The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey
Over the last four decades, tremendous progress has been made in use of synthetic oligonucleotides as therapeutics. This has been possible largely by introducing chemical modifications to provide drug like properties to oligonucleotides. In this article I have summarized twists and turns on use of c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/5/503 |
| _version_ | 1797535375427633152 |
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| author | Sudhir Agrawal |
| author_facet | Sudhir Agrawal |
| author_sort | Sudhir Agrawal |
| collection | DOAJ |
| description | Over the last four decades, tremendous progress has been made in use of synthetic oligonucleotides as therapeutics. This has been possible largely by introducing chemical modifications to provide drug like properties to oligonucleotides. In this article I have summarized twists and turns on use of chemical modifications and their road to success and highlight areas of future directions. |
| first_indexed | 2024-03-10T11:43:34Z |
| format | Article |
| id | doaj.art-993b2b4ddfce42299811a5e94c5c1bc3 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T11:43:34Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-993b2b4ddfce42299811a5e94c5c1bc32023-11-21T18:17:04ZengMDPI AGBiomedicines2227-90592021-05-019550310.3390/biomedicines9050503The Evolution of Antisense Oligonucleotide Chemistry—A Personal JourneySudhir Agrawal0ARNAY Sciences LLC, Shrewsbury, MA 01545, USAOver the last four decades, tremendous progress has been made in use of synthetic oligonucleotides as therapeutics. This has been possible largely by introducing chemical modifications to provide drug like properties to oligonucleotides. In this article I have summarized twists and turns on use of chemical modifications and their road to success and highlight areas of future directions.https://www.mdpi.com/2227-9059/9/5/503oligonucleotidetherapeuticantisensemedicinal chemistrystructure activity relationship |
| spellingShingle | Sudhir Agrawal The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey Biomedicines oligonucleotide therapeutic antisense medicinal chemistry structure activity relationship |
| title | The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey |
| title_full | The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey |
| title_fullStr | The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey |
| title_full_unstemmed | The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey |
| title_short | The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey |
| title_sort | evolution of antisense oligonucleotide chemistry a personal journey |
| topic | oligonucleotide therapeutic antisense medicinal chemistry structure activity relationship |
| url | https://www.mdpi.com/2227-9059/9/5/503 |
| work_keys_str_mv | AT sudhiragrawal theevolutionofantisenseoligonucleotidechemistryapersonaljourney AT sudhiragrawal evolutionofantisenseoligonucleotidechemistryapersonaljourney |