Design and Evaluation of S-Protected Thiolated-Based Itopride Hydrochloride Polymeric Nanocrystals for Functional Dyspepsia: QbD-Driven Optimization, In Situ, In Vitro, and In Vivo Investigation

Design and Evaluation of S-Protected Thiolated-Based Itopride Hydrochloride Polymeric Nanocrystals for Functional Dyspepsia: QbD-Driven Optimization, In Situ, In Vitro, and In Vivo Investigation

Mucoadhesive nanosized crystalline aggregates (NCs) can be delivered by the gastrointestinal, nasal, or pulmonary route to improve retention at particular sites. Itopride hydrochloride (ITH) was selected as a drug candidate due to its absorption from the upper gastrointestinal tract. For drug locali...

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Bibliographic Details
Main Authors: Moutaz Y. Badr, Pratap Basim, Khaled M. Hosny, Waleed Y. Rizg, N. Raghavendra Naveen, Mallesh Kurakula, Fayez Alsulaimani, Awaji Y. Safhi, Fahad Y. Sabei, Mohammed Alissa, Abdulmohsin J. Alamoudi
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Pharmaceuticals
Subjects:
optimization
sustainability of natural resources
nanosized
crystalline aggregates
mucoadhesive
thiolated
Online Access:https://www.mdpi.com/1424-8247/16/7/925

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