain management should be tailored to the predominant pain phenotype (i.e., nociceptive, neuropathic and nociplastic). The 2021 clinical criteria and grading system for nociplastic pain, established by the International Association for the Study of Pain (IASP), emphasize the necessity of early-stage identification and predominant pain type classification. Consistent with findings in other chronic musculoskeletal pain conditions, studies suggest that a subgroup of PwH suffers from nociplastic pain, i.e., pain arising from altered nociception rather than structural damage, but this has not yet been explored in PwH. This study aimed to identify PwH with “unlikely”, “possible” and “probable” nociplastic pain and investigate differences in anthropometric, demographic and clinical characteristics and psychological factors between subgroups of PwH and healthy individuals.: The IASP clinical criteria and grading system were used to classify pain types in adult men with moderate or severe haemophilia recruited from two Belgian haemophilia treatment centres. Statistical analyses were applied to study between-subgroup differences. Of 94 PwH, 80 PwH (85%) were classified with “unlikely” and 14 (15%) with “at least possible” nociplastic pain (including 5 PwH (5%) with “possible” and 9 PwH (10%) with “probable” nociplastic pain). PwH in both the “unlikely” and “at least possible” nociplastic pain groups showed significantly higher levels of unhelpful psychological factors compared to healthy individuals. Additionally, age may partially account for the observed differences in body height and psychological factors. Larger sample sizes may be needed to detect more subtle between-group differences. study confirmed the presence of nociplastic pain in haemophilia, categorising a notable subgroup as individuals who experience at least possible nociplastic pain. These exploratory insights may provide a starting point for future studies and the development of more effective and tailored pain management.https://www.mdpi.com/2227-9059/11/9/2479haemophiliapain phenotypingnociplastic painclinical criteriaclassificationgrading system |
| spellingShingle | Anthe Foubert Nathalie Anne Roussel Valérie-Anne Chantrain Philip Maes Lies Durnez Sébastien Lobet Catherine Lambert Cédric Hermans Mira Meeus The Classification of Suspected Predominant Nociplastic Pain in People with Moderate and Severe Haemophilia: A Secondary Exploratory Study Biomedicines haemophilia pain phenotyping nociplastic pain clinical criteria classification grading system |
| title | The Classification of Suspected Predominant Nociplastic Pain in People with Moderate and Severe Haemophilia: A Secondary Exploratory Study |
| title_full | The Classification of Suspected Predominant Nociplastic Pain in People with Moderate and Severe Haemophilia: A Secondary Exploratory Study |
| title_fullStr | The Classification of Suspected Predominant Nociplastic Pain in People with Moderate and Severe Haemophilia: A Secondary Exploratory Study |
| title_full_unstemmed | The Classification of Suspected Predominant Nociplastic Pain in People with Moderate and Severe Haemophilia: A Secondary Exploratory Study |
| title_short | The Classification of Suspected Predominant Nociplastic Pain in People with Moderate and Severe Haemophilia: A Secondary Exploratory Study |
| title_sort | classification of suspected predominant nociplastic pain in people with moderate and severe haemophilia a secondary exploratory study |
| topic | haemophilia pain phenotyping nociplastic pain clinical criteria classification grading system |
| url | https://www.mdpi.com/2227-9059/11/9/2479 |
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