Evaluation of the Polysaccharide “Immeran” Activity in <i>Syrian hamsters’</i> Model of SARS-CoV-2
COVID-19 is a highly contagious respiratory disease with a high number of lethal cases in humans, which causes the need to search for new therapeutic agents. Polysaccharides could be one of the prospective types of molecules with a large variety of biological activities, especially antiviral. The ai...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-03-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/16/3/423 |
| _version_ | 1827304800227688448 |
|---|---|
| author | Liubov Viktorovna Generalova Denis Pavlovich Laryushkin Irina Anatolievna Leneva Anna Valerievna Ivanina Galina Vladimirovna Trunova Sergei Vladimirovich Dolinnyi Evgenii Aleksandrovich Generalov |
| author_facet | Liubov Viktorovna Generalova Denis Pavlovich Laryushkin Irina Anatolievna Leneva Anna Valerievna Ivanina Galina Vladimirovna Trunova Sergei Vladimirovich Dolinnyi Evgenii Aleksandrovich Generalov |
| author_sort | Liubov Viktorovna Generalova |
| collection | DOAJ |
| description | COVID-19 is a highly contagious respiratory disease with a high number of lethal cases in humans, which causes the need to search for new therapeutic agents. Polysaccharides could be one of the prospective types of molecules with a large variety of biological activities, especially antiviral. The aim of this work was to study the specific antiviral activity of the drug “Immeran” on a model of a new coronavirus infection SARS-CoV-2 in hamsters. Based on the second experiment, intraperitoneal treatment with the drug according to a treatment regimen in doses of 500 and 1000 μg/kg (administration after an hour, then once a day every other day, a total of 3 administrations) was effective, reliably suppressing the replication of the virus in the lungs and, at a dose of 1000 μg/kg, prevented weight loss in animals. In all cases, the treatment stimulated the formation of virus-neutralizing antibodies to the SARS-CoV-2 virus, which suggests that the drug possesses adjuvant properties. |
| first_indexed | 2024-04-24T17:46:22Z |
| format | Article |
| id | doaj.art-993c4abdbf444ed1ac63dacd682f275c |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-24T17:46:22Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-993c4abdbf444ed1ac63dacd682f275c2024-03-27T14:07:50ZengMDPI AGViruses1999-49152024-03-0116342310.3390/v16030423Evaluation of the Polysaccharide “Immeran” Activity in <i>Syrian hamsters’</i> Model of SARS-CoV-2Liubov Viktorovna Generalova0Denis Pavlovich Laryushkin1Irina Anatolievna Leneva2Anna Valerievna Ivanina3Galina Vladimirovna Trunova4Sergei Vladimirovich Dolinnyi5Evgenii Aleksandrovich Generalov6Faculty of Medicine, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, RussiaFederal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”, Institute of Cell Biophysics of the Russian Academy of Sciences, 142290 Pushchino, RussiaMechnikov Research Institute of Vaccines and Sera, Department of Virology, 105064 Moscow, RussiaMechnikov Research Institute of Vaccines and Sera, Department of Virology, 105064 Moscow, RussiaFederal State Budgetary Institution National Medical Research Radiological Center (FSBI NMRRC) of the Ministry of Health of the Russian Federation, P.A. Hertsen Moscow, Oncology Research Institute, 125284 Moscow, RussiaFaculty of Medicine, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, RussiaFaculty of Physics, Lomonosov Moscow State University, 119991 Moscow, RussiaCOVID-19 is a highly contagious respiratory disease with a high number of lethal cases in humans, which causes the need to search for new therapeutic agents. Polysaccharides could be one of the prospective types of molecules with a large variety of biological activities, especially antiviral. The aim of this work was to study the specific antiviral activity of the drug “Immeran” on a model of a new coronavirus infection SARS-CoV-2 in hamsters. Based on the second experiment, intraperitoneal treatment with the drug according to a treatment regimen in doses of 500 and 1000 μg/kg (administration after an hour, then once a day every other day, a total of 3 administrations) was effective, reliably suppressing the replication of the virus in the lungs and, at a dose of 1000 μg/kg, prevented weight loss in animals. In all cases, the treatment stimulated the formation of virus-neutralizing antibodies to the SARS-CoV-2 virus, which suggests that the drug possesses adjuvant properties.https://www.mdpi.com/1999-4915/16/3/423Immeranpolysaccharide<i>Solanum tuberosum</i> L.SARS-CoV-2COVID-19<i>Syrian hamsters</i> |
| spellingShingle | Liubov Viktorovna Generalova Denis Pavlovich Laryushkin Irina Anatolievna Leneva Anna Valerievna Ivanina Galina Vladimirovna Trunova Sergei Vladimirovich Dolinnyi Evgenii Aleksandrovich Generalov Evaluation of the Polysaccharide “Immeran” Activity in <i>Syrian hamsters’</i> Model of SARS-CoV-2 Viruses Immeran polysaccharide <i>Solanum tuberosum</i> L. SARS-CoV-2 COVID-19 <i>Syrian hamsters</i> |
| title | Evaluation of the Polysaccharide “Immeran” Activity in <i>Syrian hamsters’</i> Model of SARS-CoV-2 |
| title_full | Evaluation of the Polysaccharide “Immeran” Activity in <i>Syrian hamsters’</i> Model of SARS-CoV-2 |
| title_fullStr | Evaluation of the Polysaccharide “Immeran” Activity in <i>Syrian hamsters’</i> Model of SARS-CoV-2 |
| title_full_unstemmed | Evaluation of the Polysaccharide “Immeran” Activity in <i>Syrian hamsters’</i> Model of SARS-CoV-2 |
| title_short | Evaluation of the Polysaccharide “Immeran” Activity in <i>Syrian hamsters’</i> Model of SARS-CoV-2 |
| title_sort | evaluation of the polysaccharide immeran activity in i syrian hamsters i model of sars cov 2 |
| topic | Immeran polysaccharide <i>Solanum tuberosum</i> L. SARS-CoV-2 COVID-19 <i>Syrian hamsters</i> |
| url | https://www.mdpi.com/1999-4915/16/3/423 |
| work_keys_str_mv | AT liubovviktorovnageneralova evaluationofthepolysaccharideimmeranactivityinisyrianhamstersimodelofsarscov2 AT denispavlovichlaryushkin evaluationofthepolysaccharideimmeranactivityinisyrianhamstersimodelofsarscov2 AT irinaanatolievnaleneva evaluationofthepolysaccharideimmeranactivityinisyrianhamstersimodelofsarscov2 AT annavalerievnaivanina evaluationofthepolysaccharideimmeranactivityinisyrianhamstersimodelofsarscov2 AT galinavladimirovnatrunova evaluationofthepolysaccharideimmeranactivityinisyrianhamstersimodelofsarscov2 AT sergeivladimirovichdolinnyi evaluationofthepolysaccharideimmeranactivityinisyrianhamstersimodelofsarscov2 AT evgeniialeksandrovichgeneralov evaluationofthepolysaccharideimmeranactivityinisyrianhamstersimodelofsarscov2 |