IGF-IR targeted therapy: past, present and future

IGF-IR targeted therapy: past, present and future

The IGF-I Receptor (IGF-IR) has been studied as an anti-cancer target. However, monotherapy trials with IGF-IR targeted antibodies or with IGF-IR specific tyrosine kinase inhibitors has, overall, been very disappointing in the clinical setting. This review discusses potential reasons why IGF-I R...

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Bibliographic Details
Main Authors:	Joseph A.M.J.L. Janssen, Aimee J Varewijck
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2014-12-01
Series:	Frontiers in Endocrinology
Subjects:	Hyperglycemia Cancer IGF-I receptor Insulin receptor-A Insulin Receptor-B IGF-IR targeted therapy
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00224/full

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