Membrane-mediated dimerization potentiates PIP5K lipid kinase activity

Membrane-mediated dimerization potentiates PIP5K lipid kinase activity

The phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family of lipid-modifying enzymes generate the majority of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] lipids found at the plasma membrane in eukaryotic cells. PI(4,5)P2 lipids serve a critical role in regulating receptor activation, ion ch...

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Bibliographic Details
Main Authors: Scott D Hansen, Albert A Lee, Benjamin R Duewell, Jay T Groves
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
membrane
kinase
phosphatidylinositol phosphate lipids
PIP5K
dimerization
PI(4,5)P2
Online Access:https://elifesciences.org/articles/73747

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